The impact of environmental and human factors on urban heat and microclimate variability

Urbanization is known to cause noticeable changes in the properties of local climate. Studies have shown that urban areas, compared to rural areas with less artificial surfaces, register higher local temperatures as a result of Urban Heat Islands (UHIs). Hong Kong is one of the most densely populated cities in the world and a high proportion of its population residing in densely built high-rise buildings are experiencing some degrees of thermal discomfort. This study selected Mong Kok and Causeway Bay, two typical urban communities in Hong Kong, to gather evidence of microclimate variation and sources of thermal discomfort. UHIs were estimated from 58 logging sensors placed at strategic locations to take temperature and humidity measurements over 17 consecutive days each in the summer/hot and winter/cool periods. By employing geographic information and global positioning systems, these measurements were geocoded and plotted over the built landscape to convey microclimate variation. The empirical data were further aligned with distinct environmental settings to associate possible factors contributing to UHIs. This study established the existence and extent of microclimate variation of UHI within urban communities of different environmental configuration and functional uses. The findings provided essential groundwork for further studies of UHI effects to inform sources of local thermal discomfort and better planning design to safeguard environmental health in public areas.postprin

Evidence-based psychosocial service for people with chronic illness & their families: outcomes on mental health & wellness

published_or_final_versionThe HKEC Symposium on Community Engagement V: Family - The Key to a Healthy Community, Hong Kong, 15 May 2010

Integrative Eastern Body-mind-spirit healing - arts and science of acceptance and transformation of pain and suffering

Special PresentationDisease, frailty, disability and dying are painful, stressful, uncomfortable, and agitating. Despite old age and death are inevitable processes in living, people do hope that one can stay young, energetic, cheerful and happy all the time besides enjoying longevity. Western positivistic treatment focuses on an antagonistic stance of fighting the disease and treats illness as an enemy. Eastern integrative healing philosophy emphasizes on holistic harmonization of bodily strengths and energies. Ill health is seen as system imbalance which can be restored. Endurance of pain and suffering are seen as virtues in life. A reflective mechanism of acceptance can help foster a process of transformation from pain and suffering into enlightenment and peace of mind. This presentation will share arts and science of an integrative eastern body-mind-spirit healing in Hong Kong.published_or_final_versio

Spatial analytical methods for deriving a historical map of physiological equivalent temperature of Hong Kong

Physiological Equivalent Temperature (PET) has been widely used as an indicator for impacts of climate change on thermal comfort of humans. The effects of thermal stress are often examined using longitudinal observational studies over many years. A major problem in retrospective versus prospective studies is that it is not feasible to go back in time to measure historical data not collected in the past. These data must be reconstructed for the baseline period to enable comparative analysis of change and its human impact. This paper describes a systematic method for constructing a PET map using spatial analytical procedures. The procedures involve estimating PET values (based on the RayMan model and four key parameters of temperature, relative humidity, wind velocity, and mean radiant temperature) at a spatially disaggregated level comprising of a grid of 100 m × 100 m cells. The method can be applied to other geographic locations pending availability of basic meteorological and morphological data of the locations.postprin

Predictors of treatment outcome in patients treated with radical chemoradiotherapy for stage III Non-small Cell Lung Cancer

Proffered SessionBACKGROUND: Chemoradiation has been well established as standard treatment for stage III non-small cell lung cancer (NSCLC). Previous studies have shown that the tumour size as well as its metabolic activity predict treatment outcome after definitive treatment for early-stage disease. We would like to investigate if there are any clinical and metabolic predictors of treatment outcome for stage III NSCLC after chemoradiation. PATIENTS AND METHODS: 56 consecutive patients (46 males and 10 females) treated with radical concurrent chemoradiation for their stage IIIA (n=21) and IIIB (n=35) (AJCC 7th edition) unresectable non-small cell lung cancer between July 2006 to February 2012 were retrospectively reviewed. 42 patients had positron emission tomography with integrated computed tomography (PET-CT) scan performed at diagnosis. Of which 14 patients also had PET-CT scan after induction chemotherapy and before concurrent chemoradiation. All received concurrent chemoradiation +/- induction ...postprin

Comparison of post-treatment plasma EBV DNA with nasopharyngeal biopsy in patients after radical (chemo) radiotherapy for non-metatatic nasopharyngeal cancer

This journal suppl. entitled: Proceedings of the American Society for Radiation Oncology 56th Annual Meeting, ASTRO's 56th Annual Meeting ... 2014Oral Scientific SessionPURPOSE/OBJECTIVE(S): Random nasopharyngeal biopsy after completion of intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal cancer (NPC) is routinely practiced in Hong Kong to confirm local remission. Plasma EBV DNA is proven an accurate marker for NPC. We carried out a prospective study comparing the correlation between post-IMRT nasopharyngeal biopsy and EBV DNA, to investigate if EBV DNA can substitute biopsy to confirm local remission. MATERIALS/METHODS: Patients with non-metastatic NPC treated with definitive (chemo) IMRT diagnosed between January 2011 and March 2013 were recruited. After baseline workup ...postprin

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Microclimate variations of urban Heat Island effects within urban areas of Hong Kong

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