Translation and validation of the Chinese (HK) version of GOHAI

published_or_final_versio

Functional occluding units and satisfaction with dental condition in elderly

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Development of an oral health expectation index for elderly

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Patterns, aetiology and risk factors of intimate partner violence-related injuries to head, neck and face in Chinese women

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A comparison of intimate partner violence and associated physical injuries between cohabitating and married women: a 5-year medical chart review

published_or_final_versio

Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide

Temozolomide (TMZ) is standard chemotherapy for glioblastoma multiforme (GBM). Intratumoral hypoxia is common in GBM and may be associated with the development of TMZ resistance. Oxygen therapy has previously been reported to potentiate the effect of chemotherapy in cancer. In this study, we investigated whether hyperoxia can enhance the TMZ-induced cytotoxicity of human GBM cells, and whether and how it would resensitize TMZ-resistant GBM cells to TMZ. TMZ-sensitive human GBM cells (D54-S and U87-S) were treated with TMZ to develop isogenic subclones of TMZ-resistant cells (D54-R and U87-R). All cell lines were then exposed to different oxygen levels (1, 21, 40, or 80 %), with or without concomitant TMZ treatment, before assessment of cell cytotoxicity and morphology. Cell death and survival pathways elicited by TMZ and/or hyperoxia were elucidated by western blotting. Our results showed that TMZ sensitivity of both chemo-sensitive and resistant cells was enhanced significantly under hyperoxia. At the cell line-specific optimum oxygen concentration (D54-R, 80 %; U87-R, 40 %), resistant cells had the same response to TMZ as the parent chemosensitive cells under normoxia via the caspase-dependent pathway. Both TMZ and hyperoxia were associated with increased phosphorylation of ERK p44/42 MAPK (Erk1/2), but to a lesser extent in D54-R cells, suggesting that Erk1/2 activity may be involved in regulation of hyperoxia and TMZ-mediated cell death. Overall, hyperoxia enhanced TMZ toxicity in GBM cells by induction of apoptosis, possibly via MAPK-related pathways. Induced hyperoxia is a potentially promising approach for treatment of TMZ-resistant GBM.published_or_final_versio

Territory-wide ventriculoperitoneal shunting outcomes from 2009 to 2011: Multicenter Hospital Authority Clinical Audit

Free paper 7Meeting Theme: Degenerative Lumbar SpineVentriculoperitoneal (VP) shunting for the management of hydrocephalus is one of the most common procedures performed in daily neurosurgical practice. Although surgical techniques and perioperative management have reduced the incidence of shunt failure, the procedure is still fraught with potential complications. Approaching a third of adult patients (29%) experience shunt failure within the first year and as high as 59% of patients regardless of age require shunt revision during their lifetime1. The aim of this study is to determine the rate of shunt failure in Hong Kong’s public health system and identify its causes as well as risk factors …published_or_final_versio

Promotion of collaboration between medical and dental professionals

Includes bibliographical references (p. 25-26).published_or_final_versio

Oral Health Impact on Daily Living (OHIDL) Questionnaire: Longitudinal validity

Poster PresentationSession 22: P2Conference Theme: We are the FutureObjective: OHIDL was developed to measure the perceived oral health impacts on daily life. The transition scale in OHIDL was used to measure the change in perceived impacts after dental treatment. This study aimed to examine its longitudinal validity. Method: Elderly subjects aged 55 years or above were recruited from four dental clinics in Hong Kong. They were asked to rate the intensity level of 16 items in OHIDL before and after dental treatment. They were also asked to retrospectively rate the transition (change of the intensity) of these items after the treatment. Intensity and transition scores were calculated through summing up the responses. Change score was calculated as the difference between the two intensity scores before and after treatment. The associations of the transition and change scores with the global rating of change were used to evaluate their responsiveness. Result: A total of 176 subjects (mean age: 60.1 years; SD: 8.1) completed the follow-up interviews after treatment. Subjects who reported no global change in oral health impacts had an insignificant mean transition score from zero (mean=0.44, 95% CI: -0.03 -0.92) but a significant positive change score (mean=2.1, 95% CI=0.97-3.22). Subjects who reported improvement and deterioration had significant positive and negative mean transition scores respectively. The correlation between the transition score and the global rating of change (rs=0.76, p<0.05) was higher than that between the change score and the global rating (rs=0.37, p<0.05). Conclusion: Using transition scale in OHIDL to measure change in perceived oral health impacts after dental treatments in the elderly in Hong Kong is valid and more responsive to detect change than the change score

Prolyl 4-hydroxylase, beta polypeptide (P4HB) as a potential target for combating temozolomide resistance in human malignant glioma

Parallel Session: Free Paper Session IIB - Oral Presentation (General & Epilepsy