An update on irreversible electroporation of liver tumours

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Predictive factors for neurological deterioration after surgical decompression for thoracic ossified yellow ligament

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Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of polygonum multiflorum thunb and Panax ginseng CA Meyer

Author name used in this publication: Jian-Hong WuAuthor name used in this publication: Alice Lai-Shan AuAuthor name used in this publication: Peter Hoi-Fu Yu2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Adhesion aspect of incorporating zirconate coupling agent in resin composites

Oral Session - 16 Dental Materials IV - Composites: no. 202OBJECTIVE: In general, silane-based resin composites cannot achieve an efficient and satisfactory direct resin-zirconia bonding. Due to the chemical nature of zirconate that has the direct bonding ability with zirconia, thus zirconate was used in this study instead of silane as coupling agent and incorporated in experimental resin composite. It was hypothesized that zirconate could give a better mechanical performance in direct resin-zirconia bonding. METHOD: Various ratios (0.0 – 4.0wt.%) of zirconate coupling agent (NZ-33, Kendrich Petrochemical, USA) were incorporated in an experimental bis-GMA/MMA-based resin composites. Compressive strength of the experimental resin composite and shear bond strength (SBS) of resin-to-zirconia were evaluated by using universal testing mach...link_to_OA_fulltex

The interplay between epigenetic regulation and CD8+ T cell differentiation/exhaustion for T cell immunotherapy

202212 bckwVersion of RecordPublishe

Patient-clinician communication and needs identification for outpatients with schizophrenia in Hong Kong: Role of the 2-COM instrument

Objectives: To assess perceived needs of schizophrenic outpatients in Hong Kong, and the effectiveness of clinicians in identifying those needs; and to explore the use of a self-rated instrument to enhance needs identification. Participants and Methods: The two-way communication checklist was completed by 70 outpatients before consultation. Their clinicians were either given the checklist during the consultation (2-COM group, n = 36), or were unaware of the patients' answers and independently completed the checklist (needs awareness group, n = 34). A standard care group (n = 35) was included for comparison. Consultation time and patient satisfaction were also recorded. Results: The major concern of patients was information about their illness and treatment (59%). In the needs awareness group, under-recognition of patients' needs by clinicians was observed in various domains. Consultation time (mean, 5.6 minutes) correlated with the number of needs identified by clinicians. The 2-COM group showed a trend towards higher satisfaction compared to the standard care group, although this did not reach statistical significance. Conclusions: Clinicians may under-identify problems perceived by patients due to time constraints and other factors. The use of a structured questionnaire may facilitate effective needs identification in a busy outpatient clinic. © 2008 Hong Kong College of Psychiatrists.link_to_subscribed_fulltex

Recent advances in two-dimensional transition metal dichalcogenide nanocomposites biosensors for virus detection before and during COVID-19 outbreak

202202 bcvcVersion of RecordOthersThis research is funded by the Department of Biomedical Engineering of the Hong Kong Polytechnic University and and grant number A0033912 and 0035876.Publishe

The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation

Given the reported side effects associated with chemotherapy and surgical resection, dietary intervention with ω-3 polyunsaturated fatty acids (PUFAs) has been postulated to be an alterative way to prevent liver cancer progression and metastasis. We studied the effects of an ω-3 PUFA, docahexaenoic acid (DHA) on COX-2 expression and the cell cycle control machinery that co-ordinately regulate the HCC cells growth. Our data showed that DHA (0-200 μM) retarded proliferation of the human metastatic HCC cell line MHCC97L dose-dependently. In addition, inhibition of cyclin A/Cdk2 interfered with S-phase progression further in agreement with the result of bivariate flow cytometric analysis which indicated that DNA synthesis time (T s) was significantly prolonged by DHA in MHCC97L. The N-myc oncogene, the heat shock proteins Hsp27 and glucose-related protein 78 (GRP78) as well as the antioxidant enzymes superoxide dismutase may play significant roles in the cell cycle control and reduced-proliferation of MHCC97L by DHA. Our data indicated that it is imperative to develop therapeutic strategy with ω-3 PUFA that simultaneously targets COX-2 and other cell cycle regulators in hepatocarcinogenesis. This study provides novel mechanistic insights into the modulation of DHA on human hepatocarcinoma.link_to_OA_fulltex

Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity

Carbon tetrachloride (CCl4) is a common hepatotoxin used in experimental models to elicit liver injury. To identify the proteins involved in CCl4-induced hepatotoxicity, two-dimensional gel electrophoresis was employed followed by mass spectrometry - mass spectrometry (MS/MS) to study the differentially expressed proteins during CCl4 exposure in the Fischer 344 rat liver proteome for 5 weeks. Ten spots with notable changes between the Control and CCl4 groups were successfully identified. Among them, four proteins with significant up-regulation, namely calcium-binding protein 1, protein disulfide isomerase, mitochondrial aldehyde dehydrogenase precursor, and, glutathione-S-transferase mu1 and six proteins with significant down-regulation, namely catechol-O-methyltransferase, hemoglobin-alpha-2-chain, hemopexin precursor, methionine sulfoxide reductase A, catalase and carbonic anhydrase 3, were identified. The data indicates that CCl4 causes hepatotoxicity by depleting oxygen radical scavengers in the hepatocytes. In this rat model, we profiled hepatic proteome alterations in response to CCl4 intoxication. The findings should facilitate understanding of the mechanism of CCl4-induced liver injury. © 2011 SAGE Publications.link_to_subscribed_fulltex