The Marketing Plan of the Cotai Strip

In 2003, when most the current Cotai Strip was still a piece of reclaimed land, Sheldon Adelson started a visionary development on this piece of land: the Asian Las Vegas - the Cotai Strip under the corporate Sands China Limited. Its first property, the Venetian Macau was opened in August 2007 followed with a Four Seasons hotel in 2008 with a great success. The forthcoming project is the Sands Cotai Central which includes a 1,200-rooms Holiday Inn Macau, a 600-rooms Conrad Macau and a 4,000-rooms Sheraton Macao with an additional complex of casino, meeting facilities, and shopping mall. Marketing these different hotels and the Venetian Macao separately is not only costly but is also possibly conflicting to each other. Together with the existing resources Sands China owns (the Cotai Jet – ferry service between HK & Macau, the largest fleet of tour bus and the existing strong brand image of the Venetian Macau), it will be much cost effective and efficient to market a new tourist destination – the entire Cotai Strip, that consists of different hotels and other element of entertainment where customers have a great variety of choice to stay and experience

Enhancing Elderly Advance Care Planning Experience at a Primary Care Clinic

The purpose of the project was to examine if the identification of readiness for an advance care planning (ACP) discussion of elderly participants would enhance the outcomes of participants\u27 satisfaction, improve the likelihood of having an ACP discussion and increase the completion rates of an advance directive (AD) document after an office visit. Forty-four elderly participants, who met the selection criteria, were recruited from a primary clinic in Northern California from October 1, 2017 to December 31, 2017 (Female, n =28). All participants were randomly assigned to either an intervention group (n= 22) or a control group (n =22). Their age ranged from 65 to 89 years (M = 72.89; SD = 7 .31). A pre- and a post-visit self-administrated questionnaire were used for data collection with a follow-up phone call made to the participants post-visit. Project findings indicated that the intervention participants who were ready for an ACP discussion were more likely to have an ACP discussion and complete an AD document than the control participants post-visit (p \u3c.05). Although there were significant differences of some demographic variables between groups to confound the ACP outcomes, findings of this project were clinically significant. In conclusion, the investigator advised that primary care providers should initiate the ACP discussion, document the conversation and complete an AD document when the elderly patients clearly state that they are ready for an ACP discussion

Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: Apoptosis is a major target and treatment effect of multiple chemotherapeutical agents in cancer. A soybean isoflavone, genistein, is a well-studied chemopreventive agent and has been reported to potentiate the anticancer effect of some chemotherapeutics. However, its mechanistic basis of chemo-enhancement effect remains to be fully elucidated. METHODS: Apoptotic features of low concentration stressed cancer cells were studied by microscopic method, western blot, immunostaining and annexin V/PI assay. Genistein's effects on unstressed cells and recovering cells were investigated using MTT cell viability assay and LDH cytotoxicity assay. Quantitative real-time PCR was employed to analyze the possible gene targets involved in the recovery and genistein's effect. RESULTS: Low-concentration ethanol stressed cancer cells showed apoptotic features and could recover after stress removal. In stressed cells, genistein at sub-toxic dosage promoted the cell death. Quantitative real-time PCR revealed the up-regulation of anti-apoptotic genes MDM2 and XIAP during the recovery process in HeLa cells, and genistein treatment suppressed their expression. The application of genistein, MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells caused persistent caspase activity and enhanced cell death. Flow cytometry study indicated that genistein treatment could lead to persistent phosphatidylserine (PS) externalization and necrotic events in the recovering HeLa cells. Caspase activity inhibition shifted the major effect of genistein to necrosis. CONCLUSIONS: These results suggested two possible mechanisms through which genistein promoted cell death in stressed cancer cells. Genistein could maintain the existing apoptotic signal to enhance apoptotic cell death. It could also disrupt the recovering process in caspase-independent manner, which lead to necrotic events. These effects may be related to the enhanced antitumor effect of chemotherapeutic drugs when they were combined with genistein

A Probabilistic Linear Genetic Programming with Stochastic Context-Free Grammar for solving Symbolic Regression problems

Traditional Linear Genetic Programming (LGP) algorithms are based only on the selection mechanism to guide the search. Genetic operators combine or mutate random portions of the individuals, without knowing if the result will lead to a fitter individual. Probabilistic Model Building Genetic Programming (PMB-GP) methods were proposed to overcome this issue through a probability model that captures the structure of the fit individuals and use it to sample new individuals. This work proposes the use of LGP with a Stochastic Context-Free Grammar (SCFG), that has a probability distribution that is updated according to selected individuals. We proposed a method for adapting the grammar into the linear representation of LGP. Tests performed with the proposed probabilistic method, and with two hybrid approaches, on several symbolic regression benchmark problems show that the results are statistically better than the obtained by the traditional LGP.Comment: Genetic and Evolutionary Computation Conference (GECCO) 2017, Berlin, German

Is gender equality a prerequisite for economic advancement?

published_or_final_versionInternational and Public AffairsMasterMaster of International and Public Affair

Cohort profile: The prospective study on Chinese elderly with multimorbidity in primary care in Hong Kong

Acknowledgments We would like to thank the General Outpatient Clinics (Lek Yuen, Ma On Shan, Shatin (Tai Wai), Yuen Chau Kok) and Shatin Rhenish Neighbourhood Elderly Centre for the support and help in recruitment. We also greatly thank all the patients who joined in the cohort. Funding The staff working on this cohort received funding from the Hong Kong Jockey Club Charities Trust. Competing interests None declared. Patient consent for publication Not required. Provenance and peer review Not commissioned; externally peer reviewed. Data availability statement Data are available on reasonable request. The authors warmly welcome collaborations for future research based on this study. For those who would like to request for the data or propose new assessments into the follow-up assessments, they can email to: ([email protected]). For more information please see the website: http://cpcp.sphpc.cuhk.edu.hk/chi/.Peer reviewedPublisher PD

Assessing the spatial distribution of methadone clinic clients and their access to treatment

Using Geographic Information System (GIS), the spatial distribution of methadone clinic clients and their utilization of a treatment service in Hong Kong was analysed. A majority (93.7%) of the 63 methadone users recruited were residing in the same district, of which 84.1% spent not more than 15 minutes for traveling. Walking (55.6%) was the commonest transport mode followed by cycling (30.2%). There was no distance decay effect on traveling time, but an association between distance and transport selection could be demonstrated. The residence locations displayed a compact distribution, merging with the general population without any evidence of clustering. Though the distribution of methadone users could have been shaped by the location of clinic, it can also be concluded that methadone clinics at convenient locations are needed if maintenance is a key determinant of service effectiveness

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study

Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio