191 research outputs found
Conflicting Risk Attitudes
AbstractThis paper examines whether differences in individual risk attitudes are related to interpersonal conflict. In more than thirty villages of rural Uganda, we conduct a social survey to document social links between pairs of individuals within a village, and separately elicit individual risk attitudes using an incentivized task. Our findings reveal that the difference in risk attitudes between two individuals is significantly and positively related to the presence of interpersonal conflict between them. This relationship is particularly strong among kin. By contrast, the strength of risk aversion per se is not related to conflict. Further, we conduct simulations that suggest that the relationship cannot be solely explained by diverging attitudes after the severing of social ties as a result of interpersonal conflict
Plantar fasciopathy: revisiting the risk factors
Background Plantar fasciopathy is the most common cause of acquired sub-calcaneal heel pain in adults. To-date, research of this condition has mainly focused on management rather than causal mechanisms. The aetiology of plantar fasciopathy is likely to be multifactorial, as both intrinsic and extrinsic risk factors have been reported. The purpose of this review is to critically reevaluate risk factors for plantar fasciopathy. Methods A detailed literature review was undertaken using English language medical databases. Results No clear consensus exists as to the relative strength of the risk factors reported. Conclusions To-date numerous studies have examined various intrinsic and extrinsic risk factors implicated in the aetiology of plantar fasciopathy. How these factors interact may provide useful data to establish an individualsâ risk profile for plantar fasciopathy and their potential for response to treatment. Further research is indicated to rank the relative significance of these risk factors
Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.Fil: Ruiz, Paul. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra. Universidad Nacional de CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra; Argentina. Universidad de la RepĂșblica; UruguayFil: Calliari, Aldo. Universidad de la RepĂșblica; UruguayFil: Genovese, Patricia. Universidad de la RepĂșblica; UruguayFil: Scorza, Cecilia. Instituto de Investigaciones BiolĂłgicas "Clemente Estable"; UruguayFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra. Universidad Nacional de CĂłrdoba. Instituto de InvestigaciĂłn MĂ©dica Mercedes y MartĂn Ferreyra; Argentina. Universidad Nacional de CĂłrdoba. Facultad de PsicologĂa; Argentin
Neural Models of Normal and Abnormal Behavior: What Do Schizophrenia, Parkinsonism, Attention Deficit Disorder, and Depression Have in Common?
Defense Advanced Research Projects Agency and Office of Naval Research (N00014-95-1-0409); National Science Foundation (IRI-97-20333
The real risks of steroid injection for plantar fasciitis, with a review of conservative therapies
This article presents a review of conservative therapies for plantar fasciitis pain reduction with a discussion of steroid therapy risks. The therapies reviewed include orthoses, stretching, extracorporeal shockwave, BTX-A, and corticosteroid injection/iontophoresis. These modes were included based on the availability of double blinded randomized controlled trials. We noted the following findings. Orthoses, regardless of type, can improve pain levels. Plantar stretching shows limited short-term benefit (1Â month), but can reflect significant long-term improvement (10Â months). Extracorporeal shockwave therapy shows equivocal benefit with some studies showing significant improvement and others showing none. Although BTX-A injections were the least studied, significant pain improvement was demonstrated in the short and long term. Steroid injection/iontophoresis showed significant improvement in the short term (1Â month). Steroid therapy, when coupled with plantar stretching, can provide efficacious pain relief; however, steroid injections should be combined with ultrasound monitoring to reduce complications
Gene expression of human beta-defensins in healthy and inflamed human dental pulps
Problemstellung: Humane beta-Defensine (hBDs) sind antimikrobielle Peptide,
die in der Formierung der angeborenen, lokalen Immunantwort eine wichtige
Rolle zu spielen scheinen. Die Bedeutung dieser Peptide in der menschlichen
Zahnpulpa ist noch nicht ausreichend geklÀrt. Zielsetzung: Das Ziel der Studie
war, die Genexpression der humanen beta-Defensine-1, -2, -3 und -4 sowie
TNF-α, COX-2, IL-1ÎČ und -6 im gesunden und entzĂŒndeten Pulpagewebe zu
untersuchen. Die Expression von proinflammatorischen Zytokinen diente in der
vorliegenden Arbeit als Kontrolle der tatsĂ€chlich vorhandenen EntzĂŒndung.
Material und Methoden: Die gesunden und entzĂŒndeten Pulpen wurden entweder
durch Vitalexstirpation oder post extractionem entnommen. Die Proben wurden
unter Zugabe von RNA-Stabilisationsreagens sofort nach der Entnahme bis zur
weiteren Verarbeitung in flĂŒssigem Stickstoff schockgefroren und bei -80 °C
gelagert. Die mRNA wurde nach dem Homogenisieren der Proben mittels TRIzol-
Methode extrahiert und anschlieĂend in einer Reverse-Transkriptase-Reaktion in
cDNA umgeschrieben. Die quantitative Analyse der Genexpression erfolgte
mittels Real-Time-Polymerasekettenreaktion. Die Auswertung der Ergebnisse
wurde mittels Mann-Whitney-U-Tests durchgefĂŒhrt. Ergebnisse: Die Genexpression
von humanen beta-Defensinen und proinflammatorischen Zytokinen findet im
Pulpagewebe statt. HBD-2 und hBD-3 wurden sowohl in gesunden als auch in
entzĂŒndeten Pulpen nur schwach exprimiert. FĂŒr hBD-1 und hBD-4 konnten in
entzĂŒndeten Pulpen im Vergleich zu gesunden Proben signifikant erhöhte
Genexpressionen nachgewiesen werden. Die Genexpression fĂŒr die
proinflammatorischen Zytokine TNF-α, COX-2 und IL-1ÎČ war gegenĂŒber den
gesunden bei den entzĂŒndeten Pulpen erhöht. FĂŒr das proinflammatorische
Zytokin IL-6 konnten keine signifikante Unterschiede bezĂŒglich der
Genexpression gefunden werden. Schlussfolgerung: Humane beta-Defensine-1 und
-4 sowie die proinflammatorischen Zytokine TNF-α, COX-2 und IL-1ÎČ werden in
entzĂŒndeten Pulpen verstĂ€rkt exprimiert. Die Expression dieser Peptide spielt
eine Rolle bei der entzĂŒndlichen Reaktion der menschlichen Pulpa.Statement of problem: Human beta-defensins (hBDs) are antimicrobial peptides
that play an important role in the innate host defense against bacterial
invasion, contribute to promotion of adaptive immune responses and show
chemotactic activities. Until now, the role of hBDs in the human dental pulp
has not been adequately investigated. Objectives: The aim of this study was to
determine the expression of hBD-1, -2, -3, -4 and proinflammatory cytokines
TNF-α, COX-2, IL-1ÎČ and -6 in healthy and inflamed human dental pulps. In the
present study cytokines were used as molecular diagnostic markers for pulpal
inflammation. Materials and methods: Samples of healthy and inflamed dental
pulps were obtained from extracted third molars and during treatment of
pulpitic teeth. Pulp tissue specimens were immediately frozen in liquid
nitrogen with addition of RNA stabilization reagent and stored at -80 °C.
Total RNA was extracted from homogenized pulp tissue using the TRIzol method
Gene expression was assessed using Reverse Transcriptase Reaction and Real-
Time-PCR. Differences in gene expression between healthy and inflamed pulps
were compared using Mann-Whitney-U test. Results: The expression of human
beta-defensins and cytokins was observed in human dental pulps. HBD-2 and -3
were only weakly expressed in healthy and inflamed pulps. In contrast, the
expression of hBD-1 and -4 was significantly increased in inflamed compared to
healthy pulps. The expression of TNF-α, COX-2, IL-1ÎČ (but not IL-6) was also
significantly increased during inflammation. Conclusions: These results
suggest that beta-defensins obviously play a role in the innate pulpal host
defence
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Beyond National Origins: The Development of Modern Immigration Policymaking, 1948-1968
This dissertation examines the development of the modern system of immigration policy. In doing so I shift the lens of analysis from singular strands of legislation to the most enduring facet of postwar reform: the three major categories of permanent immigrant admissions - family reunion, labor-market, and refugee - enshrined in the Hart-Celler Act of 1965. Hart-Celler ended the race-based national origins quota system which had governed immigrant admissions since the 1920s, and implemented a new preference system that allotted just under three quarters of all visas to family reunification, with the remainder for labor migrants and refugees. I ask why policymakers created a system so heavily weighted toward family reunification and how they decided who qualified for each admissions preference. The idea of using these specific categories, and of allotting the lion's share of visas to family, marked a revolutionary break from the past. Far from being primordial or pre-ordained, the shape of the preferences emerged from two decades of political struggle.Examining the development of these categories of admission within one overarching admissions structure allows me to detail the long history of policy development. Using a range of archival sources, including the under-utilized State Department records, I follow political and legal processes as they emerged and intertwined from multiple venues, including the executive branch, federal bureaucracies, congress, and civil society groups. My research shows that more than any other factor - more than the will of powerful individuals; of the sausage-making legislative process; or the shape of political coalitions and public opinion - what mattered most for the development of the preference categories, and thus for immigration policymaking itself, was a series of successful short-sighted defenses of older policies and unsuccessful reform efforts. These early attempts at defense and reform in the late-1940s to early-1960s did not answer the key question of immigration policy in the postwar era: how to regulate admissions without the use of the race-based quotas. But, over the course of two decades, they set in motion a positive feedback cycle that, once full-scale legislative reform was possible with the Hart-Celler Act, pushed policymakers to implement a heavily family-reunification based system. Critically, this feedback loop functioned largely below the radar, constraining policymaking in a manner overlooked even by those officials most intimately connected with immigration reform. While other pieces of legislation, such as the Immigration Reform and Control Act of 1986 and the Immigration Act of 1990, have made cosmetic changes to the admissions regime, for example raising the numbers of people admissible each year, the foundations of the system - the three categories and emphasis on family reunification - remain the same. These three preferences, above any other facet of policymaking, have shaped the modern immigration regime, with all of its trials and tribulations, including long backlogs in the family preference categories, large numbers of undocumented immigrants, and a disconnect between labor-market needs and available visas. Though many of the constrictions on policymaking from the postwar era emerged from the peculiar history of the national origins quotas, I conclude that the lessons about policy defense and failed reform are applicable to contemporary immigration policymaking
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