Do hep neutrinos affect the solar neutrino energy spectrum?

If the low energy cross section for 3He + p goes to 4He + e + nu_e, the `hep' reaction, is > 20 times larger than the best (but uncertain) theoretical estimates, then this reaction could significantly influence the electron energy spectrum produced by solar neutrino interactions and measured in the SuperKamiokande, SNO, and ICARUS experiments. We compare predicted energy spectra for different assumed hep fluxes and different neutrino oscillation scenarios with the observed SuperKamiokande spectrum. The spectra with enhanced hep contributions provide better fits to the SuperKamiokande data.Comment: Accepted Phyics Letters B. Related information at http://www.sns.ias.edu/~jnb . LaTeX file. 12 pages including 2 figures. Typo in Table 2 correcte

The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction

Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the body. One possible therapeutic application involves the use of these cells to treat myocardial infarction (MI), a condition where billions of cardiomyocytes (CMs) are lost. Although several protocols have been developed to differentiate PSCs towards CMs, none of these provide a completely pure population, thereby still posing a risk for neoplastic teratoma formation. Therefore, we developed a strategy to (i) monitor cell behavior noninvasively via site-specific integration of firefly luciferase (Fluc) and the human positron emission tomography (PET) imaging reporter genes, sodium iodide symporter (hNIS) and somatostatin receptor type 2 (hSSTr2), and (ii) perform hSSTr2-mediated suicide gene therapy via the clinically used radiopharmacon 177Lu-DOTATATE. Methods: Human embryonic stem cells (ESCs) were gene-edited via zinc finger nucleases to express Fluc and either hNIS or hSSTr2 in the safe harbor locus, adeno-associated virus integration site 1. Firstly, these cells were exposed to 4.8 MBq 177Lu-DOTATATE in vitro and cell survival was monitored via bioluminescence imaging (BLI). Afterwards, hNIS+ and hSSTr2+ ESCs were transplanted subcutaneously and teratomas were allowed to form. At day 59, baseline 124I and 68Ga-DOTATATE PET and BLI scans were performed. The day after, animals received either saline or 55 MBq 177Lu-DOTATATE. Weekly BLI scans were performed, accompanied by 124I and 68Ga-DOTATATE PET scans at days 87 and 88, respectively. Finally, hSSTr2+ ESCs were differentiated towards CMs and transplanted intramyocardially in the border zone of an infarct that was induced by left anterior descending coronary artery ligation. After transplantation, the animals were monitored via BLI and PET, while global cardiac function was evaluated using cardiac magnetic resonance imaging. Results: Teratoma growth of both hNIS+ and hSSTr2+ ESCs could be followed noninvasively over time by both PET and BLI. After 177Lu-DOTATATE administration, successful cell killing of the hSSTr2+ ESCs was achieved both in vitro and in vivo, indicated by reductions in total tracer lesion uptake, BLI signal and teratoma volume. As undifferentiated hSSTr2+ ESCs are not therapeutically relevant, they were differentiated towards CMs and injected in immune-deficient mice with a MI. Long-term cell survival could be monitored without uncontrolled cell proliferation. However, no improvement in the left ventricular ejection fraction was observed.Conclusion: We developed isogenic hSSTr2-expressing ESCs that allow noninvasive cell monitoring in the context of PSC-derived regenerative therapy. Furthermore, we are the first to use the hSSTr2 not only as an imaging reporter gene, but also as a suicide mechanism for radionuclide therapy in the setting of PSC-derived cell treatment

Realistic Calculation of the hep Astrophysical Factor

The astrophysical factor for the proton weak capture on 3He is calculated with correlated-hyperspherical-harmonics bound and continuum wave functions corresponding to a realistic Hamiltonian consisting of the Argonne v18 two-nucleon and Urbana-IX three-nucleon interactions. The nuclear weak charge and current operators have vector and axial-vector components, that include one- and many-body terms. All possible multipole transitions connecting any of the p-3He S- and P-wave channels to the 4He bound state are considered. The S-factor at a p-3He center-of-mass energy of 10 keV, close to the Gamow-peak energy, is predicted to be 10.1 10^{-20} keV b, a factor of five larger than the standard-solar-model value. The P-wave transitions are found to be important, contributing about 40 % of the calculated S-factor.Comment: 8 pages RevTex file, submitted to Phys. Rev. Let

System size and centrality dependence of charged hadron transverse momentum spectra in Au+Au and Cu+Cu collisions at sqrt(s) = 62.4 and 200 GeV

We present transverse momentum distributions of charged hadrons produced in Cu+Cu collisions at sqrt(s) = 62.4 and 200 GeV. The spectra are measured for transverse momenta of 0.25 < p_T < 5.0 GeV/c at sqrt(s) = 62.4 GeV and 0.25 < p_T < 7.0 GeV/c at sqrt(s) = 200 GeV, in a pseudo-rapidity range of 0.2 < eta < 1.4. The nuclear modification factor R_AA is calculated relative to p+p data at both collision energies as a function of collision centrality. At a given collision energy and fractional cross-section, R_AA is observed to be systematically larger in Cu+Cu collisions compared to Au+Au. However, for the same number of participating nucleons, R_AA is essentially the same in both systems over the measured range of p_T, in spite of the significantly different geometries of the Cu+Cu and Au+Au systems.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Let

System Size, Energy and Centrality Dependence of Pseudorapidity Distributions of Charged Particles in Relativistic Heavy Ion Collisions

We present the first measurements of the pseudorapidity distribution of primary charged particles in Cu+Cu collisions as a function of collision centrality and energy, \sqrtsnn = 22.4, 62.4 and 200 GeV, over a wide range of pseudorapidity, using the PHOBOS detector. Making a global comparison of Cu+Cu and Au+Au results, we find that the total number of produced charged particles and the rough shape (height and width) of the pseudorapidity distributions are determined by the number of nucleon participants. More detailed studies reveal that a more precise matching of the shape of the Cu+Cu and Au+Au pseudorapidity distributions over the full range of pseudorapidity occurs for the same Npart/2A value rather than the same Npart value. In other words, it is the collision geometry rather than just the number of nucleon participants that drives the detailed shape of the pseudorapidity distribution and its centrality dependence at RHIC energies.Comment: Submitted to Physical Review Letter

Identified charged antiparticle to particle ratios near midrapidity in Cu+Cu collisions at sqrt(s) = 62.4 and 200 GeV

Antiparticle to particle ratios for identified protons, kaons and pions at sqrt(s) = 62.4 and 200 GeV in Cu+Cu collisions are presented as a function of centrality for the midrapidity region of 0.2 < eta < 1.4. No strong dependence on centrality is observed. For the / ratio at ~ 0.51 GeV/c, we observe an average value of 0.50 +/- 0.003_(stat) +/- 0.04_(syst) and 0.77 +/- 0.008_(stat) +/- 0.05_(syst) for the 10% most central collisions of 62.4 and 200 GeV Cu+Cu, respectively. The values for all three particle species measured at sqrt(s) = 200 GeV are in agreement within systematic uncertainties with that seen in both heavier and lighter systems measured at the same RHIC energy. This indicates that system size does not appear to play a strong role in determining the midrapidity chemical freeze-out properties affecting the antiparticle to particle ratios of the three most abundant particle species produced in these collisions.Comment: 5 Pages, 4 figures Made changes to the figures to include the panel numbers. Slight changes to the text. Updated data points from other experiment

Centrality dependence of charged hadron transverse momentum spectra in d+Au collisions at sqrt(s_NN) = 200 GeV

We have measured transverse momentum distributions of charged hadrons produced in d+Au collisions at sqrt(s_NN) = 200 GeV. The spectra were obtained for transverse momenta 0.25 < p_T < 6.0 GeV/c, in a pseudorapidity range of 0.2 < eta < 1.4 in the deuteron direction. The evolution of the spectra with collision centrality is presented in comparison to p+pbarcollisions at the same collision energy. With increasing centrality, the yield at high transverse momenta increases more rapidly than the overall particle density, leading to a strong modification of the spectral shape. This change in spectral shape is qualitatively different from observations in Au+Au collisions at the same energy. The results provide important information for discriminating between different models for the suppression of high-p_T hadrons observed in Au+Au collisions.Comment: 5 pages, 4 figures, submitted to PR

Cluster properties from two-particle angular correlations in p+p collisions at s\sqrt{s} = 200 and 410 GeV

We present results on two-particle angular correlations in proton-proton collisions at center of mass energies of 200 and 410 GeV. The PHOBOS experiment at the Relativistic Heavy Ion Collider has a uniquely large coverage for charged particles, giving the opportunity to explore the correlations at both short- and long-range scales. At both energies, a complex two-dimensional correlation structure in $\Delta \eta$ and $\Delta \phi$ is observed. In the context of an independent cluster model of short-range correlations, the cluster size and its decay width are extracted from the two-particle pseudorapidity correlation function and compared with previous measurements in proton-proton and proton-antiproton collisions, as well as PYTHIA and HIJING predictions.Comment: 10 pages, 10 figures, submitted to Phys. Rev.

Endotoxin Induced Chorioamnionitis Prevents Intestinal Development during Gestation in Fetal Sheep

Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery. Prematurity and prenatal inflammation are associated with compromised postnatal developmental outcomes, of the intestinal immune defence, gut barrier function and the vascular system. We developed a sheep model to study how the antenatal development of the gut was affected by gestation and/or by endotoxin induced chorioamnionitis

The ZEPLIN-III dark matter detector: instrument design, manufacture and commissioning

We present details of the technical design and manufacture of the ZEPLIN-III dark matter experiment. ZEPLIN-III is a two-phase xenon detector which measures both the scintillation light and the ionisation charge generated in the liquid by interacting particles and radiation. The instrument design is driven by both the physics requirements and by the technology requirements surrounding the use of liquid xenon. These include considerations of key performance parameters, such as the efficiency of scintillation light collection, restrictions placed on the use of materials to control the inherent radioactivity levels, attainment of high vacuum levels and chemical contamination control. The successful solution has involved a number of novel design and manufacturing features which will be of specific use to future generations of direct dark matter search experiments as they struggle with similar and progressively more demanding requirements.Comment: 25 pages, 19 figures. Submitted to Astropart. Phys. Some figures down sampled to reduce siz