Minimum Information about a Biosynthetic Gene cluster

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.Chemistry and Chemical Biolog

A New Generation of a Statistical Computing Environment on the Net

With the availability of the net a new generation of computing environments has to be designed for a large scale of statistical tasks ranging from data analysis to highly interactive operations. It must combine the flexibility of multi window desktops with standard operations and interactive user driven actions. It must be equally well suited for first year students and for high demanding researchers. Its design must has various degrees of flexibility that allow to address different levels of user groups. We present here some ideas how a new generation of a computing environment can be used as a student front end tool for teaching elementary statistics as well as a research device for highly computer intensive tasks, e.g. for semiparametric analysis and bootstrapping. 1 The Net and an interactive Statistical Computing Environment First versions of interactive computing environments have been created in the mid eighties. At this time PCs were about to emerge as the standard machine for..

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts

In this article, Professor Franke asks and answers a seemingly simple question: why is sexual harassment a form of sex discrimination under Title VII of the Civil Rights Act of 1964? She argues that the link between sexual harassment and sex discrimination has been undertheorized b9 the Supreme Court. In the absence of a principled theory of the wrong of sexual harassment, Professor Franke argues that lower courts have developed a body of sexual harassment law that trivializes the legal norm against sex discrimination. After illustrating how the Supreme Court has not provided an adequate theory of sexual harassment as sex discrimination, she traces the theoretical arguments advanced by feminist scholars on behalf of a cause of action for sexual harassment under Title VII: 1) it violates formal equality principles; 2) its sexism lies in the fact that the conduct is sexual; and 3) sexual harassment is an example of the subordination of women by men. Professor Franke provides a critique of each of these accounts of sexual harassment, in part, by showing how each is unable to provide an account of whether same-sex sexual harassment should be actionable under Title VII. She argues that flaws in both the theory and the doctrine are amplified in the marginal cases of same-sex harassment. Professor Franke then argues that the discriminatory wrong of sexual harassment, between parties of different or same sexes, should be understood as a technology of sexism. That is, the sexism in sexual harassment lies in its power as a regulatory practice that feminizes women and masculinizes men, renders women sexual objects and men sexual subjects