Neuropsychological analysis of gait disturbances during dual task in MCI patients

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Awareness and cognitive rehabilitation in Alzheimer and frontotemporal dementia

peer reviewedINTRODUCTION Awareness influences the evolution of neurodegenerative dementias. We gathered participants’ and caregivers assessments of dependence in daily activities and we studied how each score would be related to next year participant autonomy, independently of other explicative variables. METHOD We retrospectively analyzed data from mildly demented participants with a clinical diagnosis of Alzheimer's disease (AD, n = 186) and frontotemporal dementia (FTD, n = 29) and their relatives. A research tool was used to assess participant dependence in 98 daily activities and associated caregiver burden. A discrepancy score between the patient's and relative's judgment was calculated to evaluate awareness of dependence in activities at baseline. This dependence scores, as well as sex, age, education, and 1 year difference in Mini-Mental State Examination were taken as possible explicative variables for dependence in activities adapted by therapists during a 1-year cognitive rehabilitation program. RESULTS Patients with FTD showed less awareness for daily dependence (discrepancy 20.9% vs. 11.8% in AD). Both groups benefited from cognitive rehabilitation (25% decrease in dependence) and subjective burden of relatives was decreased in both groups. In the AD group, there was a significant positive relationship between both caregiver (P < 0.001) and participant's (P < 0.02) evaluation of dependence in daily activities at inclusion and dependence of participants in adapted activities after 1 year. DISCUSSION Awareness of impairment in daily activities is a clinical symptom that is more important at inclusion in FTD than in AD. However, in participants with AD who, as a group, significantly benefit from a cognitive rehabilitation program, not only caregiver's but also participant's assessment of dependence at baseline is correlated to subsequent, next year greater dependence in daily activities adapted by the therapists. Although discrepant, both caregiver and participant evaluations appear to be important variables to understand the evolution and the benefit of care in participants at early stages of dementia

Training early Alzheimer patients to use a mobile phone

The mobile phone may be useful to keep in contact with spatially disoriented and memory impaired patients. In keeping with this idea, this study describes the training program developed to teach two patients with mild Alzheimer's disease (CI and ML) how to use their own mobile phone. Each training session was divided into two parts. In the first part, the spaced-retrieval technique was used to promote the consultation of a card pasted on the back of the phone. The card detailed each stage of phone utilization and which keys had to be pressed to call somebody. In the second part, the patients received repetitive exercises of calling based upon the errorless learning principle. At the end of three-months rehabilitation, the results showed different learning patterns for the patients. ML needed more spaced-retrieval sessions to spontaneously consult the card and to correctly use the phone, compared to CI However, by the repetition of calling exercises, both patients showed a decrease of instruction card consultation, whereas they were still able to correctly call somebody. This learning ability is hypothesized to be a consequence of a relatively preserved procedural memory in both patients. In conclusion, this study highlights the effectiveness of combined specific learning techniques for improving AD patient's autonomy in daily life activities

Efficacy of Cognitive Rehabilitation in Alzheimer Disease: A 1-Year Follow-Up Study

peer reviewedIntroduction: The benefit of cognitive rehabilitation (CR) for patients with early-stage Alzheimer disease (AD) remains difficult to assess. Method: An observational, prospective study was conducted in a sample of 52 patients with AD included in a clinical, individualized CR program. Cognitive rehabilitation consisted of 1 weekly session during 3 months at home, followed by 1 monthly contact for 9 months. Rehabilitation techniques were used by experienced therapists to adapt activities important for the patient. Evaluation of patient’s dependence in activities and objective and subjective caregiver’s burden was performed with a research quantitative scale immediately after the intervention and at 6-month and 1-year follow-up. Results: Analyses with repeated measure analysis of variance showed decreased patient’s dependence for adapted activities at 3 months, 6 months, and 1 year. Objective and subjective percentage of caregiver’s burden was also decreased at all evaluations with our research functional scale, while there was no change on Zarit’s burden scale. Global cognition slightly decreased over 1 year. Conclusions: This observational study in a clinical setting is in line with the benefit of CR for patients with mild AD reported in recent randomized controlled trials. The benefit obtained for adapted activities remained after 1 year, even if global cognition declined. Moreover caregiver’s burden related to all individually relevant daily activities (from a list of 98) evaluated within the CR program was decreased after 1 year. Those preliminary results emphasize the importance of choice for the measurement instrument to report CR efficacy and claim for further validation of such tools

A grid for a precise analysis of daily activities

peer reviewedAssessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients

Réadaptation cognitive d'activités de vie quotidienne dans la maladie d'Alzheimer

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