86 research outputs found
Using planar laser-induced fluorescence to study the phase transformations of two-component liquid and suspension droplets
Using the planar laser-induced fluorescence (PLIF), we performed experiments to determine evaporation dynamics of homogeneous and heterogeneous droplets of liquids, conditions of their boiling, and explosive breakup. For the 1β2 mm water droplets, the distribution of highly non-homogeneous and non-steady temperature field was detected by highspeed cross-correlation video recording and the Tema Automotive software.We identified highly nonlinear dependences of evaporation rate on heating temperature and time as well as water droplet size. For the two-component liquids and water-based suspensions of graphite, we revealed unsteady temperature fields and established mechanisms and regimes of the explosive breakup of the heterogeneous droplets when heated. The regimes differ in the number and dimensions of the emerging gasβliquid fragments as well as the durations of the main stages. The three regimes of warming-up and evaporation of the heterogeneous droplets have been obtained. The explosive breakup of droplets enables provision for the secondary atomization of the liquid with the emergence of an aerosol cloud. The surface area of the liquid increases several-fold. The temperature variations at the water/solid or water/flammable component interfaces were determined corresponding to each boiling and breakup regime. Using the PLIF, we studied reasons and mechanism of the explosive breakup of water droplets with single large carbonaceous inclusions when heated
ΠΠ± ΡΡΠΈΠΊΠ΅ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΉ ΠΈ ΡΡΠΈΠΊΠ΅ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΡΠΈ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠ² ΡΡΠΈΠΊΠΈ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΉ, Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
Π°ΠΌΠ΅ΡΠΈΠΊΠ°Π½ΡΠΊΠΈΠΌΠΈ ΡΡΠ΅Π½ΡΠΌΠΈ, ΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°ΡΡΡΡ ΡΠΎΡΠΊΠΈ ΠΏΠ΅ΡΠ΅ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ°ΠΌΠΈ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΡΡΠΈΠΊΠΎΠΉ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ±ΡΠ΅ΠΊΡΠ°. ΠΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ½ΡΡΠΈΡ "ΡΡΠΈΠΊΠ° ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΉ" ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ½ΡΡΠΈΡ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
. ΠΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅ΡΡΡ, ΡΡΠΎ ΠΊΠ»ΡΡΠ΅Π²ΠΎΠΉ ΡΠΈΠ³ΡΡΠΎΠΉ Π² Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΉ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ, ΡΠΎΠ·Π΄Π°ΡΡΠΈΠΉ Π·Π½Π°ΡΠ΅Π½ΠΈΡ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΉ ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ ΡΠΎΡΠΌ Π·Π½Π°ΠΊΠ° Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎΠΌ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅. Π‘Π΄Π΅Π»Π°Π½ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΠ°ΠΊΠΎΠΉ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ²ΡΠ·ΡΡΡΠΈΠΌ Π·Π²Π΅Π½ΠΎΠΌ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΠΏΡΠΈΠ½ΡΠΈΠΏΠ°ΠΌΠΈ ΡΡΠΈΠΊΠΈ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΉ, ΡΡΠΎ ΡΠΎΠ·Π΄Π°Π΅Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΊΠ»ΡΡΠ΅Π²ΡΡ
ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΉ ΡΡΠΈΠΊΠΈ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ
ΠΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ΄Π°ΠΆ ΡΠΎΠ²Π°ΡΠΎΠ² Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡΡ ΡΠΏΡΠΎΡΠ°
Π ΡΠ°Π±ΠΎΡΠ΅ Π°Π²ΡΠΎΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡ ΠΎΠ±Π·ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π² ΡΠ΅ΡΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΉΠ»Π°. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠ΅Π΄ΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ
ΠΎΡ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π΄Π°Π½Π½ΡΡ
ΡΠ°Π·ΡΠ°Π±Π°ΡΡΠ²Π°Π΅Ρ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΎΠ²Π°ΡΠΎΠ², ΠΈΠΌΠ΅ΡΡΠΈΡ
Π²ΡΡΠΎΠΊΡΡ ΡΠ΅Π½ΠΎΠ²ΡΡ ΡΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ ΡΠΏΡΠΎΡΠ°, ΠΈ Π²Π½Π΅Π΄ΡΡΠ΅Ρ Π² ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠΎΠ²Π°ΡΠ½ΡΠΌΠΈ Π·Π°ΠΏΠ°ΡΠ°ΠΌΠΈ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ.In the work, the author reviews the forecasting methods, gives the forecasting features associated with forecasting in the network of food retail. Based on the data provided by the company, he develops a mathematical model of goods with high price elasticity of demand and implements the companyβs inventory management process
ΠΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠ°Π΄ΠΈΠΉΠ½ΠΎΠ³ΠΎ Π³ΠΈΠ΄ΡΠ°Π²Π»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·ΡΡΠ²Π° ΠΏΠ»Π°ΡΡΠ° Π½Π° Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ ΡΠΊΠ²Π°ΠΆΠΈΠ½Π°Ρ Π½Π΅ΡΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ "Π₯" (Π’ΠΎΠΌΡΠΊΠ°Ρ ΠΎΠ±Π»Π°ΡΡΡ)
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΎΠΏΡΡΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ
ΡΠΊΠ²Π°ΠΆΠΈΠ½ Ρ ΠΠΠ Π Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ "Π₯" (Π’ΠΎΠΌΡΠΊΠ°Ρ ΠΎΠ±Π»Π°ΡΡΡ). Π Ρ
ΠΎΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ, Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄ΠΎΠ±ΡΠ°Π½Ρ 65 ΡΠΊΠ²Π°ΠΆΠΈΠ½-ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΠΎΠ², Π½Π° ΠΊΠΎΡΠΎΡΡΡ
ΠΌΠΎΠΆΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΡΠΎΠ²Π΅ΡΡΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡ ΠΠ Π. ΠΠΎΠΌΠΈΠΌΠΎ ΡΡΠΎΠ³ΠΎ, Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΠ Π Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡΡ
Π°Π½Π°Π»ΠΎΠ³ΠΎΠ², ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ ΠΏΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ.The paper presents an analysis of the experience of using horizontal wells with multistage fracturing at the "X" field (Tomsk region). In the course of the work, methods were proposed, on the basis of which 65 candidate wells were selected, on which it is possible to effectively carry out hydraulic fracturing. In addition, based on the analysis of hydraulic fracturing in analogous fields, measures were proposed to improve the efficiency of the operation
ΠΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡ ΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΠΌΠΈ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡΠΌΠΈ
Π‘ΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ°Π»ΠΈ Β«ΠΠΎΡΠΏΡΡΒ»
Π‘ΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ°Π»ΠΈ Β«ΠΠΎΡΠΏΡΡΒ».
Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°Π·Π΄Π΅Π», ΠΠΎΠ½ΡΡΡΡΠΊΡΠΎΡΡΠΊΠΈΠΉ ΡΠ°Π·Π΄Π΅Π», Π’Π΅Ρ
Π½ΠΈΠΊΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ ,Π‘ΠΎΡΠΈΠ°Π»ΡΠ½Π°Ρ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΡ.Perfection of technological process of manufacturing parts "Housing".
Technological section, design section, Feasibility Study, Social Responsibility
ΠΠ°Π΄ΡΠΎΠ²ΡΠΉ ΡΠ΅Π·Π΅ΡΠ² Π² ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΎΠΌ (Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΠΠ Β«Π’ΠΎΠΌΡΠΊΠΠΠΠΠ½Π΅ΡΡΡΒ»)
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π±ΠΎΡΠ° Ρ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ.
Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ½ΠΎΠ² ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°Π΄ΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅Π·Π΅ΡΠ²Π° Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ; ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ Π°Π½Π°Π»ΠΈΠ· ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ² ΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°Π΄ΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅Π·Π΅ΡΠ²Π°.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΎΠΏΠ΅ΡΠ΅ΠΆΠ°ΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°Π±ΠΎΡΡ Ρ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ Β«ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠ΅ΡΒ»
Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ: Π΄Π°Π½Π½Π°Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΎΠΏΠ΅ΡΠ΅ΠΆΠ°ΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°Π±ΠΎΡΡ Ρ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ Β«ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠ΅ΡΒ» ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½Π° ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ Π² ΠΠΠ Β«Π’ΠΎΠΌΡΠΊΠΠΠΠΠ½Π΅ΡΡΡΒ».
ΠΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ: Π΄Π°Π½Π½Π°Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΎΠΏΠ΅ΡΠ΅ΠΆΠ°ΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ°Π±ΠΎΡΡ Ρ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ Β«ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅Π½Π΅Π΄ΠΆΠ΅ΡΒ» ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° Π½Π° ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΈ .The object of research is the work with the personnel reserve of the company.
The aim of the study is to examine the theoretical foundations and practical functioning of the personnel reserve mechanism on the example of the organization; identification and analysis of the prospects and issues related to the further development of the formation of personnel reserve.
The research methodology of advanced training and development work with the personnel reserve "effective manager" has been developed
Degree of implementation: the technique of advancing training and development work with the personnel reserve "effective manager" is applied and used in JSC "TomskNIPIneft".
Scope: This method of advancing training and development work with the personnel reserve "effective manager" can be used i
Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma
Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma
Targeted inhibition of the c-Jun N-terminal kinases (JNKs) has shown therapeutic potential in intrahepatic cholangiocarcinoma (CCA)-related tumorigenesis. However, the cell-type-specific role and mechanisms triggered by JNK in liver parenchymal cells during CCA remain largely unknown. Here, we aimed to investigate the relevance of JNK1 and JNK2 function in hepatocytes in two different models of experimental carcinogenesis, the dethylnitrosamine (DEN) model and in nuclear factor kappa B essential modulator (NEMO)(hepatocyte-specific knockout (Deltahepa)) mice, focusing on liver damage, cell death, compensatory proliferation, fibrogenesis, and tumor development. Moreover, regulation of essential genes was assessed by reverse transcription polymerase chain reaction, immunoblottings, and immunostainings. Additionally, specific Jnk2 inhibition in hepatocytes of NEMO(Deltahepa)/JNK1(Deltahepa) mice was performed using small interfering (si) RNA (siJnk2) nanodelivery. Finally, active signaling pathways were blocked using specific inhibitors. Compound deletion of Jnk1 and Jnk2 in hepatocytes diminished hepatocellular carcinoma (HCC) in both the DEN model and in NEMO(Deltahepa) mice but in contrast caused massive proliferation of the biliary ducts. Indeed, Jnk1/2 deficiency in hepatocytes of NEMO(Deltahepa) (NEMO(Deltahepa)/JNK(Deltahepa)) animals caused elevated fibrosis, increased apoptosis, increased compensatory proliferation, and elevated inflammatory cytokines expression but reduced HCC. Furthermore, siJnk2 treatment in NEMO(Deltahepa)/JNK1(Deltahepa) mice recapitulated the phenotype of NEMO(Deltahepa)/JNK(Deltahepa) mice. Next, we sought to investigate the impact of molecular pathways in response to compound JNK deficiency in NEMO(Deltahepa) mice. We found that NEMO(Deltahepa)/JNK(Deltahepa) livers exhibited overexpression of the interleukin-6/signal transducer and activator of transcription 3 pathway in addition to epidermal growth factor receptor (EGFR)-rapidly accelerated fibrosarcoma (Raf)-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) cascade. The functional relevance was tested by administering lapatinib, which is a dual tyrosine kinase inhibitor of erythroblastic oncogene B-2 (ErbB2) and EGFR signaling, to NEMO(Deltahepa)/JNK(Deltahepa) mice. Lapatinib effectively inhibited cystogenesis, improved transaminases, and effectively blocked EGFR-Raf-MEK-ERK signaling.
Conclusion: We define a novel function of JNK1/2 in cholangiocyte hyperproliferation. This opens new therapeutic avenues devised to inhibit pathways of cholangiocarcinogenesis
Π‘ΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΠΎΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΠ΄Π²ΠΎΠ΄Π½ΡΡ ΠΏΠ΅ΡΠ΅Ρ ΠΎΠ΄ΠΎΠ² ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π±ΡΡΠ΅Π½ΠΈΡ
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΎΠΊΠ»Π°Π΄ΠΊΠΈ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄ΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΠΎ-Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π±ΡΡΠ΅Π½ΠΈΡ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΡΡΠΎΠΉΡΡΠ²Π°.
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±Π΅ΡΡΡΠ°Π½ΡΠ΅ΠΉΠ½ΠΎΠΉ ΠΏΡΠΎΠΊΠ»Π°Π΄ΠΊΠΈ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄ΠΎΠ², ΡΠ°ΡΡΠ΅Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΏΠΎΠ΄Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π°, ΠΏΠΎΠ΄Π±ΠΎΡ Π·Π°ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΡΡΠΎΠΉΡΡΠ²Π°, ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½Π½ΠΎ-Π΄Π΅ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎ-ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Ansys.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ΠΎΠ±ΡΠ°Π½Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΏΠΎΠ΄Π²ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π°, ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΊΠΎΠ½Π΅ΡΠ½ΠΎ-ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Ansys ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ Π½Π°ΠΏΡΡΠΆΠ΅Π½Π½ΠΎ-Π΄Π΅ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ½ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΡΡΠ±ΠΎΠΏΡΠΎΠ²ΠΎΠ΄Π° Ρ Π·Π°ΡΠΈΡΠ½ΡΠΌ ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ ΠΈ Π±Π΅Π· Π½Π΅Π³ΠΎ.The purpose of the work is to develop recommendations for the application of pipeline laying technology by the method of horizontal directional drilling using a protective device.
In the process of the research, the existing methods of trenchless pipeline laying, the calculation of the main characteristics of the underwater crossing, the selection of the protective device, the study of the stress-strain state of the pipeline using finite element modeling in the software complex Ansys were compared. As a result of the research, optimal parameters of the underwater transition were selected, the finite element method in the software complex Ansys determined the stress-strain state of the pipeline with the protective device and without it
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