A fundamental study on the cytostatic action of sesquiterpene lactones from Eupatorium cannabinum L

The sesquiterpene lactones form a large group of biologically active plant constituents. In this thesis several aspects of the cytostatic action of sesquiterpene lactones, isolated from Eupatorium cannabinum L. (waterhemp), Asteraceae, are described. Using both in vitro and in vivo test models, structure-activity relationships of some naturally occurring sesquiterpene lactones and semi-synthetic derivatives were studied. Furthermore, the possible mechanism of action of these compounds has been investigated. Eupatoriopicrin, the main sesquiterpene lactone of E. cannabinum, was used as model. compound. ... Zie: Summary

Body Sculpting

The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs