British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Behçets 2024

The overall objective of the current iteration of this living guideline is to provide up-to-date, evidence-based recommendations for the management of Behçets disease/syndrome (henceforth termed ‘Behçets’ for simplicity, and as approved by the patient support group) in adults, children and young people. The document aims to: *offer an appraisal of all relevant literature up to 25 August 2023 focusing on any key developments // *address important, practical clinical questions relating to the primary guideline objective// *provide guideline recommendations and appropriate research recommendations.// The guideline is presented as a detailed review with highlighted recommendations for practical use in all appropriate community and hospital settings (see Section 3.0), in addition to a patient information leaflet (PIL; available on the BAD website: www.skinhealthinfo.org.uk)

Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature

Objectives. To describe 2 cases of thyrotoxic periodic paralysis. Methods. We report of 2 cases of thyrotoxic periodic paralysis in 2 individuals from 2 different backgrounds with emphasis on their presentation and treatment. We also conducted a literature search to put together an update review of thyrotoxic periodic paralysis. Results. A 47-year-old Chinese and 28-year-old Caucasian male presented with profound yet reversible weakness associated with hypokalemia on admission bloods and thyrotoxicosis. Both were given definitive therapy to prevent recurrence of attacks with any future relapse of thyrotoxicosis. Conclusion. Thyrotoxic periodic paralysis (TPP) is a rare but potentially serious complication of thyrotoxicosis resulting in temporary but severe muscle weakness. Recent discovery of a novel mutation in the KCNJ18 gene which codes for an inwardly rectifying potassium channel and is controlled by thyroid hormones may provide greater insight into the pathogenesis of TPP