2 research outputs found
The effect of prophylactic cranial irradiation (PCI) for young stage III NSCLC patients: Subgroup analyses of the NVALT-11/DLCRG-02 study
Background: The NVALT-11/DLCRG-02 phase III study compared PCI to observation
after chemo-radiotherapy (RT) for stage III NSCLC and showed a significant decrease
in the cumulative incidence of symptomatic brain metastases (BM) in the PCI arm at
two years (7% vs 27% [HR 0.23]). We here performed exploratory subgroup analyses.
Methods: Two year cumulative incidence rates were calculated and competing risk
regression, with death of any cause as competing risk, was used to examine the time to
symptomatic BM in the following subgr