Return to Sports and Physical Activity After Total and Unicondylar Knee Arthroplasty: A Systematic Review and Meta-Analysis

People today are living longer and want to remain active. While obesity is becoming an epidemic, the number of patients suffering from osteoarthritis (OA) is expected to grow exponentially in the coming decades. Patients with OA of the knee are progressively being restricted in their activities. Since a knee arthroplasty (KA) is a well accepted, cost-effective intervention to relieve pain, restore function and improve health-related quality of life, indications are expanding to younger and more active patients. However, evidence concerning return to sports (RTS) and physical activity (PA) after KA is sparse. Our aim was to systematically summarise the available literature concerning the extent to which patients can RTS and be physically active after total (TKA) and unicondylar knee arthroplasty (UKA), as well as the time it takes. PRISMA guidelines were followed and our study protocol was published online at PROSPERO under registration number CRD42014009370. Based on the keywords (and synonyms of) 'arthroplasty', 'sports' and 'recovery of function', the databases MEDLINE, Embase and SPORTDiscus up to January 5, 2015 were searched. Articles concerning TKA or UKA patients who recovered their sporting capacity, or intended to, were included and were rated by outcomes of our interest. Methodological quality was assessed using Quality in Prognosis Studies (QUIPS) and data extraction was performed using a standardised extraction form, both conducted by two independent investigators. Out of 1115 hits, 18 original studies were included. According to QUIPS, three studies had a low risk of bias. Overall RTS varied from 36 to 89% after TKA and from 75 to >100% after UKA. The meta-analysis revealed that participation in sports seems more likely after UKA than after TKA, with mean numbers of sports per patient postoperatively of 1.1-4.6 after UKA and 0.2-1.0 after TKA. PA level was higher after UKA than after TKA, but a trend towards lower-impact sports was shown after both TKA and UKA. Mean time to RTS after TKA and UKA was 13 and 12 weeks, respectively, concerning low-impact types of sports in more than 90 % of cases. Low- and higher-impact sports after both TKA and UKA are possible, but it is clear that more patients RTS (including higher-impact types of sports) after UKA than after TKA. However, the overall quality of included studies was limited, mainly because confounding factors were inadequately taken into account in most studie

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Fluorescence grid analysis for the evaluation of piecemeal surgery in sinonasal inverted papilloma:a proof-of-concept study

PURPOSE: Local recurrence occurs in ~ 19% of sinonasal inverted papilloma (SNIP) surgeries and is strongly associated with incomplete resection. During surgery, it is technically challenging to visualize and resect all SNIP tissue in this anatomically complex area. Proteins that are overexpressed in SNIP, such as vascular endothelial growth factor (VEGF), may serve as a target for fluorescence molecular imaging to guide surgical removal of SNIP. A proof-of-concept study was performed to investigate if the VEGF-targeted near-infrared fluorescent tracer bevacizumab-800CW specifically localizes in SNIP and whether it could be used as a clinical tool to guide SNIP surgery.METHODS: In five patients diagnosed with SNIP, 10 mg of bevacizumab-800CW was intravenously administered 3 days prior to surgery. Fluorescence molecular imaging was performed in vivo during surgery and ex vivo during the processing of the surgical specimen. Fluorescence signals were correlated with final histopathology and VEGF-A immunohistochemistry. We introduced a fluorescence grid analysis to assess the fluorescence signal in individual tissue fragments, due to the nature of the surgical procedure (i.e., piecemeal resection) allowing the detection of small SNIP residues and location of the tracer ex vivo.RESULTS: In all patients, fluorescence signal was detected in vivo during endoscopic SNIP surgery. Using ex vivo fluorescence grid analysis, we were able to correlate bevacizumab-800CW fluorescence of individual tissue fragments with final histopathology. Fluorescence grid analysis showed substantial variability in mean fluorescence intensity (FImean), with SNIP tissue showing a median FImean of 77.54 (IQR 50.47-112.30) compared to 35.99 (IQR 21.48-57.81) in uninvolved tissue (p &lt; 0.0001), although the diagnostic ability was limited with an area under the curve of 0.78.CONCLUSIONS: A fluorescence grid analysis could serve as a valid method to evaluate fluorescence molecular imaging in piecemeal surgeries. As such, although substantial differences were observed in fluorescence intensities, VEGF-A may not be the ideal target for SNIP surgery.TRIAL REGISTRATION: NCT03925285.</p

Full 3-D digital planning of implant-supported bridges in secondary mandibular reconstruction with prefabricated fibula free flaps

Objectives In the reconstruction of maxillary or mandibular continuity defects in dentate patients, the most favourable treatment is placement of implant-retained crowns or bridges in a bone graft that reconstructs the defect. Proper implant positioning is often impaired by suboptimal placement of the bone graft. This case describes a new technique of a full digitally planned, immediate restoration, two-step surgical approach for reconstruction of a mandibular defect using a free vascularised fibula graft with implants and a bridge. Procedure A 68-year-old male developed osteoradionecrosis of the mandible. The resection, cutting and implant placement in the fibula were virtually planned. Cutting and drilling guides were 3-D printed, and the bridge was computer aided design-computer aided manufacturing (CAD-CAM) milled. During the first surgery, two implants were placed in the fibula according to the digital planning, and the position of the implants was scanned using an intra-oral optical scanner. During the second surgery, a bridge was placed on the implants, and the fibula was harvested and fixed in the mandibular defect, guided by the occlusion of the bridge. Conclusion Three-dimensional planning allowed for positioning of a fibula bone graft by means of an implant-supported bridge, which resulted in a functional position of the graft and bridge.</p

Prefabricated fibula free flaps in reconstruction of maxillofacial defects:Two cases of transplanting a fractured fibula

BACKGROUND: The two-staged prefabricated vascularized fibula free flap is used in maxillofacial reconstruction. We describe the possible cause and management of two cases of fibula fracture after implant placement.METHODS: The patients were treated with two-stage reconstruction with a prefabricated vascularized fibula free flap. Six dental implants were placed in both fibulas. Fibula fractures occurred during the osseointegration period before the second procedure. The reconstruction was continued as planned.RESULTS: Both fibulas fractured in the distal segment, possibly due to a thinner cortex more distally. Harvesting of a fractured fibula flap is more difficult than normally due to callus formation and fibrosis. Both transplants became fully functional with extended healing and additional surgery.CONCLUSION: The fracture apparently did not compromise the vascularisation of the fibula and proved still sufficient for successful harvest and transfer of the flap. The patient should be made aware that additional corrective surgery may be indicated.</p