Molecular changes in the adrenal medulla and brain following glucoprivation

Glucoprivation or hypoglycaemia evokes a complex array of counterregulatory responses which include autonomic, neuroendocrine and behavioural changes in order to maintain blood glucose levels. Catecholaminergic neurons of the rostral ventrolateral medulla activate adrenal adrenergic chromaffin cells to secrete adrenaline which mobilises glucose. Our aim was to determine the molecular changes and their timecourse in the adrenal medulla and brainstem regions in order to understand the cellular mechanisms altered in response to glucoprivation.2 page(s