Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications

The definitive version is available at www.blackwell-synergy.comA large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have a variety of actions including antibiotic and anticancer activities and the inhibition of neuronal nitric oxide synthase. We have investigated the structure–activity relationship of citropin 1.1, a broad-spectrum antibiotic and anticancer agent that also causes inhibition of neuronal nitric oxide synthase, by making a number of synthetically modified analogues. Citropin 1.1 has been shown previously to form an amphipathic α-helix in aqueous trifluoroethanol. The results of the structure–activity studies indicate the terminal residues are important for bacterial activity and increasing the overall positive charge, while maintaining an amphipathic distribution of residues, increases activity against Gram-negative organisms. Anticancer activity generally mirrors antibiotic activity suggesting a common mechanism of action. The N-terminal residues are important for inhibition of neuronal nitric oxide synthase, as is an overall positive charge greater than three. The structure of one of the more active synthetic modifications (A4K14-citropin 1.1) was determined in aqueous trifluoroethanol, showing that this peptide also forms an amphipathic α-helix.Jason Doyle, Craig S. Brinkworth, Kate L. Wegener, John A. Carver, Lyndon E. Llewellyn, Ian N. Olver, John H. Bowie, Paul A. Wabnitz, Michael J. Tyle

Cluster analysis

Trabajo de investigaciónSe desarrolló un Componente Web de Clustering para Análisis de Datos el cual permite ingresar mediante una interfaz web y/o una API un conjunto de datos que son analizados mediante técnicas de clustering, estas técnicas permiten realizar agrupamiento de datos basados en sus características, y así arrojar un resultado que relaciona dichos datos. Lo anterior, busca proveer a la Universidad de una herramienta que permita de manera general, práctica y gratuita, realizar análisis de datos basados en clustering para cualquier estudio de investigación.INTRODUCCIÓN 1. GENERALIDADES 2. OBJETIVOS DEL PROYECTO 3. MARCO REFERENCIAL 4. MARCO CONCEPTUAL 5. METODOLOGÍA 6. DESARROLLO DEL PROYECTO 7. RESULTADOS 8. CONCLUSIONES BIBLIOGRAFÍA ANEXOSPregradoIngeniero de Sistema