Understanding Coordination Support of Enterprise Architecture Management – Empirical Analysis and Implications for Practice

Enterprise architecture management (EAM) is a means to guide the consistent evolution of business and IT artifacts from an enterprise-wide perspective. This paper aims at understanding the means by which EAM supports this coordination task. Informed by theory of coordination and based on empirical data (n=95) we group participating enterprises in different clusters: (1) non-coordinators, (2) dominators and (3) negotiators. We find that a similar awareness of opportunities exists in all three clusters, yet there are gaps in the realization of EAM coordination support: non-coordinators show the lowest realization, negotiators the highest. Based on this clustering and two follow-up focus groups, we provide implications about the occurrence of the clusters in enterprises and on further EAM development options

Single-molecule conductance studies on quasi- and metallaaromatic dibenzoylmethane coordination compounds and their aromatic analogs

The ability to predict the conductive behaviour of molecules, connected to macroscopic electrodes, represents a crucial prerequisite for the design of nanoscale electronic devices. In this work, we investigate whether the notion of a negative relation between conductance and aromaticity (the so-called NRCA rule) also pertains to quasi-aromatic and metallaaromatic chelates derived from dibenzoylmethane (DBM) and Lewis acids (LAs) that either do or do not contribute two extra dπ electrons to the central resonance-stabilised β-ketoenolate binding pocket. We therefore synthesised a family of methylthio-functionalised DBM coordination compounds and subjected them, along with their truly aromatic terphenyl and 4,6-diphenylpyrimidine congeners, to scanning tunneling microscope break-junction (STM-BJ) experiments on gold nanoelectrodes. All molecules share the common motif of three π-conjugated, six-membered, planar rings with a meta-configuration at the central ring. According to our results, their molecular conductances fall within a factor of ca. 9 in an ordering aromatic < metallaaromatic < quasi-aromatic. The experimental trends are rationalised by quantum transport calculations based on density functional theory (DFT)

Enantioselective Total Synthesis of (‐)‐Finerenone using Asymmetric Transfer Hydrogenation

(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6‐step synthesis of (−)‐finerenone, which features an enantioselective partial transfer hydrogenation of a naphthyridine using a chiral phosphoric acid catalyst with a Hantzsch ester. The process is complicated by the fact that the naphthyridine exists as a mixture of two atropisomers that react at different rates and with different selectivities. The intrinsic kinetic resolution was converted into a kinetic dynamic resolution at elevated temperature, which enabled us to obtain (−)‐finerenone in both high yield and high enantioselectivity. DFT calculations have revealed the origin of selectivity.<br/