How Attitude Impacts IT Implementation Quality: An Exploratory Investigation of the Small Business Entrepreneur

Theories concerning the entrepreneur’s attitudes towards IT are important because studies show that the entrepreneur’s positive attitude towards IT is a key factor in achieving a high quality IT implementation in his/her business. Our study, based on data from multiple cases, supports this contention. Surprisingly, the data shows that those with negative attitudes towards IT also achieve high quality IT implementations. Those with uncertain attitudes towards IT had low quality IT implementations in their businesses. The results of this study yield some useful propositions: the most interesting is the importance of entrepreneurs with negative attitudes to rely on modern management policies in order to achieve a higher quality implementation

It’s Time! Revising the Factors that Impact Computer-based Training Application Development for an Aging Population

This paper discusses the results of a literature survey that identifies key factors related to the development of high quality computer-based training (CBT) applications. A special focus of this study is on training older adults. Analysis of case study data identifies how a CBT application is used by an 83 year old man to increase his skill and personal competitive advantage. This study begins to explore the concerns of the elderly using CBT applications. A framework is developed that may be used by application developers to help support training objectives in the context of an aging population

Genes Encoding Several Poly (ADP-Ribose) Glycohydrolase (PARG) Enzymes, the Proteins and Fragments Thereof, and Antibodies Immnoreactive Therewith

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body\u27s response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods for inhibiting PARG expression or overexpressing PARG in a subject for therapeutic benefit are described. Exemplary of PARG inhibitors are anti-sense oligonucleotides. The invention has implications for treatment of neoplastic disorder, heart attack, stroke, and neurodegenerative diseases. Methods for detecting a mutant PARG allele are also described. Antibodies immunoreactive with PARGs and fragments thereof are described

Genes Encoding Several Poly (ADP-Ribose) Glycohydrolase (PARG) Enzymes, the Proteins and Fragments Thereof, and Antibodies Immnoreactive Therewith

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body\u27s response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods for inhibiting PARG expression or overexpressing PARG in a subject for therapeutic benefit are described. Exemplary of PARG inhibitors are anti-sense oligonucleotides. The invention has implications for treatment of neoplastic disorder, heart attack, stroke, and neurodegenerative diseases. Methods for detecting a mutant PARG allele are also described. Antibodies immunoreactive with PARGs and fragments thereof are described

Genes Encoding Several Poly (ADP-Ribose) Glycohydrolase (PARG) Enzymes, the Proteins and Fragments Thereof, and Antibodies Immunoreactive Therewith

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body\u27s response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods for inhibiting PARG expression or overexpressing PARG in a subject for therapeutic benefit are described. Exemplary of PARG inhibitors are anti-sense oligonucleotides. The invention has implications for treatment of neoplastic disorder, heart attack, stroke, and neurodegenerative diseases. Methods for detecting a mutant PARG allele are also described. Antibodies immunoreactive with PARGs and fragments thereof are described

Genes Encoding Several Poly (ADP-Ribose) Glycohydrolase (PARG) Enzymes, the Proteins and Fragments Thereof, and Antibodies Immnoreactive Therewith

The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body\u27s response to neoplastic disorder inducing agents and oxidative stress. Expression vectors containing the cDNAs and cells transformed with the vectors are described. Probes and primers that hybridize with the cDNAs are described. Expression of the cDNA in E. coli results in an enzymatically active protein of about 111 kDa and an active fragment of about 59 kDa. Methods for inhibiting PARG expression or overexpressing PARG in a subject for therapeutic benefit are described. Exemplary of PARG inhibitors are anti-sense oligonucleotides. The invention has implications for treatment of neoplastic disorder, heart attack, stroke, and neurodegenerative diseases. Methods for detecting a mutant PARG allele are also described. Antibodies immunoreactive with PARGs and fragments thereof are described