Shaftesbury on Persons, Personal Identity, and Character Development

Shaftesbury’s major work Characteristicks of Men, Manners, Opinions, Times was one of the most influential English works in the eighteenth century. This paper focuses on his contributions to debates about persons and personal identity and shows that Shaftesbury regards metaphysical questions of personal identity as closely connected with normative questions of character development. I argue that he is willing to accept that persons are substances and that he takes their continued existence for granted. He sees the need to supplement metaphysical debates of personal identity and believes that we have to turn to the character that is realized by a substance if we want to understand who we are. For Shaftesbury persons have a particular character, can act, and govern themselves. I propose that Shaftesbury’s approach to persons has a developmental dimension, which is meant to encourage personal development and improvement of character. The developmental dimension can be understood as an intellectual journey that invites us to search for our true self, to develop our character, and to seek happiness, which ultimately involves understanding our place as persons in the order of the universe. I show that my developmental interpretation is preferable to other existing interpretations

Quantum Structure of Space Near a Black Hole Horizon

We describe a midi-superspace quantization scheme for generic single horizon black holes in which only the spatial diffeomorphisms are fixed. The remaining Hamiltonian constraint yields an infinite set of decoupled eigenvalue equations: one at each spatial point. The corresponding operator at each point is the product of the outgoing and ingoing null convergences, and describes the scale invariant quantum mechanics of a particle moving in an attractive $1/X^2$ potential. The variable $X$ that is analoguous to particle position is the square root of the conformal mode of the metric. We quantize the theory via Bohr quantization, which by construction turns the Hamiltonian constraint eigenvalue equation into a finite difference equation. The resulting spectrum gives rise to a discrete spatial topology exterior to the horizon. The spectrum approaches the continuum in the asymptotic region.Comment: References added and typos corrected. 21 pages, 1 figur

TOUCHtr4ck: democratic collaborative music

When electronic musicians compose collaboratively, they typically use their own single-user musical controllers. It may, therefore, be useful to develop novel controllers that support collaborative workflows and democratic principles. After describing the design principles for developing such controllers, we present TOUCHtr4ck, a prototype multi-touch system designed to facilitate such democratic relationships. Informal testing has revealed that this approach does facilitate democratic and collaborative music making, and can produce creative musical results

Am I my brother’s keeper? on personal identity and responsibility

The psychological continuity theory of personal identity has recently been accused of not meeting what is claimed to be a fundamental requirement on theories of identity - to explain personal moral responsibility. Although they often have much to say about responsibility, the charge is that they cannot say enough. I set out the background to the charge with a short discussion of Locke and the requirement to explain responsibility, then illustrate the accusation facing the theory with details from Marya Schechtman. I aim some questions at the challengers' reading of Locke, leading to an argument that the psychological continuity theory can say all that it needs to say about responsibility, and so is not in any grave predicament, at least not with regard to this particular charge.Web of Scienc

Gauge symmetry breaking and topological quantization for the Pauli Hamiltonian

We discuss the Pauli Hamiltonian within a ${SU(2)}$ gauge theory interpretation, where the gauge symmetry is broken. This interpretation carries directly over to the structural inversion asymmetric spin-orbit interactions in semiconductors and offers new insight into the problem of spin currents in the condensed matter environment. The central results is that symmetry breaking leads to zero spin conductivity in contrast to predictions of Gauge symmetric treatments. Computing the translation operator commutation relations comprising the simplest possible structural inversion asymmetry due to an external electric field, we derive a new condition for orbit quantization. The relation between the topological nature of this effect is consistent with our non-Abelian gauge symmetry breaking scenario.Comment: 7 pages, 1 figur

Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT

<p>Abstract</p> <p>Background</p> <p>Once-daily (QD) ritonavir 100 mg-boosted fosamprenavir 1400 mg (FPV/r100) or atazanavir 300 mg (ATV/r100), plus tenofovir/emtricitabine (TDF/FTC) 300 mg/200 mg, have not been compared as initial antiretroviral treatment. To address this data gap, we conducted an open-label, multicenter 48-week study (ALERT) in 106 antiretroviral-naïve, HIV-infected patients (median HIV-1 RNA 4.9 log₁₀copies/mL; CD4+ count 191 cells/mm³) randomly assigned to the FPV/r100 or ATV/r100 regimens.</p> <p>Results</p> <p>At baseline, the FPV/r100 or ATV/r100 arms were well-matched for HIV-1 RNA (median, 4.9 log₁₀copies/mL [both]), CD4+ count (mean, 176 vs 205 cells/mm³). At week 48, intent-to-treat: missing/discontinuation = failure analysis showed similar responses to FPV/r100 and ATV/r100 (HIV-1 RNA < 50 copies/mL: 75% (40/53) vs 83% (44/53), p = 0.34 [Cochran-Mantel-Haenszel test]); mean CD4+ count change-from-baseline: +170 vs +183 cells/mm³, p = 0.398 [Wilcoxon rank sum test]). Fasting total/LDL/HDL-cholesterol changes-from-baseline were also similar, although week 48 median fasting triglycerides were higher with FPV/r100 (150 vs 131 mg/dL). FPV/r100-treated patients experienced fewer treatment-related grade 2–4 adverse events (15% vs 57%), with differences driven by ATV-related hyperbilirubinemia. Three patients discontinued TDF/FTC because their GFR decreased to <50 mL/min.</p> <p>Conclusion</p> <p>The all-QD regimens of FPV/r100 and ATV/r100, plus TDF/FTC, provided similar virologic, CD4+ response, and fasting total/LDL/HDL-cholesterol changes through 48 weeks. Fewer FPV/r100-treated patients experienced treatment-related grade 2–4 adverse events.</p

Numerical Evolution of General Relativistic Voids

In this paper, we study the evolution of a relativistic, superhorizon-sized void embedded in a Friedmann-Robertson-Walker universe. We numerically solve the spherically symmetric general relativistic equations in comoving, synchronous coordinates. Initially, the fluid inside the void is taken to be homogeneous and nonexpanding. In a radiation- dominated universe, we find that radiation diffuses into the void at approximately the speed of light as a strong shock---the void collapses. We also find the surprising result that the cosmic collapse time (the $1^{\rm st}$-crossing time) is much smaller than previously thought, because it depends not only on the radius of the void, but also on the ratio of the temperature inside the void to that outside. If the ratio of the initial void radius to the outside Hubble radius is less than the ratio of the outside temperature to that inside, then the collapse occurs in less than the outside Hubble time. Thus, superhorizon-sized relativistic void may thermalize and homogenize relatively quickly. These new simulations revise the current picture of superhorizon-sized void evolution after first-order inflation.Comment: 37 pages plus 12 figures (upon request-- [email protected]) LaTeX, FNAL-PUB-93/005-

Universal Correlations in Pion-less EFT with the Resonating Group Model: Three and Four Nucleons

The Effective Field Theory "without pions" at next-to-leading order is used to analyze universal bound state and scattering properties of the 3- and 4-nucleon system. Results of a variety of phase shift equivalent nuclear potentials are presented for bound state properties of 3H and 4He, and for the singlet S-wave 3He-neutron scattering length a_0(3He-n). The calculations are performed with the Refined Resonating Group Method and include a full treatment of the Coulomb interaction and the leading-order 3-nucleon interaction. The results compare favorably with data and values from AV18(+UIX) model calculations. A new correlation between a_0(3He-n) and the 3H binding energy is found. Furthermore, we confirm at next-to-leading order the correlations, already found at leading-order, between the 3H binding energy and the 3H charge radius, and the Tjon line. With the 3H binding energy as input, we get predictions of the Effective Field Theory "without pions" at next-to-leading order for the root mean square charge radius of 3H of (1.6\pm 0.2) fm, for the 4He binding energy of (28\pm 2.5) MeV, and for Re(a_0(3He-n)) of (7.5\pm 0.6)fm. Including the Coulomb interaction, the splitting in binding energy between 3H and 3He is found to be (0.66\pm 0.03) MeV. The discrepancy to data of (0.10\mp 0.03) MeV is model independently attributed to higher order charge independence breaking interactions. We also demonstrate that different results for the same observable stem from higher order effects, and carefully assess that numerical uncertainties are negligible. Our results demonstrate the convergence and usefulness of the pion-less theory at next-to-leading order in the 4He channel. We conclude that no 4-nucleon interaction is needed to renormalize the theory at next-to-leading order in the 4-nucleon sector.Comment: 24 pages revtex4, including 8 figures as .eps files embedded with includegraphicx, leading-order results added, calculations include the LO three-nucleon interaction explicitly, comment on Wigner bound added, minor modification

Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain

Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis xpt-pbuX operon, our previous NMR-spectroscopic studies indicated pre-formation of long-range tertiary contacts in the ligand-free state of its aptamer domain. Loss of the structural pre-organization in a mutant of this RNA (G37A/C61U) resulted in the requirement of Mg2+ for ligand binding. Here, we investigate structural and stability aspects of the wild-type aptamer domain (Gsw) and the G37A/C61U-mutant (Gswloop) of the guanine-sensing riboswitch and their Mg2+-induced folding characteristics to dissect the role of long-range tertiary interactions, the link between pre-formation of structural elements and ligand-binding properties and the functional stability. Destabilization of the long-range interactions as a result of the introduced mutations for Gswloop or the increase in temperature for both Gsw and Gswloop involves pronounced alterations of the conformational ensemble characteristics of the ligand-free state of the riboswitch. The increased flexibility of the conformational ensemble can, however, be compensated by Mg2+. We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding

Mining regulatory 5′UTRs from cDNA deep sequencing datasets

Regulatory 5′ untranslated regions (r5′UTRs) of mRNAs such as riboswitches modulate the expression of genes involved in varied biological processes in both bacteria and eukaryotes. New high-throughput sequencing technologies could provide powerful tools for discovery of novel r5′UTRs, but the size and complexity of the datasets generated by these technologies makes it difficult to differentiate r5′UTRs from the multitude of other types of RNAs detected. Here, we developed and implemented a bioinformatic approach to identify putative r5′UTRs from within large datasets of RNAs recently identified by pyrosequencing of the Vibrio cholerae small transcriptome. This screen yielded only ∼1% of all non-overlapping RNAs along with 75% of previously annotated r5′UTRs and 69 candidate V. cholerae r5′UTRs. These candidates include several putative functional homologues of diverse r5′UTRs characterized in other species as well as numerous candidates upstream of genes involved in pathways not known to be regulated by r5′UTRs, such as fatty acid oxidation and peptidoglycan catabolism. Two of these novel r5′UTRs were experimentally validated using a GFP reporter-based approach. Our findings suggest that the number and diversity of pathways regulated by r5′UTRs has been underestimated and that deep sequencing-based transcriptomics will be extremely valuable in the search for novel r5′UTRs