Magnetorquer Based Attitude Control for a Nanosatellite Testplatform

This paper presents the design of an attitude controller for a magnetically actuated nanosatellite. The goal of this attitude control system is to be able to dump excess kinetic rotational energy as well as to point to a rotating frame with an accuracy of five degrees on each axis. From the options considered, a locally asymptotically stable PD type controller is chosen as the best solution to the local attitude control pointing problem. This design choice is verified via simulation which includes actuator constraints, environmental disturbance torques due to drag, solar radiation, residual dipoles and gravity, and satellite models from the cubesat Delfi-n3Xt.Delft University of Technolog

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

In cancer, the tumour suppressor gene TP53 undergoes frequent missense mutations that endow mutant p53 proteins with oncogenic properties. Until now, a universal mutant p53 gain-of-function program has not been defined. By means of multi-omics: proteome, DNA interactome (chromatin immunoprecipitation followed by sequencing) and transcriptome (RNA sequencing/microarray) analyses, we identified the proteasome machinery as a common target of p53 missense mutants. The mutant p53-proteasome axis globally affects protein homeostasis, inhibiting multiple tumour-suppressive pathways, including the anti-oncogenic KSRP-microRNA pathway. In cancer cells, p53 missense mutants cooperate with Nrf2 (NFE2L2) to activate proteasome gene transcription, resulting in resistance to the proteasome inhibitor carfilzomib. Combining the mutant p53-inactivating agent APR-246 (PRIMA-1MET) with the proteasome inhibitor carfilzomib is effective in overcoming chemoresistance in triple-negative breast cancer cells, creating a therapeutic opportunity for treatment of solid tumours and metastasis with mutant p53