24 research outputs found

    Solid foundations? Towards a historical sociology of prison building programmes in England and Wales, 1959–2015

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    Between 1959 and 2015 the UK government embarked upon five major phases of prison building in England and Wales. Drawing upon detailed archival research, this article offers a historical sociology of prison building programmes. It traces the evolution of prison building as a public policy concern and documents how this key site of penal policymaking was interpreted, and contested, by policy actors who were themselves embedded within deep institutional structures of power and meaning. It argues that prison building has moved from the margins to the mainstream of penal policy, shaped by strongly-held convictions about the liberal-democratic state, the competition for control of finite resources and the complex ?geography of administration? that underpins the British machinery of government

    Ideologies and crime:Political ideas and the dynamics of crime control

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    This paper assembles some theoretical resources for a project that investigates the ways in which thinking about politics has since the 1970s been bound up with thinking and action around crime. Such investigation is hampered by a dominant (neo-liberal) narrative of governance that tends to reduce crime policy to a ‘contest’ between tactics and technique. In contrast, we establish a political framework for theorizing crime and its control. This framework calls for close interpretive analysis of the ways in which disputes about the crime question are always in part contests between different political ideologies and the meaning and significance of their defining concepts. By revisiting penal developments of recent several decades with these questions in mind, one can get closer to the heart of what is at stake when crime is being discussed and acquire a better sense of why crime and its control are legitimately the subject of politics

    The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

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    ABSTRACT Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering of synaptogenesis transduction pathways via glutamatergic mechanisms. Preclinical data suggest that blockade of metabotropic glutamate (mGlu2/3) receptors shares many overlapping features and mechanisms with ketamine and may also provide rapid efficacy for TRD patients. Central dopamine circuitry is recognized as an end target for mood regulation and hedonic valuation and yet has been largely neglected in mechanistic studies of antidepressant-relevant effects of ketamine. Herein, we evaluated the changes in dopaminergic neurotransmission after acute administration of ketamine and the mGlu2/3 receptor antagonist LY341495 [(2S)-2-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid ] in preclinical models using electrophysiologic, neurochemical, and behavioral endpoints. When given acutely, both ketamine and LY341495, but not the selective serotonin reuptake inhibitor (SSRI) citalopram, increased the number of spontaneously active dopamine neurons in the ventral tegmental area (VTA), increased extracellular levels of dopamine in the nucleus accumbens and prefrontal cortex, and enhanced the locomotor stimulatory effects of the dopamine D 2/3 receptor agonist quinpirole. Further, both ketamine and LY341495 reduced immobility time in the tail-suspension assay in CD1 mice, which are relatively resistant to SSRI antidepressants. Both the VTA neuronal activation and the antidepressant phenotype induced by ketamine and LY341495 were attenuated by the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-(9CI)-benzo[f]quinoxaline-7-sulfonamide, indicating AMPA-dependent effects. These findings provide another overlapping mechanism of action of ketamine and mGlu2/3 receptor antagonism that differentiates them from conventional antidepressants and thus support the potential rapidly acting antidepressant actions of mGlu2/3 receptor antagonism in patients
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