14 research outputs found
Hypolipidemic and Anti-Obesity Effects of Hydroalcoholic Extract of Brazilian Red Propolis in a Rodent Model of Dyslipidemia
The widespread use of Brazilian red propolis extract promotes an increased
production rate in the Northeast region of Brazil, with an impressive
economic turnover for the region. The rational use of the hydroalcoholic
extract of red propolis (HERP) raises the question about its value against
obesity. In this work, the aim is to evaluate the anti-obesity effect of HERP in
rats submitted to hyperlipid dietary (HLD) supplementation. HERP extraction
yield is 17.46% (m/v). The major chemical components of HERP are found to
be daidzein (4.16 ± 0.22 mg gâ1), formononetin (9.21 ± 0.10 mg gâ1), and
biochanin A (7.08 ± 0.09 mg gâ1). After 8 weeks, the animals under HLD
supplementation show significantly greater body weight gain, while after the
subsequent 4-week treatment with HERP, HLDâHERP animal shows lower
body weight gain than HLD-vehicle animals. Oral administration of HERP
also attenuates the pathological changes in the liver, kidney, and large
intestine caused by HLD supplementation. This study demonstrates that
HERP treatment has a hypolipidemic effect in a rodent model of dyslipidemia
and that HERP minimizes the impact of a hyperlipidic diet on murine body
weight parameters and abdominal fat accumulation.
Practical Applications: Brazilian red propolis is being exploited for a range of
biomedical applications. It is demonstrated that its extract has hypolipidemic
effect in a rodent model of dyslipidemia and minimizes the impact of a
hyperlipidic diet on murine body weight parameters and abdominal fat accumulation