Includes abstract.Includes bibliographical references (leaves 47-52).The aim of this study was to investigate the exposure-response relationship between the concentration of inhalable manganese dust and subclinical nervous system outcomes amongst workers in a South African manganese smelter with a view to identifying any exposure threshold below which adverse effects do not occur

Williams, Haidee Maxine

Cape Town University OpenUCT

A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: manganism symptoms and T1 hyperintense changes in the basal ganglia.

Agency for Toxic Substances and Disease Registry. Draft toxicological profile for manganese.

An investigation into the neurologic and neurobehavioral effects of long-term agrichemical use among deciduous fruit farm workers in the Western Cape, South Africa. Environmental Research

Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust.

Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity. Neurology 2006;67(11):1984-1989.

Cognitive function in a cohort of Danish steel workers. Neurotoxicology

Comparisons of methods for multiple hypothesis testing in neuropsychological research. Neuropsychology

Complications of parenteral nutrition.

Early manifestations of manganese neurotoxicity in humans: an update.

Environment and Health, Institute for Occupational Medicine. Occupational exposure limits:Criteria document for manganese and inorganic manganese compounds (Web Report

Estimating the prevalence of clinical manganism from a cascaded screening process in a South African ferro-manganese smelter. 2008; Available at: http://www.collegiumramazzini.org/download/MYERS08.pdf. Accessed January/11,

Evaluating and interpreting exposure-response relationships for manganese and neurobehavioral outcomes.

High signal intensity on magnetic resonance imaging as a predictor of neurobehavioral performance of workers exposed to manganese.

In: WHO Regional Office

Integrated risk information system database. : US Environmental Protection Agency;

Introduction to the chemical substances TLV.

Irreversible motor impairment in young addicts--ephedrone, manganism or both? Acta Neurol.Scand.

Labour. Hazardous Chemical Substances Regulations.

Lead neurotoxicity and socioeconomic status: Conceptual and analytical issues.

Liver transplantation in a patient with rapid onset parkinsonism-dementia complex induced by manganism secondary to liver failure. Arq.Neuropsiquiatr.

Long-term progression in chronic manganism: ten years of follow-up. Neurology

Manganese air exposure assessment and biological monitoring in the manganese alloy production industry.

Manganese and chronic hepatic encephalopathy. Lancet

Manganese and idiopathic parkinsonism:Similarities and differences. Neurology 1994;44:1583-1586.

Manganese exposure, essentiality & toxicity.

Manganese mineral commodity summary.

Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests.

Manganese neurotoxicity, a continuum of dysfunction: results from a community based study.

Manganese transport in eukaryotes: The role of DMT1. Neurotoxicology 2008;29:569-576.

Manganese-induced parkinsonism and Parkinson's disease.

Manganeseinduced Parkinsonism associated with methcathinone (Ephedrone) abuse. Arch.Neurol.

Manganic encephalopathy due to &quot;ephedrone&quot; abuse. Mov.Disord.

Manual for the Luria Nebraska neuropsychological battery.

Measuring effects of exposure. In:

Multiple significance tests: the Bonferroni method.

Neuroimaging in manganism. NeuroToxicology

Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity.

Neurological effects in workers exposed to manganese.

Neuromotor function in a cohort of Danish steel workers. Neurotoxicology

Neuropsychological correlates of manganese exposure: A meta-analysis.

Neuropsychological function in manganese alloy plant workers.

Occupational exposure samplng strategy manual.

Olfactory transport: a direct route of delivery of inhaled manganese phosphate to the rat brain. J.Tox.Environ.Health Part A

On the effect of black oxide of manganese when inhaled into the lungs.

On the health effects of solvents. In:

Organization. Concise international chemical assessment document: Manganese and its compounds.

Organization. Operational Guide for the WHO neurobehavioural core test battery.

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure.

Robust locally weighted regression and smoothing scatterplots.

Searching for a relationship between manganese and welding and Parkinson's disease.

Socioeconomic status in health research: one size does not fit all. JAMA

Speciation of manganese in cells and mitochondria: A search for the proximal cause of manganese neurotoxicity.

SPES: a psychological test system to diagnose environmental hazards.

Standardisation of a neuromotor test battery: the CATSYS system.

Stata 10. USA: Stata Corporation

Studies to determine the impact and implications of new occupational aerosol standards.

Substances Data Bank: Manganese and compounds.

Table Z-1 Limits for air contaminants. 2006; Available at: http://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STAND ARDS&p_id=9992. Accessed

The nervous system effects of occupational exposure on workers in a South African manganese smelter. Neurotoxicology

The nervous system effects of occupational exposure to manganese--measured as respirable dust--in a South African manganese smelter. Neurotoxicology

The transport of manganese across the blood-brain barrier.

The utility of biological monitoring for manganese in ferroalloy smelter workers in South Africa.

Threshold limit values for chemical substances and physical agents and biological exposure indices.

Toxic hazards of mining and smelting. In:

Tremor 3.0, User's manual. Snekkersten,

Using frequency domain characteristics to discriminate physiological and parkinsononian tremors.

Using psychological tests forthe early detection of neurotoxic effects of low level manganese exposure.

Examining evidence for a protective occupational exposure limit for inhalable manganese dust below which there are no adverse subclinical nervous system effects