709 research outputs found

    A pilot study of basal ganglia and thalamus structure by high dimensional mapping in children with Tourette syndrome

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    Background: Prior brain imaging and autopsy studies have suggested that structural abnormalities of the basal ganglia (BG) nuclei may be present in Tourette Syndrome (TS). These studies have focused mainly on the volume differences of the BG structures and not their anatomical shapes.  Shape differences of various brain structures have been demonstrated in other neuropsychiatric disorders using large-deformation, high dimensional brain mapping (HDBM-LD).  A previous study of a small sample of adult TS patients demonstrated the validity of the method, but did not find significant differences compared to controls. Since TS usually begins in childhood and adult studies may show structure differences due to adaptations, we hypothesized that differences in BG and thalamus structure geometry and volume due to etiological changes in TS might be better characterized in children. Objective: Pilot the HDBM-LD method in children and estimate effect sizes. Methods: In this pilot study, T1-weighted MRIs were collected in 13 children with TS and 16 healthy, tic-free, control children. The groups were well matched for age.  The primary outcome measures were the first 10 eigenvectors which are derived using HDBM-LD methods and represent the majority of the geometric shape of each structure, and the volumes of each structure adjusted for whole brain volume. We also compared hemispheric right/left asymmetry and estimated effect sizes for both volume and shape differences between groups. Results: We found no statistically significant differences between the TS subjects and controls in volume, shape, or right/left asymmetry.  Effect sizes were greater for shape analysis than for volume. Conclusion: This study represents one of the first efforts to study the shape as opposed to the volume of the BG in TS, but power was limited by sample size. Shape analysis by the HDBM-LD method may prove more sensitive to group differences

    Millimeter dust continuum emission unveiling the true mass of giant molecular clouds in the Small Magellanic Cloud

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    CO observations have been so far the best way to trace molecular gas in external galaxies, but at low metallicity the gas mass deduced could be largely underestimated. At present, the kinematic information of CO data cubes are used to estimate virial masses and trace the total mass of the molecular clouds. Millimeter dust emission can also be used as a dense gas tracer and could unveil H2 envelopes lacking CO. These different tracers must be compared in different environments. This study compares virial masses to masses deduced from millimeter emission, in two GMC samples: the local molecular clouds in our Galaxy and their equivalents in the Small Magellanic Cloud (SMC), one of the nearest low metallicity dwarf galaxy. In our Galaxy, mass estimates deduced from millimeter emission are consistent with masses deduced from gamma ray analysis and trace the total mass of the clouds. Virial masses are systematically larger (twice on average) than mass estimates from millimeter dust emission. This difference decreases toward high masses and has already been reported in previous studies. In the SMC however, molecular cloud masses deduced from SIMBA millimeter observations are systematically higher (twice on average for conservative values of the dust to gas ratio and dust emissivity) than the virial masses from SEST CO observations. The observed excess can not be accounted for by any plausible change of dust properties. Taking a general form for the virial theorem, we show that a magnetic field strength of ~15 micro Gauss in SMC clouds could provide additional support to the clouds and explain the difference observed. Masses of SMC molecular clouds have therefore been underestimated so far. Magnetic pressure may contribute significantly to their support.Comment: 10 pages, 2 figures, Astronomy & Astrophysics accepte

    Search for associated Higgs boson production using like charge dilepton events in p(p)over-bar collisions at root s=1.96 TeV

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    We present a search for associated Higgs boson production in the process p (p) over bar -> W/ZH -> l(+/-)l'(+/-) + X in ee, e mu, and mu mu final states. The search is based on data collected by the D0 experiment at the Fermilab Tevatron Collider at root s = 1.96 TeV corresponding to 5.3 fb(-1) of integrated luminosity. We require two isolated leptons (electrons or muons) with the same electric charge and additional kinematic requirements. No significant excess above background is observed, and we set 95% C. L. observed (expected) upper limits on ratio of the production cross section to the standard model prediction of 6.4 (7.3) for a Higgs boson mass of 165 GeV and 13.5 (19.8) for a mass of 115 GeV

    Search for Large extra spatial dimensions in the dielectron and diphoton channels in ppˉ\bm{p\bar{p}} collisions at s=\bm{\sqrt{s}=}1.96 TeV

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    We report on a search for large extra spatial dimensions in the dielectron and diphoton channels using a data sample of 1.05 \invfb of \ppb collisions at a center-of-mass energy of 1.96 TeV collected by the D0 detector at the Fermilab Tevatron Collider. The invariant mass spectrum of the data agrees well with the prediction of the standard model. We find 95% C.L. lower limits on the effective Planck scale between 2.1 and 1.3 TeV for 2 to 7 extra dimensions.Comment: 7 pages, 3 figures, 3 tables, submitted to Phys. Rev. Let

    Search for charged massive long-lived particles with the D0 detector

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    We search for charged massive long-lived particles using 1.1 fb1^{-1} of data collected by the D0 detector at the Fermilab Tevatron ppˉp\bar{p} Collider. Time-of-flight information is used to search for pair produced long-lived tau sleptons, gaugino-like charginos, and higgsino-like charginos. We find no evidence of a signal and set 95% C.L. cross section upper limits for staus, which vary from 0.31pb to 0.04pb for stau masses between 60 GeV and 300 GeV. We also set lower mass limits of 206 GeV (171 GeV) for pair produced charged gauginos (higgsinos).Comment: To be submitted to Phys. Rev. Letters, V2: updated the figures and references, V3: final version submitted to PRL and changes in title and abstracts from "stable" to "long-lived

    Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV

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    We present cross section measurements for Z/gamma*+jets+X production, differential in the transverse momenta of the three leading jets. The data sample was collected with the D0 detector at the Fermilab Tevatron proton anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to an integrated luminosity of 1 fb-1. Leading and next-to-leading order perturbative QCD predictions are compared with the measurements, and agreement is found within the theoretical and experimental uncertainties. We also make comparisons with the predictions of four event generators. Two parton-shower-based generators show significant shape and normalization differences with respect to the data. In contrast, two generators combining tree-level matrix elements with a parton shower give a reasonable description of the the shapes observed in data, but the predicted normalizations show significant differences with respect to the data, reflecting large scale uncertainties. For specific choices of scales, the normalizations for either generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure

    Observation of ZZ production in ppbar collisions at sqrt(s) = 1.96 TeV

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    We present an observation for ZZ -> l+l-l'+l'- (l, l' = e or mu) production in ppbar collisions at a center-of-mass energy of sqrt(s) = 1.96 TeV. Using 1.7 fb-1 of data collected by the D0 experiment at the Fermilab Tevatron Collider, we observe three candidate events with an expected background of 0.14 +0.03 -0.02 events. The significance of this observation is 5.3 standard deviations. The combination of D0 results in this channel, as well as in ZZ -> l+l-nunubar, yields a significance of 5.7 standard deviations and a combined cross section of sigma(ZZ) = 1.60 +/- 0.63 (stat.) +0.16 -0.17 (syst.) pb.Comment: 7 pages, 1 figure, 2 tables Modified slightly following review proces

    A search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology at sqrt(s) = 1.96 TeV

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    We report a search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology, using an integrated luminosity of 0.93 inverse femtobarn recorded by the D0 detector at the Fermilab Tevatron Collider. The analysis includes signal contributions from pp->ZH->nu nu b b, as well as from WH production in which the charged lepton from the W boson decay is undetected. Neural networks are used to separate signal from background. In the absence of a signal, we set limits on the cross section of pp->VH times the branching ratio of H->bb at the 95% C.L. of 2.6 - 2.3 pb, for Higgs boson masses in the range 105 - 135 GeV, where V=W,Z. The corresponding expected limits range from 2.8 pb - 2.0 pb.Comment: Submitted to Phys. Rev. Letter
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