Validation of a novel scoring system for changes in skeletal manifestations of hypophosphatasia in newborns, infants, and children: The Radiographic Global Impression of Change scale

Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. Although HPP during growth often manifests with distinctive radiographic skeletal features, no validated method was available to quantify them, including changes over time. We created the Radiographic Global Impression of Change (RGI-C) scale to assess changes in the skeletal burden of pediatric HPP. Site-specific pairs of radiographs of newborns, infants, and children with HPP from three clinical studies of asfotase alfa, an enzyme replacement therapy for HPP, were obtained at baseline and during treatment. Each pair was scored by three pediatric radiologists ( raters ), with nine raters across the three studies. Intrarater and interrater agreement was determined by weighted Kappa coefficients. Interrater reliability was assessed using intraclass correlation coefficients (ICCs) and by two-way random effects analysis of variance (ANOVA) and a mixed-model repeated measures ANOVA. Pearson correlation coefficients evaluated relationships of the RGI-C to the Rickets Severity Scale (RSS), Pediatric Outcomes Data Collection Instrument Global Function Parent Normative Score, Childhood Health Assessment Questionnaire Disability Index, 6-Minute Walk Test percent predicted, and Z-score for height in patients aged 6 to 12 years at baseline. Eighty-nine percent (8/9) of raters showed substantial or almost perfect intrarater agreement of sequential RGI-C scores (weighted Kappa coefficients, 0.72 to 0.93) and moderate or substantial interrater agreement (weighted Kappa coefficients, 0.53 to 0.71) in patients aged 0 to 12 years at baseline. Moderate-to-good interrater reliability was observed (ICC, 0.57 to 0.65). RGI-C scores were significantly (p ≤ 0.0065) correlated with the RSS and with measures of global function, disability, endurance, and growth in the patients aged 6 to 12 years at baseline. Thus, the RGI-C is valid and reliable for detecting clinically important changes in skeletal manifestations of severe HPP in newborns, infants, and children, including during asfotase alfa treatment. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc

Choosing Parameter Sets for NTRUEncrypt with NAEP and SVES-3

We present, for the first time, an algorithm to choose parameter sets for NTRUEncrypt that give a desired level of security. Note: This is an expanded version of a paper presented at CT-RSA 2005

A signature scheme from the finite field isomorphism problem

In a recent paper the authors and their collaborators proposed a new hard problem, called the finite field isomorphism problem, and they used it to construct a fully homomorphic encryption scheme. In this paper, we investigate how one might build a digital signature scheme from this new problem. Intuitively, the hidden field isomorphism allows us to convert short vectors in the underlying lattice of one field into generic looking vectors in an isomorphic field

Modified Parameter Attacks: Practical Attacks against CCA2 Secure Cryptosystems and Countermeasures

We introduce the concept of Modified Parameter Attacks, a natural extension of the idea of Adapative Chosen Ciphertext Attacks (CCA2) under which some CCA2 secure systems can be shown to be insecure. These insecurities can be addressed at the application level, but can also be addressed when cryptographic schemes are being designed. We survey some existing CCA2 secure systems which are vulnerable to this attack and suggest practical countermeasures

3. Launching the New Enterprise

As the academic year of 1945-46 approached, the intensity of activity in preparation for actually opening the school in the fall term became overwhelming. Incredible though it may seem, Ives and Day were able in a period of a few weeks to assemble the nucleus of a faculty, several of whom formed a continuing source of counsel and advice both during the school’s formative years and thereafter. Includes: The First Dean and the School’s Dedication; A Participant’s View of the Early Years; Ives Moves On; Several Views of Martin P. Catherwood; The Founders

Transcript secure signatures based on modular lattices

We introduce a class of lattice-based digital signature schemes based on modular properties of the coordinates of lattice vectors. We also suggest a method of making such schemes transcript secure via a rejection sampling technique of Lyubashevsky (2009). A particular instantiation of this approach is given, using NTRU lattices. Although the scheme is not supported by a formal security reduction, we present arguments for its security and derive concrete parameters (first version) based on the performance of state-of-the-art lattice reduction and enumeration tech- niques. In the revision, we re-evaluate the security of first version of the parameter sets, under the hybrid approach of lattice reduction attack the meet-in-the-middle attack. We present new sets of parameters that are robust against this attack, as well as all previous known attacks

Choosing Parameters for NTRUEncrypt

We describe a methods for generating parameter sets and calculating security estimates for NTRUEncrypt. Analyses are provided for the standardized product-form parameter sets from IEEE 1363.1-2008 and for the NTRU Challenge parameter sets

DA-Encrypt: Homomorphic Encryption via Non-Archimedean Diophantine Approximation --- Preliminary Report

We give a theoretical description of a new homomorphic encryption scheme DA-Encrypt that is based on (non-archimedean) Diophantine Approximation

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

Cytoplasmic dynein functions at several sites during mitosis; however, the basis of targeting to each site remains unclear. Tandem mass spectrometry analysis of mitotic dynein revealed a phosphorylation site in the dynein intermediate chains (ICs) that mediates binding to kinetochores. IC phosphorylation directs binding to zw10 rather than dynactin, and this interaction is needed for kinetochore dynein localization. Phosphodynein associates with kinetochores from nuclear envelope breakdown to metaphase, but bioriented microtubule (MT) attachment and chromosome alignment induce IC dephosphorylation. IC dephosphorylation stimulates binding to dynactin and poleward streaming. MT depolymerization, release of kinetochore tension, and a PP1-γ mutant each inhibited IC dephosphorylation, leading to the retention of phosphodynein at kinetochores and reduced poleward streaming. The depletion of kinetochore dynactin by moderate levels of p50(dynamitin) expression disrupted the ability of dynein to remove checkpoint proteins by streaming at metaphase but not other aspects of kinetochore dynein activity. Together, these results suggest a new model for localization of kinetochore dynein and the contribution of kinetochore dynactin