Categorizing US State Drinking Practices and Consumption Trends

US state alcohol consumption patterns and trends are examined in order to identify groups of states with similar drinking habits or cultures. Rates of heavy drinking and current abstention and per capita apparent consumption levels are used to categorize states. Six state groupings were identified: North Central and New England with the highest consumption and heavy drinking levels; Middle Atlantic, Pacific and South Coast with moderate drinking levels; and Dry South with the lowest drinking levels. Analyses of relationships between beer and spirits series for states within groups as compared to those in different groups failed to clearly indicate group cohesiveness

Letters between A. C. Nelson and William Kerr

Letters concerning a position in the art department at Utah Agricultural College

Correspondence between C. Larson, William Kerr, and C. F. Curtiss

Correspondence concerning a position as dairyman at Utah Agricultural College, including a statement on a book Mr. Larson published titled Principles and Practice of Buttermaking

Postal card from C. S. Tingey, as well as a letter from W. J. Kerr

Postal card and letter concerning a state warrant

Letters between A. C. Nelson and W. J. Kerr

Letters concerning a meeting for the State Board of Education

Ethnic Innovation and U.S. Multinational Firm Activity

This paper studies the impact that immigrant innovators have on the global activities of U.S. firms by analyzing detailed data on patent applications and on the operations of the foreign affiliates of U.S. multinational firms. The results indicate that increases in the share of a firm's innovation performed by inventors of a particular ethnicity are associated with increases in the share of that firm's affiliate activity in their native countries. Ethnic innovators also appear to facilitate the disintegration of innovative activity across borders and to allow U.S. multinationals to form new affiliates abroad without the support of local joint venture partners. Thus, this paper points out that immigration can enhance the competitiveness of multinational firms.

IL-21 receptor expression in human tendinopathy

The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward and early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly up regulated by proinflammatory cytokines (TNFα/IL-1β) in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells

BACKGROUND: Thrombopoietin (TPO), the primary cytokine regulating megakaryocyte proliferation and differentiation, exerts significant influence on other hematopoietic lineages as well, including erythroid, granulocytic and lymphoid lineages. We previously demonstrated that the receptor for TPO, c-mpl, is expressed by a subset of human adult bone marrow hematopoietic stem/progenitor cells (HSC/PC) that are enriched for long-term multilineage repopulating ability in the SCID-hu Bone in vivo model of human hematopoiesis. METHODS: Here, we employ flow cytometry and an anti-c-mpl monoclonal antibody to comprehensively define the surface expression pattern of c-mpl in four differentiation stages of human CD34(+ )HSC/PC (I: CD34(+)38(--), II: CD34(+)38(dim), III: CD34(+)38(+), IV: CD34(dim)38(+)) for the major sources of human HSC: fetal liver (FL), umbilical cord blood (UCB), adult bone marrow (ABM), and cytokine-mobilized peripheral blood stem cells (mPBSC). We use a surrogate in vivo model of human thymopoiesis, SCID-hu Thy/Liv, to compare the capacity of c-mpl(+ )vs. c-mpl(-- )CD34(+)38(--/dim )HSC/PC for thymocyte reconstitution. RESULTS: For all tissue sources, the percentage of c-mpl(+ )cells was significantly highest in stage I HSC/PC (FL 72 ± 10%, UCB 67 ± 19%, ABM 82 ± 16%, mPBSC 71 ± 15%), and decreased significantly through stages II, III, and IV ((FL 3 ± 3%, UCB 8 ± 13%, ABM 0.6 ± 0.6%, mPBSC 0.2 ± 0.1%) [ANOVA: P < 0.0001]. The relative median fluorescence intensity of c-mpl expression was similarly highest in stage I, decreasing through stage IV [ANOVA: P < 0.0001]. No significant differences between tissue sources were observed for either % c-mpl(+ )cells [P = 0.89] or intensity of c-mpl expression [P = 0.21]. Primary Thy/Liv grafts injected with CD34(+)38(--/dim)c-mpl(+ )cells showed slightly higher levels of donor HLA(+ )thymocyte reconstitution vs. CD34(+)38(--/dim)c-mpl(--)-injected grafts and non-injected controls (c-mpl(+ )vs. c-mpl(--): CD2(+ )6.8 ± 4.5% vs. 2.8 ± 3.3%, CD4(+)8(-- )54 ± 35% vs. 31 ± 29%, CD4(--)8(+ )29 ± 19% vs. 18 ± 14%). CONCLUSION: These findings support the hypothesis that the TPO receptor, c-mpl, participates in the regulation of primitive human HSC from mid-fetal through adult life. This study extends our previous work documenting human B-lineage, myeloid and CD34(+ )cell repopulation by c-mpl(+ )progenitors to show that c-mpl(+ )HSC/PC are also capable of significant T-lineage reconstitution in vivo. These results suggest that c-mpl merits consideration as a selective surface marker for the identification and isolation of human HSC in both basic research and clinical settings

A large local rotational speed for the Galaxy found from proper-motions: Implications for the mass of the Milky-Way

Predictions from a Galactic Structure and Kinematic model are compared to the absolute proper-motions of about 30,000 randomly selected stars with $9 < B_{\rm J} \le 19$ derived from the Southern Proper-Motion Program (SPM) toward the South Galactic Pole. The absolute nature of the SPM proper-motions allow us to measure not only the relative motion of the Sun with respect to the local disk, but also, and most importantly, the overall state of rotation of the local disk with respect to galaxies. The SPM data are best fit by models having a solar peculiar motion of +5 km~s$^{-1}$ in the V-component (pointing in the direction of Galactic rotation), a large LSR speed of 270 km~s$^{-1}$, and a disk velocity ellipsoid that points towards the Galactic center. We stress, however, that these results rest crucially on the assumptions of both axisymmetry and equilibrium dynamics. The absolute proper-motions in the U-component indicate a solar peculiar motion of $11.0 \pm 1.5$ km~s$^{-1}$, with no need for a local expansion or contraction term. The implications of the large LSR speed are discussed in terms of gravitational mass of the Galaxy inferred from the most recent and accurate determination for the proper-motion of the LMC. We find that our derived value for the LSR is consistent both with the mass of the Galaxy inferred from the motion of the Clouds ($3 - 4 \times 10^{12} M_\odot$ to $\sim 50$ kpc), as well as the timing argument, based on the binary motion of M31 and the Milky Way, and Leo I and the Milky Way ($\ge 1.2 \times 10^{12} M_\odot$ to $\sim 200$ kpc).Comment: 7 pages (AAS Latex macro v4.0), 2 B&W postscript figures, accepted for publication on ApJ, Letters sectio