Producing an Input Price Index

This paper is designed to address the need--and especially the feasibility--of producing what is referred to as an input price index, at the U.S. Bureau of Labor Statistics (BLS).ii The current interest in this set of proposed price indexes arose over concerns that the BLS does not directl

The Trans-Heliospheric Survey

CONTEXT: Though the solar wind is characterized by spatial and temporal variability across a wide range of scales, long-term averages of in situ measurements have revealed clear radial trends: changes in average values of basic plasma parameters (e.g., density, temperature, and speed) and a magnetic field with a distance from the Sun. AIMS: To establish our current understanding of the solar wind's average expansion through the heliosphere, data from multiple spacecraft needed to be combined and standardized into a single dataset. METHODS: In this study, data from twelve heliospheric and planetary spacecraft - Parker Solar Probe (PSP), Helios 1 and 2, Mariner 2 and 10, Ulysses, Cassini, Pioneer 10 and 11, New Horizons, and Voyager 1 and 2 - were compiled into a dataset spanning over three orders of magnitude in heliocentric distance. To avoid introducing artifacts into this composite dataset, special attention was given to the solar cycle, spacecraft heliocentric elevation, and instrument calibration. RESULTS: The radial trend in each parameter was found to be generally well described by a power-law fit, though up to two break points were identified in each fit. CONCLUSIONS: These radial trends are publicly released here to benefit research groups in the validation of global heliospheric simulations and in the development of new deep-space missions such as Interstellar Probe

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization in vitro and are commercially available; thus are commonly used to evaluate efficacy of bio-conjugates for in vivo delivery. In contrast, most clinically-advanced non-formulated compounds, using conjugation as a delivery strategy, are fully chemically modified (100% of nucleotides). Here, we compare partially and fully chemically modified siRNAs in conjugate mediated delivery. We show that fully modified siRNAs are retained at 100x greater levels in various tissues, independently of the nature of the conjugate or siRNA sequence, and support productive mRNA silencing. Thus, fully chemically stabilized siRNAs may provide a better platform to identify novel moieties (peptides, aptamers, small molecules) for targeted RNAi delivery