The Osteology and Relationships of Certain Gobioid Fishes, with Particular Reference to the Genera Kraemeria and Microdesmus

there is a group of elongate, presumably bur-rowing forms of small to medium size that superficially resemble one another. Many o

A survey of upper jaw musculature in higher teleostean fishes

http://deepblue.lib.umich.edu/bitstream/2027.42/57160/1/OP724.pd

Speciation In The Fishes Of The Genus Menidia

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137560/1/evo02748.pd

Variation and systematic significance of vertebral counts in the American fishes of the family Percidae

http://deepblue.lib.umich.edu/bitstream/2027.42/56337/1/MP093.pd

Movable head armature in higher teleostean fishes

A general pattern of movable head armature, composed of serrations on the borders of the lacrimal and preopercle and of a spine on the opercle, evolved among early acanthopterygians and is retained among many basal percoid families. In the more specialized higher teleostean groups this pattern is modified in various ways. Scorpaeniform fishes develop a suborbital stay with which the lacrimal is rigidly united. Elsewhere lacrimal serrations are generally absent, but in some bottom-resting forms preopercular or opercular armature becomes highly specialized. An association between head armature, fin spines, and changes in locomotion in the development of the acanthopterygian state of teleostean evolution is suggested.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42635/1/10641_2004_Article_BF00001612.pd

Function and structure in the paired fins of scorpaeniform fishes

The paired fins of the basic, ancestral type of free-swimming acanthopterygian teleost serve primarily in guiding the forward course of movement and in maneuvering within the water column. In various scorpaeniform fishes the paired fins have taken on a number of other functions associated with a bottom-living mode of life. Among these are: defense against predation, probing for food items, propping the forward part of the body away from the bottom, progressing over it, digging into it, and the development of a suction disc for attachment to it. The relationship between these developments and paired-fin structure is the subject of the paper.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42637/1/10641_2004_Article_BF00002508.pd

Modelling the air-gap field strength of electric machines to improve performance of haptic mechanisms

The air-gap of electro-magnetic (EM) actuators determines key operating parameters such as their ability to generate force. In haptic devices these parameters are not optimised for the conditions typically seen in operation and include the heat produced in the air-gap, the volume of the air-gap, and the intensity and direction of the magnetic field. The relationship between these parameters is complex thus design decisions are difficult to make. This paper considers the role of the radial magnetic field in cylindrical electric motors, a type often used in haptic devices. Two models are derived and compared with experimental measurements. The first model is a closed form solution, the second is a classic Poisson solution to Ampere's equation. These models are shown to be valid for making more general design decisions in relation to haptic actuators, and in particular allow an evaluation of the trade off between the volume of the air-gap, the resulting radial magnetic field and hence heat generated and the resulting forces

Living in the Past: Phylogeography and Population Histories of Indo-Pacific Wrasses (Genus Halichoeres) in Shallow Lagoons versus Outer Reef Slopes

Sea level fluctuations during glacial cycles affect the distribution of shallow marine biota, exposing the continental shelf on a global scale, and displacing coral reef habitat to steep slopes on oceanic islands. In these circumstances we expect that species inhabiting lagoons should show shallow genetic architecture relative to species inhabiting more stable outer reefs. Here we test this expectation on an ocean-basin scale with four wrasses (genus Halichoeres): H. claudia (N = 194, with ocean-wide distribution) and H. ornatissimus (N = 346, a Hawaiian endemic) inhabit seaward reef slopes, whereas H. trimaculatus (N = 239) and H. margaritaceus (N = 118) inhabit lagoons and shallow habitats throughout the Pacific. Two mitochondrial markers (cytochrome oxidase I and control region) were sequenced to resolve population structure and history of each species. Haplotype and nucleotide diversity were similar among all four species. The outer reef species showed significantly less population structure, consistent with longer pelagic larval durations. Mismatch distributions and significant negative Fu’s F values indicate Pleistocene population expansion for all species, and (contrary to expectations) shallower histories in the outer slope species. We conclude that lagoonal wrasses may persist through glacial habitat disruptions, but are restricted to refugia during lower sea level stands. In contrast, outer reef slope species have homogeneous and well-connected populations through their entire ranges regardless of sea level fluctuations. These findings contradict the hypothesis that shallow species are less genetically diverse as a consequence of glacial cycles

Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling

Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving our ability to study each of these stages individually, but do not capture the connections between them. Here we present an approach for building a network of physical links among these data that can be used to prioritize targets for pharmacological intervention. Our method recovers the critical missing links between proteomic and transcriptional data by relating changes in chromatin accessibility to changes in expression and then uses these links to connect proteomic and transcriptome data. We applied our approach to integrate epigenomic, phosphoproteomic and transcriptome changes induced by the variant III mutation of the epidermal growth factor receptor (EGFRvIII) in a cell line model of glioblastoma multiforme (GBM). To test the relevance of the network, we used small molecules to target highly connected nodes implicated by the network model that were not detected by the experimental data in isolation and we found that a large fraction of these agents alter cell viability. Among these are two compounds, ICG-001, targeting CREB binding protein (CREBBP), and PKF118–310, targeting β-catenin (CTNNB1), which have not been tested previously for effectiveness against GBM. At the level of transcriptional regulation, we used chromatin immunoprecipitation sequencing (ChIP-Seq) to experimentally determine the genome-wide binding locations of p300, a transcriptional co-regulator highly connected in the network. Analysis of p300 target genes suggested its role in tumorigenesis. We propose that this general method, in which experimental measurements are used as constraints for building regulatory networks from the interactome while taking into account noise and missing data, should be applicable to a wide range of high-throughput datasets.National Science Foundation (U.S.) (DB1-0821391)National Institutes of Health (U.S.) (Grant U54-CA112967)National Institutes of Health (U.S.) (Grant R01-GM089903)National Institutes of Health (U.S.) (P30-ES002109

Comparable Ages for the Independent Origins of Electrogenesis in African and South American Weakly Electric Fishes

One of the most remarkable examples of convergent evolution among vertebrates is illustrated by the independent origins of an active electric sense in South American and African weakly electric fishes, the Gymnotiformes and Mormyroidea, respectively. These groups independently evolved similar complex systems for object localization and communication via the generation and reception of weak electric fields. While good estimates of divergence times are critical to understanding the temporal context for the evolution and diversification of these two groups, their respective ages have been difficult to estimate due to the absence of an informative fossil record, use of strict molecular clock models in previous studies, and/or incomplete taxonomic sampling. Here, we examine the timing of the origins of the Gymnotiformes and the Mormyroidea using complete mitogenome sequences and a parametric Bayesian method for divergence time reconstruction. Under two different fossil-based calibration methods, we estimated similar ages for the independent origins of the Mormyroidea and Gymnotiformes. Our absolute estimates for the origins of these groups either slightly postdate, or just predate, the final separation of Africa and South America by continental drift. The most recent common ancestor of the Mormyroidea and Gymnotiformes was found to be a non-electrogenic basal teleost living more than 85 millions years earlier. For both electric fish lineages, we also estimated similar intervals (16–19 or 22–26 million years, depending on calibration method) between the appearance of electroreception and the origin of myogenic electric organs, providing rough upper estimates for the time periods during which these complex electric organs evolved de novo from skeletal muscle precursors. The fact that the Gymnotiformes and Mormyroidea are of similar age enhances the comparative value of the weakly electric fish system for investigating pathways to evolutionary novelty, as well as the influences of key innovations in communication on the process of species radiation