Serum Glutamate Levels Correlate with Gleason Score and Glutamate Blockade Decreases Proliferation, Migration, and Invasion and Induces Apoptosis in Prostate Cancer Cells

During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer (PCa) or metastatic castrate-resistant PCa (mCRPCa) to establish clinical relevance. The effect of glutamate-deprivation or blockade by metabotropic glutamate receptor 1 (GRM1)-antagonists was investigated on PCa cells’ growth, migration, and invasion to establish biological relevance

stall-Mediated Extrinsic Control of Ovarian Follicle Formation in Drosophila

Complex patterns of morphogenesis require intricate coordination of multiple, regulatory processes that control cellular identities, shapes, and behaviors, both locally and over vast distances in the developing organism or tissue. Studying Drosophila oogenesis as a model for tissue morphogenesis, we have discovered extraovarian regulation of follicle formation. Clonal analysis and ovary transplantation have demonstrated that long-range control of follicle individualization requires stall gene function in cells outside of the ovary. Although tissue nonautonomous regulation has been shown to govern follicle maturation and survival, this is the first report of an extraovarian pathway involved in normal follicle formation

Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells

During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer (PCa) or metastatic castrate-resistant PCa (mCRPCa) to establish clinical relevance. The effect of glutamate-deprivation or blockade by metabotropic glutamate receptor 1 (GRM1)-antagonists was investigated on PCa cells’ growth, migration, and invasion to establish biological relevance

with the following sections:

This report is preliminary and has not been reviewed for conformity with U.S. Geological Survey editorial standards or with the North American Stratigraphic Code. Any use of trade, product or firm names is for descriptive purposes only and does not imply This report presents scanning electron microscope (SEM) photomicrographs of 64 species and genera of benthic foraminifers, diatoms, dinoflagellate cysts, ostracodes and pollen that represent the most common microfossil species preserved in sediments fro

Things fall apart? Discourses on agency and change in organizations

The history of the concept of ‘agency’ in organizational theory over the last 50 years makes dismal reading. From a position of unbounded optimism that organizational change could be managed as a rational or planned process with a transparent agenda, we now confront restructured workplaces characterized by new forms of flexibility, hypercomplexity and chaos in which the nature, sources and consequences of change interventions have become fundamentally problematic. How did this occur and what implications does it have for our understanding of agency and change in organizations? Should we assume that rationalist concepts of centred agency are no longer viable, or should we welcome the plural and promising new forms of decentred agency emerging within organizations? This article presents a selective interdisciplinary history of competing disciplinary discourses on agency and change in organizations, classified into rationalist, contextualist, dispersalist and constructionist discourses. Although the four discourses clarify the meta-theoretical terrain of agency in relation to organizational change theories, the growing plurality of discourses challenges the social scientific ambitions of the research field to be objective, cumulative or unified. It is concluded that the future for research on agency and change in organizations is characterized by new opportunities for empirical investigation and intervention, but also by mounting threats to the epistemological rationale of objective knowledge and the efficacy of practice