Developmental divergence: motor trajectories in children with fragile X syndrome with and without co-occurring autism.

BackgroundAutism spectrum disorder (ASD) is highly prevalent in fragile X syndrome (FXS), affecting 50-70% of males. Motor impairments are a shared feature across autism and FXS that may help to better characterize autism in FXS. As motor skills provide a critical foundation for various language, cognitive, and social outcomes, they may serve an important mechanistic role for autism in FXS. As such, this study aimed to identify differences in motor trajectories across direct assessment and parent-report measures of fine and gross motor development between FXS with and without autism, and typical development, while controlling for cognitive functioning.MethodsThis prospective longitudinal study included 42 children with FXS, 24 of whom also had ASD (FXS + ASD), as well as 40 typically developing children. The Mullen Scales of Early Learning provided a direct measure of fine and gross motor skills, and the Vineland Adaptive Behavior Scales provided a measure of parent-reported fine and gross motor skills. Random slopes and random intercepts multilevel models were tested to determine divergence in developmental motor trajectories between groups when controlling for cognitive level.ResultsModel results indicated the children with FXS + ASD diverged from TD children by 9-months on all measures of gross and fine motor skills, even when controlling for cognitive level. Results also indicated an early divergence in motor trajectories of fine and gross motor skills between the FXS + ASD and FXS groups when controlling for cognitive level. This divergence was statistically significant by 18 months, with the FXS + ASD showing decelerated growth in motor skills across direct observation and parent-report measures.ConclusionsThis study is the first to examine longitudinal trends in motor development in children with FXS with and without comorbid ASD using both direct assessment and parent-report measures of fine and gross motor. Furthermore, it is among the first to account for nonverbal cognitive delays, a step towards elucidating the isolated role of motor impairments in FXS with and without ASD. Findings underscore the role of motor impairments as a possible signal representing greater underlying genetic liability, or as a potential catalyst or consequence, of co-occurring autism in FXS

Usefulness and Usability of a Personal Health Record and Survivorship Care Plan for Colorectal Cancer Survivors: Survey Study

Background: As a result of improvements in cancer screening, treatment, and supportive care, nearly two-thirds of individuals diagnosed with colorectal cancer (CRC) live for 5 years after diagnosis. An ever-increasing population of CRC survivors creates a need for effective survivorship care to help manage and mitigate the impact of CRC and its treatment. Personal health records (PHRs) and survivorship care plans provide a means of supporting the long-term care of cancer survivors. Objective: The purpose of this study is to characterize the usefulness of a CRC PHR and survivorship care plan and to describe the usability of these technologies in a population of CRC survivors. To our knowledge, this is the first study to assess a PHR and survivorship care plan specifically targeting CRC survivors. Methods: Twenty-two patients with CRC were recruited from surgery clinics of an academic medical center and Veterans Affairs hospital in Indianapolis and provided access to an online Colorectal Cancer Survivor’s Personal Health Record (CRCS-PHR). Survey data were collected to characterize the usefulness of the CRCS-PHR and describe its usability in a population of CRC survivors. CRC survivors were surveyed 6 months after being provided online access. Means and proportions were used to describe the usefulness and ease of using the CRC website. Open-ended questions were qualitatively coded using the constant comparative method. Results: CRC survivors perceived features related to their health care (ie, summary of cancer treatment history, follow-up care schedule, description of side effects, and list of community resources) to be more useful than communication features (ie, creating online relationships with family members or caregivers, communicating with doctor, and secure messages). CRC survivors typically described utilizing traditional channels (eg, via telephone or in person) to communicate with their health care provider. Participants had overall positive perceptions with respect to ease of use and overall satisfaction. Major challenges experienced by participants included barriers to system log-in, lack of computer literacy or experience, and difficulty entering their patient information. Conclusions: For CRC, survivors may find the greater value in a PHR’s medical content than the communication functions, which they have available elsewhere. These findings regarding the usefulness and usability of a PHR for the management of CRC survivorship provide valuable insights into how best to tailor these technologies to patients’ needs. These findings can inform future design and development of PHRs for purposes of both cancer and chronic disease management

Interregional Analysis of Interstate Dairy Compacts

Livestock Production/Industries, Marketing,

A new approach to the pulsed thermocouple for high gas temperature measurements

Pulsed thermocouple systems can be used to measure gas temperatures above the melting point of the thermocouple by various techniques of short term of intermittent exposure of the thermocouple operating at lower temperatures. An approach is described which uses a thermocouple cooled by a small jet of inert gas. When a measurement is to be made, the cooling jet is turned off and the thermocouple allowed to heat up to near its melting point, at which time the cooling is reapplied. The final temperature which the thermocouple should have attained is then calculated by extrapolating an exponential curve fit to the data. Temperature measurements can be recorded and displayed in near real time by using modern high-speed computing systems to perform these calculations. Examples of the technique applied to high temperature jet engine combustor development are presented

Weak-field limit of Kaluza-Klein models with spherical compactification: experimental constraints

We investigate the classical gravitational tests for the six-dimensional Kaluza-Klein model with spherical (of a radius $a$) compactification of the internal space. The model contains also a bare multidimensional cosmological constant $\Lambda_6$. The matter, which corresponds to this ansatz, can be simulated by a perfect fluid with the vacuum equation of state in the external space and an arbitrary equation of state with the parameter $\omega_1$ in the internal space. For example, $\omega_1=1$ and $\omega_1=2$ correspond to the monopole two-forms and the Casimir effect, respectively. In the particular case $\Lambda_6=0$, the parameter $\omega_1$ is also absent: $\omega_1=0$. In the weak-field approximation, we perturb the background ansatz by a point-like mass. We demonstrate that in the case $\omega_1>0$ the perturbed metric coefficients have the Yukawa type corrections with respect to the usual Newtonian gravitational potential. The inverse square law experiments restrict the parameters of the model: $a/\sqrt{\omega_1}\lesssim 6\times10^{-3}\ {{cm}}$. Therefore, in the Solar system the parameterized post-Newtonian parameter$\gamma$is equal to 1 with very high accuracy. Thus, our model satisfies the gravitational experiments (the deflection of light and the time delay of radar echoes) at the same level of accuracy as General Relativity. We demonstrate also that our background matter provides the stable compactification of the internal space in the case$\omega_1>0$. However, if$\omega_1=0$, then the parameterized post-Newtonian parameter$\gamma=1/3$, which strongly contradicts the observations.Comment: 8 pages, no figures, revised version, equations and references added, accepted for publication in Phys. Rev. D. arXiv admin note: significant text overlap with arXiv:1107.338

An Overview of Animal Facilitated Therapy

An 81 year old woman sat in her wheelchair in front of a window at a nursing home surrounded by her family whom she no longer recognized. She had been in the home for two years, her mental and physical health steadily deteriorating. She spoke a language all her own, no longer could anyone decipher any English or Norwegian from it. The old woman plucked invisible entities from the air and placed them in her lap. The only glimmer of recognition or reality for her was aroused when she was asked about her cat, Munse. Grandma, how\u27s Munse? Where\u27s Munse, Grandma? The only understandable words she speaks: Munse? Here kitty. Meeow. She calls for her companion of eight years. A gray stuffed-toy cat is placed in her lap instead, she strokes it once or twice and then falls still and silent. What might it have meant to this elderly woman to have kept her companion with her? Could it have helped her hold on to reality longer, maintained her health and improved the general quality of her life

Testing Alternative Theories of Gravity using LISA

We investigate the possible bounds which could be placed on alternative theories of gravity using gravitational wave detection from inspiralling compact binaries with the proposed LISA space interferometer. Specifically, we estimate lower bounds on the coupling parameter \omega of scalar-tensor theories of the Brans-Dicke type and on the Compton wavelength of the graviton \lambda_g in hypothetical massive graviton theories. In these theories, modifications of the gravitational radiation damping formulae or of the propagation of the waves translate into a change in the phase evolution of the observed gravitational waveform. We obtain the bounds through the technique of matched filtering, employing the LISA Sensitivity Curve Generator (SCG), available online. For a neutron star inspiralling into a 10^3 M_sun black hole in the Virgo Cluster, in a two-year integration, we find a lower bound \omega > 3 * 10^5. For lower-mass black holes, the bound could be as large as 2 * 10^6. The bound is independent of LISA arm length, but is inversely proportional to the LISA position noise error. Lower bounds on the graviton Compton wavelength ranging from 10^15 km to 5 * 10^16 km can be obtained from one-year observations of massive binary black hole inspirals at cosmological distances (3 Gpc), for masses ranging from 10^4 to 10^7 M_sun. For the highest-mass systems (10^7 M_sun), the bound is proportional to (LISA arm length)^{1/2} and to (LISA acceleration noise)^{-1/2}. For the others, the bound is independent of these parameters because of the dominance of white-dwarf confusion noise in the relevant part of the frequency spectrum. These bounds improve and extend earlier work which used analytic formulae for the noise curves.Comment: 16 pages, 9 figures, submitted to Classical & Quantum Gravit

Cosmological Simulations of Normal-Branch Braneworld Gravity

We introduce a cosmological model based on the normal branch of DGP braneworld gravity with a smooth dark energy component on the brane. The expansion history in this model is identical to LambdaCDM, thus evading all geometric constraints on the DGP cross-over scale r_c. This model can serve as a first approximation to more general braneworld models whose cosmological solutions have not been obtained yet. We study the formation of large scale structure in this model in the linear and non-linear regime using N-body simulations for different values of r_c. The simulations use the code presented in (F.S., arXiv:0905.0858) and solve the full non-linear equation for the brane-bending mode in conjunction with the usual gravitational dynamics. The brane-bending mode is attractive rather than repulsive in the DGP normal branch, hence the sign of the modified gravity effects is reversed compared to those presented in arXiv:0905.0858. We compare the simulation results with those of ordinary LambdaCDM simulations run using the same code and initial conditions. We find that the matter power spectrum in this model shows a characteristic enhancement peaking at k ~ 0.7 h/Mpc. We also find that the abundance of massive halos is significantly enhanced. Other results presented here include the density profiles of dark matter halos, and signatures of the brane-bending mode self-interactions (Vainshtein mechanism) in the simulations. Independently of the expansion history, these results can be used to place constraints on the DGP model and future generalizations through their effects on the growth of cosmological structure.Comment: 17 pages, 10 figures; v2: minor changes; v3: references added; v4: added appendix on comparison with previous results; matches published version; v5: corrected Eqs. (2.4-2.5) and Fig. 1 following Ref. [28]; all following results unchange

Self-Consistent Cosmological Simulations of DGP Braneworld Gravity

We perform cosmological N-body simulations of the Dvali-Gabadadze-Porrati braneworld model, by solving the full non-linear equations of motion for the scalar degree of freedom in this model, the brane bending mode. While coupling universally to matter, the brane-bending mode has self-interactions that become important as soon as the density field becomes non-linear. These self-interactions lead to a suppression of the field in high-density environments, and restore gravity to General Relativity. The code uses a multi-grid relaxation scheme to solve the non-linear field equation in the quasi-static approximation. We perform simulations of a flat self-accelerating DGP model without cosmological constant. The results of the DGP simulations are compared with standard gravity simulations assuming the same expansion history, and with DGP simulations using the linearized equation for the brane bending mode. This allows us to isolate the effects of the non-linear self-couplings of the field which are noticeable already on quasi-linear scales. We present results on the matter power spectrum and the halo mass function, and discuss the behavior of the brane bending mode within cosmological structure formation. We find that, independently of CMB constraints, the self-accelerating DGP model is strongly constrained by current weak lensing and cluster abundance measurements.Comment: 21 pages; 10 figures. Revised version matching published versio