Editor\u27s Introduction -- lustitia on Women

One positive aspect of a newly organized publication is the opportunity for experimentation. With this issue, lustitia will for the first time be devoted to one area of current social concern-the Women\u27s Movement. Women\u27s struggle for equality is not a recent phenomenon in this country but a recurring one. Thus, in the early 1970\u27s we find women struggling with many issues, new and old. The editors of this issue present to the readers some of the frontier issues of the Movement today

Editor\u27s Introduction -- lustitia on Women

One positive aspect of a newly organized publication is the opportunity for experimentation. With this issue, lustitia will for the first time be devoted to one area of current social concern-the Women\u27s Movement. Women\u27s struggle for equality is not a recent phenomenon in this country but a recurring one. Thus, in the early 1970\u27s we find women struggling with many issues, new and old. The editors of this issue present to the readers some of the frontier issues of the Movement today

Responses

Editor and author comments on articles from this issue

The Corner

The clang of the door caused Roger\u27s stomach to tighten, as he stood helplessly watching that black iron thing restricting his freedom. Several minutes later he turned and glanced around the cell . .. only wanting to learn the room well enough not to fall over anything. The ultimate insult of nothingness surrounded Roger. He fell on the bunk and stared ... then slept. An hour later Roger jerked awake at the sound of a metal key turning in the lock. Walking in with Sheriff Conrad was the Probation Officer, Mr. Wilson. He was a smiling young guy who talked nice . they alwaxs talked nice . . . Roger knew . . . knew not to trust him

Responses

Editor and author comments on articles from this issue

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric mTOR complex 1 (mTORC1) inhibitors, are active in mantle cell lymphoma and other lymphoid neoplasms, but responses are usually partial and short-lived. In the present study we compared the effects of rapamycin with the dual mTORC1/mTORC2 inhibitor OSI-027 in cell lines and clinical samples representing divers lymphoid malignancies. In contrast to rapamycin, OSI-027 markedly diminished proliferation and induced apoptosis in a variety of lymphoid cell lines and clinical samples, including specimens of B-cell acute lymphocytic leukemia (ALL), mantle cell lymphoma, marginal zone lymphoma and Sezary syndrome. Additional analysis demonstrated that OSI-027–induced apoptosis depended on transcriptional activation of the PUMA and BIM genes. Overexpression of Bcl-2, which neutralizes Puma and Bim, or loss of procaspase 9 diminished OSI-027–induced apoptosis in vitro. Moreover, OSI-027 inhibited phosphorylation of mTORC1 and mTORC2 substrates, up-regulated Puma, and induced regressions in Jeko xenografts. Collectively, these results not only identify a pathway that is critical for the cytotoxicity of dual mTORC1/mTORC2 inhibitors, but also suggest that simultaneously targeting mTORC1 and mTORC2 might be an effective anti-lymphoma strategy in vivo