9 research outputs found
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles
- Author
- Adamski J. (Jerzy)
- Aulchenko Y.S. (Yurii)
- Axenovich T.I. (Tatiana)
- Biloglav Z. (Zrinka)
- Broer L. (Linda)
- Campbell H. (Harry)
- Campbell S. (Susan)
- Demirkan A. (AyĆe)
- Dharuri H. (Harish)
- Domingues I. (InĂȘs)
- Duijn C.M. (Cornelia) van
- Floyd J. (Jamie)
- Franke L. (Lude)
- Franklin C.S. (Christopher)
- Gieger C. (Christian)
- Gnewuch C. (Carsten)
- Gyllensten U. (Ulf)
- Hastie N. (Nick)
- Hayward C. (Caroline)
- Henneman P. (Peter)
- Hettne K.M. (Kristina)
- Hicks A.A. (Andrew)
- Hoen P.A.C. (Peter) 't
- Hofman A. (Albert)
- Huffman J.E. (Jennifer)
- Igl W. (Wilmar)
- Isaacs A.J. (Aaron)
- Jansen R.C. (Ritsert)
- Janssens A.C.J.W. (CĂ©cile)
- Johansson A. (Ă sa)
- Jonasson I. (Inger)
- Karssen L.C. (Lennart)
- Kirichenko A.V. (Anatoly)
- Klinken J.B. (Jan) van
- Kolcic I. (Ivana)
- Liebisch G. (Gerhard)
- Meitinger T. (Thomas)
- Mook-Kanamori D.O. (Dennis)
- Oostra B.A. (Ben)
- Pattaro C. (Cristian)
- Pfeufer A. (Arne)
- Pichler I. (Irene)
- Polasek O. (Ozren)
- Pramstaller P.P. (Peter Paul)
- Rivadeneira Ramirez F. (Fernando)
- Roos M. (Marco)
- Rudan I. (Igor)
- Schmitz G. (Gerd)
- Struchalin M.V. (Maksim)
- Suhre K. (Karsten)
- Ugocsai P. (Peter)
- Uitterlinden A.G. (André)
- Vitart V. (Veronique)
- Wang-Sattler R. (Rui)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Wilson J.F. (James F)
- Witteman J.C.M. (Jacqueline)
- Wright A.F. (Alan)
- Zaboli G. (Ghazal)
- Zorkoltseva I.V. (Irina)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/12/2013
- Field of study
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest effect sizes. In contrast, SNPs that associate with metabolite levels generally explain a higher percentage of the genetic variation and demonstrate larger effect sizes. Still, the discovery of SNPs associated with metabolite levels is challenging since testing all metabolites measured in typical metabolomics studies with all SNPs comes with a severe multiple testing penalty. We have developed an automated workflow approach that utilizes prior knowledge of biochemical pathways present in databases like KEGG and BioCyc to generate a smaller SNP set relevant to the metabolite. This paper explores the opportunities and challenges in the analysis of GWAS of metabolomic phenotypes and provides novel insights into the genetic basis of metabolic variation through the re-analysis of published GWAS datasets. Results: Re-analysis of the published GWAS dataset from Illig et al. (Nature Genetics, 2010) using a pathway-based workflow (http://www.myexperiment.org/packs/319.html), confirmed previously identified hits and identified a new locus of human metabolic individuality, associating Aldehyde dehydrogenase family1 L1 (ALDH1L1) with serine/glycine ratios in blood. Replication in an independent GWAS dataset of phospholipids (Demirkan et al., PLoS Genetics, 2012) identified two novel loci supported by additional literature evidence: GPAM (Glycerol-3 phosphate acyltransferase) and CBS (Cystathionine beta-synthase). In addition, the workflow approach provided novel insight into the affected pathways and relevance of some of these gene-metabolite pairs in disease development and progression. Conclusions: We demonstrate the utility of automated exploitation of background knowledge present in pathway databases for the analysis of GWAS datasets of metabolomic phenotypes. We report novel loci and potential biochemical mechanisms that contribute to our understanding of the genetic basis of metabolic variation and its relationship to disease development and progression
Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures
- Author
- Adams J.D. (John D.)
- Agel J. (Julie)
- Ahn H. (Henry)
- Ahn J. (Jaimo)
- Albers G.H.R. (G.H. Robert)
- Alexander D. (David)
- Alosky R. (Rachel)
- Amirault J.D. (J. David)
- Amundsen A. (Asgeir)
- Anand S. (Sanjeev)
- Anderson C.G. (Christopher G.)
- Anderson L.K. (Linda K.)
- Anderson S.A. (Sarah A.)
- Apostle K. (Kelly)
- Archdeacon M. (Michael)
- Arora V. (Vinod)
- Aurang K. (Kamran)
- Avram V. (Victoria)
- Axelrod T. (Terry)
- Baele J. (Joseph)
- Baker J.K. (Janell K.)
- Bannister E.R. (Evan R.)
- Bardana D. (Davide)
- Barden B.B. (Benjamin B.)
- Beckish M.L. (Michael L.)
- Bedi H. (Harvinder)
- Ben Schmidt G. (G.)
- Bhandari M. (Mohit)
- Bhatia M. (Mahesh)
- Bicknell R. (Ryan)
- Biddulph M. (Michael)
- Bielby S.A. (Shea A.)
- Biert J. (Jan)
- Blokhuis T.J. (Taco J.)
- Borch T. (Tor)
- Borsella V. (Vivian)
- Bosma J. (Jan)
- Bosman C.H.R. (Coks H.R.)
- Bowler C. (Carol)
- Boxma H. (Han)
- Boyer D. (Dory)
- Brattgjerd J.E. (Jan Egil)
- Brekke A.C. (Anne Christine)
- Brennan M.L. (Michael L.)
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- Brien H. (Heather)
- Broderick J.S. (J. Scott)
- Brom H.L.F.
- Bronkhorst M.W.G.A. (Maarten)
- Browner K. (Kieran)
- Bruijninckx M.M.M. (Milko)
- Buckingham L. (Lisa)
- Buckley R.E. (Richard E.)
- Bucknill A. (Andrew)
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- Zurcher A.W. (Arthur W.)
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/05/2018
- Field of study
Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo
Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin
- Author
- Anderson A. (Aparna)
- Anderson L.N. (Laura)
- Bakker S.J.L. (Stephan)
- Bandinelli S. (Stefania)
- Bolton J.L. (Jennifer)
- Campbell H. (Harry)
- Davey-Smith G. (George)
- Direk N. (Nese)
- Dullaart R.P.F. (Robin)
- Eriksson J. (Joel)
- Evans D.M. (David)
- Ferrucci L. (Luigi)
- Hagen K. (Knut)
- Hammond G.L. (Geoffrey)
- Harst P. (Pim) van der
- Hastie N. (Nick)
- Hayward C. (Caroline)
- Hill L.A. (Lesley)
- Hofman A. (Albert)
- Huffman J.E. (Jennifer)
- Ingelsson E. (Erik)
- Jarvelin M.-R. (Marjo-Riitta)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Lahti J. (Jari)
- Lewis J.G. (John)
- Lind L. (Lars)
- Lindgren C.M. (Cecilia)
- Lye S.J. (Stephen)
- Mahajan A. (Anubha)
- Matthews S.G. (Stephen)
- Mellström D. (Dan)
- Milaneschi Y. (Yuri)
- Morris A.P. (Andrew)
- Ohlsson C. (Claes)
- Palotie A. (Aarno)
- Pennell C.E. (Craig)
- Price J.F. (Jackie F.)
- Reynolds R.M. (Rebecca)
- Ring S.M. (Susan)
- Rosmalen J.G.M. (Judith)
- Rudan I. (Igor)
- RÀikkönen K. (Katri)
- St Pourcain B. (Beate)
- Strachan M.W.J. (Mark W.)
- Tanaka T. (Toshiko)
- Tiemeier H.W. (Henning)
- Timpson N.J. (Nicholas)
- Uitterlinden A.G. (André)
- Velders F.P. (Fleur)
- Verweij N. (Niek)
- Walker B.R. (Brian)
- Widen E. (Elisabeth)
- Wild S.H. (Sarah)
- Wilson J.F. (James)
- Wright A. (Alan)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Author
- Abecasis G. (Gonçalo)
- Almgren P. (Peter)
- Amin N. (Najaf)
- Amouyel P. (Philippe)
- Arking D.E. (Dan)
- Attia J. (John)
- Ayers K.L. (Kristin)
- Barbieri C.M. (Caterina M.)
- Barnes M.J. (Michael)
- Batini C. (Chiara)
- Bis J.C. (Joshua)
- Blake T. (Tineka)
- Bochud M. (Murielle)
- Boehnke M. (Michael)
- Boerwinkle E. (Eric)
- Boomsma D.I. (Dorret I.)
- Bottinger E.P. (Erwin P.)
- Boutin T. (Thibaud)
- Braund P.S. (Peter)
- Brown M.J. (Morris)
- Brumat M. (Marco)
- Butterworth A.S. (Adam S.)
- Cabrera C.P. (Claudia P.)
- Campbell A. (Archie)
- Campbell H. (Harry)
- Caulfield M. (Mark)
- Chakravarti A. (Aravinda)
- Chambers J.C. (John C.)
- Chasman D.I. (Daniel)
- Chauhan G. (Ganesh)
- Cho K. (Kelly)
- Ciullo M. (Marina)
- Cocca M. (Massimiliano)
- Collins F. (Francis)
- Conen D. (David)
- Connell J. (John)
- Cordell H.J. (Heather)
- Cucca F. (Francesco)
- Danesh J. (John)
- Davies G. (Gail)
- de Borst M.H. (Martin H.)
- Deary I.J. (Ian)
- Debette S. (Stéphanie)
- Deelen J. (Joris)
- Del Greco M F. (Fabiola)
- Demirkale C.Y. (Cumhur Yusuf)
- Dimou N. (Niki)
- Ding J. (Jun)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Dörr M. (Marcus)
- Edwards T.L. (Todd L.)
- Ehret G.B. (Georg B.)
- Elliott P. (Paul)
- Elosua R. (Roberto)
- Enroth S. (Stefan)
- Erzurumluoglu A.M. (A. Mesut)
- Esko T. (Tonu)
- Evangelou E. (Evangelos)
- Evangelou M. (Marina)
- Farrall M. (Martin)
- Ferreira T. (Teresa)
- Franco O.H. (Oscar)
- FrÄnberg M. (Mattias)
- Gandin I. (Ilaria)
- Gao H. (He)
- Gasparini P. (Paolo)
- Gaziano J.M. (J. Michael)
- Geus E.J.C. (Eco) de
- Giedraitis V. (Vilmantas)
- Gieger C. (Christian)
- Giri A. (Ayush)
- Girotto G. (Giorgia)
- Giulianini F. (Franco)
- Goel A. (Anuj)
- Gow A.J. (Alan J.)
- Gudnason V. (Vilmundur)
- Guo X. (Xiuqing)
- Gyllensten U. (Ulf)
- Hamsten A. (Anders)
- Harris S.E. (Sarah)
- Harris T.B. (Tamara)
- Hartman C.A. (Catharina A.)
- Havulinna A.S. (Aki)
- Hayward C. (Caroline)
- Hellwege J.N. (Jacklyn N.)
- Hicks A.A. (Andrew A.)
- Hofer E. (Edith)
- Hofman A. (Albert)
- Holliday E.G. (Elizabeth)
- Hottenga J.J. (Jouke Jan)
- Howson J.M.M. (Joanna M. M.)
- Huffman J.E. (Jennifer E.)
- Hung A.M. (Adriana M.)
- Hwang S.-J. (Shih-Jen)
- Ingelsson E. (Erik)
- Jackson A.U. (Anne)
- James A. (Alan)
- Jansen R. (Rick)
- Jarvelin M.-R. (Marjo-Riitta)
- Joehanes R. (Roby)
- Johansson A. (Ă sa)
- Johnson A.D. (Andrew)
- Joshi P.K. (Peter K.)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kao W.H.L. (Wen)
- Karaman I. (Ibrahim)
- Kathiresan S. (Sekar)
- Keavney B.D. (Bernard D.)
- Khaw K.-T. (Kay-Tee)
- Knekt P.
- Knight J. (Joanne)
- Kolcic I. (Ivana)
- Kooner J.S. (Jaspal S.)
- Koskinen S. (Seppo)
- Kovesdy C.P. (Csaba P.)
- Kristiansson K. (Kati)
- Kutalik Z. (ZoltĂĄn)
- KÀhönen M. (Mika)
- Laakso M. (Markku)
- Laan M. (Maris)
- Lakatta E.G. (Edward G.)
- Langenberg C. (Claudia)
- Larson M.G. (Martin)
- Launer L.J. (Lenore)
- Lehne B. (Benjamin)
- LehtimÀki T. (Terho)
- Levy D. (Daniel)
- Li-Gao R. (Ruifang)
- Liewald D.C.M. (David C. M.)
- Lin L. (Li)
- Lin W.-Y. (Wei-Yu)
- Lindgren C.M. (Cecilia M.)
- Liu Y. (YongMei)
- Loos R.J.F. (Ruth)
- Lopez L.M. (Lorna)
- Lu Y. (Yingchang)
- Luan J.
- LyytikÀinen L.-P. (Leo-Pekka)
- Mahajan A. (Anubha)
- Mamasoula C. (Chrysovalanto)
- Mangino M. (Massimo)
- Marrugat J. (Jaume)
- Marten J. (Jonathan)
- McG Thom S.A.
- Melander O. (Olle)
- Menni C. (Cristina)
- Metspalu A. (Andres)
- Mifsud B. (Borbala)
- Milaneschi Y. (Yuri)
- Milani L. (Lili)
- Mook-Kanamori D.O. (Dennis O.)
- Morgan A. (Anna)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Morrison A.C. (Alanna)
- Mosen-Ansorena D. (David)
- Most P.J. (Peter) van der
- Munroe P. (Patricia)
- Munson P.J. (Peter)
- Mutsert R. (Reneé) de
- MĂ€gi R. (Reedik)
- Nalls M.A. (Michael)
- Nandakumar P. (Priyanka)
- Nelson C.P. (Christopher P.)
- Newton-Cheh C. (Christopher)
- Ng F.L. (Fu Liang)
- Nguyen Q.T. (Quang Tri)
- Niiranen T. (Teemu)
- Nolte I.M. (Ilja)
- Noordam R. (Raymond)
- Ntritsos G. (Georgios)
- Nutile T. (Teresa)
- Oldehinkel A.J. (Albertine)
- Oldmeadow C. (Christopher)
- Oostra B.A. (Ben)
- Org E. (Elin)
- OâReilly P.F. (Paul F.)
- Padmanabhan S. (Sandosh)
- Palmas W. (Walter)
- Palmer C.N.A. (Colin N. A.)
- Palotie A. (Aarno)
- Pare G. (Guillame)
- Pattie A. (Alison)
- Pazoki R. (Raha)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Peters A. (Annette)
- Polasek O. (Ozren)
- Poulter N.R. (Neil)
- Pramstaller P.P. (Peter Paul)
- Prins B.P. (Bram Peter)
- Psaty B.M. (Bruce)
- Qian Y. (Yong)
- Raitakari O. (Olli)
- Ren M. (Meixia)
- Rettig R. (Rainer)
- Rice K.M. (Kenneth)
- Ridker P.M. (Paul)
- Ried J.S. (Janina S.)
- Riese H. (Harriëtte)
- Ripatti S. (Samuli)
- Risch L. (Lorenz)
- Robino A. (Antonietta)
- Rose L.M. (Lynda M.)
- Rotter J.I. (Jerome I.)
- Rudan I. (Igor)
- Ruggiero D.
- Saba Y. (Yasaman)
- Sala C. (Cinzia)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh J.)
- Sargurupremraj M. (Muralidharan)
- Sarin A.-P.
- Schmidt H. (Helena)
- Schmidt R. (Reinhold)
- Scott R.A. (Robert)
- Scott R.J. (Rodney J.)
- Sever P. (Peter)
- Shah N. (Nisha)
- Shields D.C. (Denis C.)
- Shrine N.R.G. (Nick)
- Siscovick D. (David)
- Smith A.V. (Albert)
- Snieder H. (Harold)
- Sorice R.
- Spector T.D. (Timothy)
- Stanton A. (Alice)
- Starr J.M. (John)
- Stott D.J. (David. J.)
- Strachan D.P. (David)
- Strawbridge R.J. (Rona)
- Sun Y.V. (Yan V.)
- Sundström J. (Johan)
- Surendran P. (Praveen)
- Swertz M.A. (Morris A.)
- SÔber S. (Siim)
- Taylor K.D. (Kent)
- Teumer A. (Alexander)
- Thériault S. (Sébastien)
- Tobin M.D. (Martin)
- Tomaszewski M. (Maciej)
- Toniolo D. (Daniela)
- Traglia M. (Michela)
- Trompet S. (Stella)
- Tsao P.S. (Philip S.)
- Tuomilehto J. (Jaakko)
- Tzanis E. (Evan)
- Tzoulaki I.
- Tzourio C. (Christophe)
- Uitterlinden A.G. (André)
- Vaez A. (Ahmad)
- van der Harst P. (Pim)
- Velez Edwards D.R. (Digna R.)
- Vergnaud A.-C. (Anne-Claire)
- Verweij N. (Niek)
- Verwoert G.C. (Germaine C.)
- Vitart V. (Veronique)
- Vollenweider P. (Peter)
- Vuckovic D. (Dragana)
- Völker U. (Uwe)
- Wain L.V. (Louise V.)
- Wareham N.J. (Nick)
- Warren H. (Helen)
- Watkins H. (Hugh)
- Wild S.H. (Sarah)
- Willems S.M. (Sara)
- Willemsen G. (Gonneke)
- Wilson J.F. (James F.)
- Wilson P.W.F. (Peter W. F.)
- Witkowska K. (Katarzyna)
- Wright A.F. (Alan)
- Yao J. (Jie)
- Zeggini E. (Eleftheria)
- Zemunik T. (Tatijana)
- Zhang W. (Weihua)
- Zhao J.-H. (Jing-Hua)
- Ădonnell C.J. (Christopher)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/11/2018
- Field of study
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML.
The error has now been corrected in the HTML version of the paper
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9)
- Author
- Abecasis G.R. (Goncalo R.)
- Altshuler D. (David)
- Amin N. (Najaf)
- Amin N. (Najaf)
- An P. (Ping)
- Bakker S.J.L. (Stephan)
- Balkau B. (Beverley)
- Bandinelli S. (Stefania)
- Barroso I.E. (InĂȘs)
- Bennett A.J. (Amanda J.)
- Bergman R.N. (Richard N.)
- Bielak L.F. (Lawrence F.)
- BlĂŒher M. (Matthias)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boerwinkle E.A. (Eric)
- Boettcher Y. (Yvonne)
- Bonnefond A. (Amélie)
- Boomsma D.I. (Dorret I.)
- Bornstein S.R. (Stefan)
- Bouatia-Naji N. (Nabila)
- Campbell H. (Harry)
- Campbell S. (Susan)
- Carlson O.D. (Olga)
- Dedoussis G.V. (George)
- Deloukas P. (Panos)
- Dimas A.S. (Antigone)
- Dimitriou M. (Maria)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Egan J. (Josephine)
- Eriksson P. (Per)
- Esko T. (TÔnu)
- Fadista J. (JoĂŁo)
- Faggian A. (Alessia)
- Faire U.D. (Ulf)
- Fall T. (Tove)
- Ferrucci L. (Luigi)
- Ford I. (Ian)
- Forouhi N.G. (Nita)
- Franco-Cereceda A. (Anders)
- Franks P.W. (Paul W.)
- Frants R.R. (Rune)
- Fraser R.M. (Ross)
- Frayling T.M. (Timothy M.)
- Froguel P. (Philippe)
- Ganna A. (Andrea)
- Geus E.J.C. (Eco) de
- Giedraitis V. (Vilmantas)
- Gieger C. (Christian)
- Goel A. (Anuj)
- Grallert H. (Harald)
- Groop L. (Leif)
- Groves C.J. (Christopher J.)
- Gudnason V. (Vilmundur)
- GĂ„din J.R. (Jesper R.)
- Hamsten A. (Anders)
- Harris T.B. (Tamara)
- Harst P. (Pim van der)
- Hastie N. (Nick)
- Hayward C. (Caroline)
- Herder C. (Christian)
- Hicks A.A. (Andrew A.)
- Hingorani A. (Aroon)
- Hofman A. (Albert)
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (G. Kees)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iperen E. (Erik van)
- Isaacs A.J. (Aaron)
- Jackson A.U. (Anne U.)
- Jansen R. (Rick)
- Jarvelin M.-R. (Marjo-Riitta)
- Jiang L. (Longda)
- Johnson P.C.D. (Paul C. D.)
- Johnson T. (Toby)
- Jukema J.W. (Jan Wouter)
- Kaakinen M.A. (Marika A.)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Kardia S.L.R. (Sharon L. R.)
- Karpe F. (Fredrik)
- Keinanen-Kiukaanniemi S. (Sirkka)
- KieĂ W. (Wieland)
- Kinnunen L. (Leena)
- Kivimaki M. (Mika)
- Kleber M.E. (Marcus E.)
- Koistinen H.A. (Heikki A.)
- Kovacs P. (Peter)
- Krus U. (Ulrika)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Körner A. (Antje)
- Laakso M. (Markku)
- Lagou V. (Vasiliki)
- Lakka T.A. (Timo)
- Langenberg C. (Claudia)
- Lecoeur C. (CĂ©cile)
- Li G. (Guo)
- Lindgren C.M. (Cecilia M.)
- Lindström J. (Jaana)
- Liu Y. (Yongmei)
- Loos R.J.F. (Ruth J. F.)
- Luan J. (Jianâan)
- Lyssenko V. (Valeriya)
- Magnusson P.K. (Patrik)
- Mahajan A. (Anubha)
- Marullo L. (Letizia)
- Matullo G.
- McCarthy M.I. (Mark I.)
- McLachlan S. (Stela)
- Meigs J.B. (James B.)
- Meitinger T. (Thomas)
- Meneton P. (Pierre)
- Metspalu A. (Andres)
- Meyer J. (Julia)
- Mihailov E. (Evelin)
- Miljkovic I. (Iva)
- Min J.L. (Josine L.)
- Montasser M.E. (May E.)
- Morris A.P. (Andrew)
- Munroe P. (Patricia)
- MĂ€gi R. (Reedik)
- MÀnnistö S. (Satu)
- MĂ€rz W. (Winfried)
- MĂŒller-Nurasyid M. (Martina)
- Navarro P. (Pau)
- Nicholson G. (George)
- Nolte I.M. (Ilja)
- OâConnell J.R. (Jeff R.)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Palmer L.J. (Lyle J.)
- Pedersen N.L. (Nancy)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Peyser P.A. (Patricia A.)
- Polasek O. (Ozren)
- Pourcain B.S. (Beate St)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter Paul)
- Price J.F. (Jackie F.)
- Prokopenko I. (Inga)
- Province M.A. (Michael A.)
- Rasmussen-Torvik L.J. (Laura)
- Rauramaa R. (Rainer)
- Rayner N.W. (Nigel William)
- Rudan I. (Igor)
- Rybin D. (Denis)
- Saaristo T. (Timo)
- Salo P. (Perttu)
- Salomaa V. (Veikko)
- Sanna S. (Serena)
- Sarin A.-P.
- Sattar N. (Naveed)
- Scapoli C. (Chiara)
- Schwarz P.E.H. (Peter)
- Shin S.-Y.
- Shuldiner A.R. (Alan R.)
- Shungin D. (Dmitry)
- Sijbrands E.J.G. (Eric)
- Silbernagel G. (GĂŒnther)
- Siscovick D.S. (David)
- Smith A.V. (Albert)
- Smith G.D. (George Davey)
- Snieder H. (Harold)
- Soranzo N. (Nicole)
- Stafford M.
- Stathopoulou M.G. (Maria G)
- Strawbridge R.J. (Rona)
- Stumvoll M. (Michael)
- Tanaka T. (Toshiko)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Timpson N.J. (Nicholas J.)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Ulrich A. (Anna)
- Uusitupa M. (Matti)
- Verweij N. (Niek)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vollenweider P. (Peter)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Webster R.J. (Rebecca J.)
- Wild S.H. (Sarah)
- Willems S.M. (Sara)
- Willemsen G. (Gonneke)
- Wilson J.F. (James F.)
- Winkelmann B.
- Wolffenbuttel B.H.R. (Bruce)
- Wright A.F. (Alan F.)
- Yengo L. (Loic)
- Zemunik T. (Tatijana)
- Zudina L. (Liudmila)
- Zwart J-A. (John-Anker)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/02/2021
- Field of study
The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently swapped. This has now been corrected in the PDF and HTML versions of the Article
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial
- Author
- Adams J.D. (John D.)
- Agel J. (Julie)
- Ahn H. (Henry)
- Ahn J. (Jaimo)
- Albers G.H.R. (G.H. Robert)
- Alexander D. (David)
- Alosky R. (Rachel)
- Amirault J.D. (J. David)
- Amundsen A. (Asgeir)
- Anand S. (Sanjeev)
- Anderson C.G. (Christopher G.)
- Anderson L.K. (Linda K.)
- Anderson S.A. (Sarah A.)
- Apostle K. (Kelly)
- Archdeacon M. (Michael)
- Arora V. (Vinod)
- Aurang K. (Kamran)
- Avram V. (Victoria)
- Axelrod T. (Terry)
- Baele J. (Joseph)
- Baker J.K. (Janell K.)
- Bannister E.R. (Evan R.)
- Bardana D. (Davide)
- Barden B.B. (Benjamin B.)
- Beckish M.L. (Michael L.)
- Bedi H. (Harvinder)
- Bhandari Mohit
- Bhatia M. (Mahesh)
- Bicknell R. (Ryan)
- Biddulph M. (Michael)
- Bielby S.A. (Shea A.)
- Biert Jan
- Blokhuis T.J. (Taco J.)
- Borch T. (Tor)
- Borsella V. (Vivian)
- Bosma J. (Jan)
- Bosman C.H.R. (Coks H.R.)
- Bowler C. (Carol)
- Boxma Han
- Boyer D. (Dory)
- Brattgjerd J.E. (Jan Egil)
- Brekke A.C. (Anne Christine)
- Brennan M.L. (Michael L.)
- Breslin M. (Mary)
- Brien H. (Heather)
- Broderick J.S. (J. Scott)
- Brom H.L.F.
- Bronkhorst Maarten
- Browner K. (Kieran)
- Bruijninckx Milko
- Buckingham L. (Lisa)
- Buckley R.E. (Richard E.)
- Bucknill A. (Andrew)
- Buijk S.E. (Steven E.)
- Butler M.S. (Mark S.)
- Bzovsky S. (Sofia)
- BĂže B. (Berthe)
- Caminiti S. (Stephanie)
- Campo M. (Martin)
- Cannada L.K. (Lisa K.)
- Cantu R.V. (Robert V.)
- Carcary K. (Kimberly)
- Carlisle H. (Hope)
- Carr A. (Ashley)
- Cass J.R. (Joseph R.)
- Charlton M. (Michael)
- Cherian J.J. (Joe Joseph)
- Chia A. (Andrew)
- Chuter G. (Graham)
- Clark C. (Callum)
- Clarke-Jenssen J. (John)
- Clarkson R. (Rachel)
- Cleffken Berry
- Clipper L. (Lydia)
- Coady C. (Catherine)
- Cole P.A. (Peter A.)
- Coles C. (Chad)
- Creek A.T. (Aaron T.)
- Crist B.D. (Brett D.)
- Cross W.W. (William W.)
- Csongvay S. (Steve)
- Cuento C. (Claudine)
- Curry H. (Hamish)
- Dadi A. (Akhil)
- Davis C.A. (Craig A.)
- Dawson Imro
- Dawson S.A. (Sarah A.)
- de Brauw M. (Maurits)
- de Meulemeester F.R.A.J. (Frank R.A.J.)
- de Mol van Otterloo A. (Alexander)
- de Rooij P.D. (Peter D.)
- de Vries Reilingh T.S. (Tammo S.)
- de Vries J.P.P.M. (Jean Paul P.M.)
- de Waal Malefijt M.C. (Maarten C.)
- DePaolo C.J. (Charles J.)
- Devereaux P.J. (P. J.)
- Dobb C. (Christine)
- Dobbin G. (Gwendolyn)
- Dohm M.P. (Michael P.)
- Doig S. (Stephen)
- Dolenc A. (Andrea)
- Donald G. (Geoff)
- Donegan D. (Derek)
- Donohue C. (Craig)
- Doornebosch Pascal
- Dowrick A. (Adam)
- Duffy P. (Paul)
- Dulaney-Cripe L. (Liz)
- Dumais J. (Jules)
- Dunbar M. (Michael)
- Duraikannan A. (Aravin)
- Edison M. (Matt)
- Edwards E. (Elton)
- Edwards Michael
- Eickhoff L.S. (Linda S.)
- Eke K. (Kate)
- EkÄs G. (Guri)
- Elst Maarten
- Endres T.J. (Terrence J.)
- Ertl J.P. (Janos P.)
- Erwin K. (Katie)
- Esser M. (Max)
- Esterhai J. (John)
- Etherington G. (Greg)
- Evans A. (Andrew)
- Evans S. (Simone)
- Eversdijk Martin
- Fan M. (Mary)
- Farrell D.J. (Dana J.)
- Farrugia R.J. (Richard J)
- Festen Sebastiaan
- Ficke J. (James)
- Finley S.H. (Stephen H.)
- Finn E. (Erin)
- Finnan R. (Ryan)
- Fioole Bram
- FlatĂžy B. (Bernhard)
- Flynn A. (Annette)
- Foley A.L. (Amy L.)
- Foret J.L. (Jonathan L.)
- Frihagen Frede
- Frizzell V. (Valda)
- Frölke Jan Paul
- Ganguly U. (Utsav)
- Gardeniers J.W.M. (Jean W.M.)
- Garfi J.S. (John S.)
- Garibaldi A. (Alisha)
- Gayton C. (Chris)
- Geeraedts L.M.G. (Leo M.G.)
- Gervais T. (Trevor)
- Ghent W. (Wesley)
- Gibula D. (Douglas)
- Gichuru M. (Mark)
- Gissel H. (Hannah)
- Glazebrook M. (Mark)
- Go P.M.N.Y.M. (Peter M.N.Y.M.)
- Goetz D.R. (David R.)
- Gofton W.T. (Wade T.)
- Gong A. (Andrew)
- Gorczyca J.T. (John T.)
- Goslings Carel
- Govaert L. (Lonneke)
- Graaf Eelco
- Groenendijk Richard
- Gross J.M. (Jonathan M.)
- Gross M. (Michael)
- Gruen G. (Gary)
- Gudger G.K. (Garland K.)
- Guicherit O.R. (Onno R.)
- Gupta A. (Ajay)
- Gurich R.W. (Richard W.)
- Guyatt G. (Gordon)
- Hak D. (David)
- Hall J.A. (Jeremy A.)
- Halliday B. (Brett)
- Hammacher Eric
- Hammerberg E.M. (E. Mark)
- Hampton L. (Lynne)
- Hanusch B.C. (Birgit C.)
- Harrison M. (Mark)
- Hart Cor P.
- Hartog Dennis
- Hasselund S. (Sondre)
- Haverlag Robert
- Heels-Ansdell Diane
- Heetveld Martin
- Heijden Frank
- Hemlock K. (Kim)
- Henderson C. (Corey)
- Henderson E.R. (Eric R.)
- Herriott C. (Chris)
- Hesketh P.J. (Patrick J.)
- Hess S. (Shelley)
- Hewitt M. (Michael)
- Hidy J.T. (Jennifer T.)
- Hileman B. (Barbara)
- Hill A.D. (Austin D.)
- Hjorthaug G. (Geir)
- Hoffman J.M. (Jodi M.)
- Hoffman W.H. (W. H.)
- Hollenbeck S.M. (Steven M.)
- Holt M. (Michael)
- Hoogendoorn J. (Jochem)
- Horan A.D. (Annamarie D.)
- Horner G. (Gillian)
- Horwitz D. (Daniel)
- Hoseth T.M. (Tor Magne)
- Howells F. (Fiona)
- Hsu J.R. (Joseph R.)
- Huff R.B. (Roger B.)
- Hull P. (Peter)
- Humphrey C.A. (Catherine A.)
- Hurley M. (Meghan)
- Ianssen T. (Torben)
- Inman D. (Dominic)
- Iorio R. (Richard)
- Irrgang J. (James)
- Jackson L.T. (Lyle T.)
- Jain A. (Arvind)
- Jain N. (Neeraj)
- Jenkins M. (Mark)
- Jenkinson R. (Richard)
- Jennings A. (Andrew)
- Jeray K.J. (Kyle J.)
- Johal H. (Herman)
- Johnson G. (Garth)
- Johnston D. (David)
- Johnston K. (Kelly)
- Jomaas G. (Geir)
- Jones C.B. (Clifford B.)
- Jones V. (Vicki)
- Josaputra H.A. (Hong A.)
- JĂžrgen Haug K. (Knut)
- Kain M.S.H. (Michael S.H.)
- Kampen A.
- Karges D.E. (David E.)
- Karlsten A. (Anders)
- Karsten Thomas
- Kates S. (Stephen)
- Keeve J.P. (Jonathan P.)
- Keller P. (Paul)
- Ketz J.P. (John P.)
- Khan F. (Farah)
- Khan R.M. (Ryan M.)
- Khanna A. (Angshuman)
- KibsgÄrd T. (Thomas)
- Kile E. (Evelyn)
- Kingwell S.P. (Stephen P.)
- Knobe M. (Matthias)
- Koppert C.L. (Cees L.)
- Korley R. (Robert)
- Kottam L. (Lucksy)
- Kreder H. (Hans)
- Kregor P. (Philip)
- Kruse K.K. (Kevin K.)
- Kuiken H. (Hans)
- Kunz M. (Monica)
- Lackey W.G. (Wesley G.)
- Lafferty P.M. (Paul M.)
- Lambert S. (Sue)
- Langan J.W. (Justin W.)
- Laughlin R. (Richard)
- Lawendy A.-R. (Abdel-Rahman)
- Lawson D. (Deanna)
- Le T. (Toan)
- Lee Murphy R. (R.)
- Lee J. (Julia)
- Leenen Luke
- Leffler L.C. (Lauren C.)
- Leighton R. (Ross)
- Lemke H.M. (H. Michael)
- Lewis C.G. (Courtland G.)
- Lewis S. (Sophie)
- Li D. (Doug)
- Li M. (Mengnai)
- Lieberman S. (Shane)
- Liem R. (Ronald)
- Lieshout Esther
- Liew A. (Allen)
- Liew S. (Susan)
- Lindenbaum S. (Stephen)
- Linehan C. (Colleen)
- Lobo M.J. (Margaret J.)
- Logishetty R. (Rajanikanth)
- Lona T. (Tarjei)
- Lorenzo M. (Melissa)
- Love D. (David)
- Luther A. (Arlene)
- Ly T.V. (Thuan V.)
- Lyle L. (Lindsey)
- MacDonald S. (Shelley)
- MacLeod M. (Mark)
- Maddock D. (Deborah)
- Marcantonio A.J. (Andrew J.)
- Marston S.B. (Scott B.)
- Mauffrey C. (Cyril)
- May J. (Jedediah)
- McBeth J.C. (Jessica Cooper)
- McCormack R. (Robert)
- McDonald M.D. (Michael D.)
- McIntyre A.W. (Allison W.)
- McKay P. (Paula)
- McKee M.D. (Michael D.)
- McKercher R. (Ross)
- Mehta S. (Samir)
- Meijer J. (Joost)
- Meylaerts Sven
- Miller R. (Russell)
- Miller T.J. (Timothy J.)
- Mills K. (Kelli)
- Milner K. (Katrine)
- Mishra V. (Vimlesh)
- Mitchell K. (Khalis)
- Moatshe G. (Gilbert)
- Moaveni A. (Ash)
- Molund M. (Marius)
- Monica J.T. (James T.)
- Moola F. (Farhad)
- Moon K. (Karyn)
- Moon R. (Raely)
- Moore M.M. (Molly M.)
- Mullis B. (Brian)
- Murdoch Z. (Zoe)
- Murnaghan J. (John)
- Murtha Y.M. (Yvonne M.)
- MĂŒller O. (Oliver)
- Nam D. (Diane)
- Nanda R. (Rajesh)
- Nanney T. (Tracy)
- Napierala M. (Matthew)
- Nastoff L.A. (Lauren A.)
- Naumetz V. (V.)
- Nauth A. (Aaron)
- Newman H. (Heike)
- Nicolaisen T. (Tor)
- Nies Frank
- Nilsen F. (Fredrik)
- Noble K. (Krista)
- Nousiainen M. (Markku)
- O'Malley L.K. (Lawrence K.)
- O'Neil J. (Joseph)
- Oatt A. (Amber)
- Obremskey W. (William)
- Olakkengil D.J. (Davy J)
- Oliver T.M. (Todd M.)
- Oprel Pim
- Out N.J.M. (Nico J.M.)
- Oxner W. (William)
- Pace T.B. (Thomas B.)
- Palla N. (Naveen)
- Pape H.-C. (Hans-Christoph)
- Papp S. (Steve)
- Parr J.A. (J. Andrew)
- Patka Peter
- Payton K. (Krystal)
- Pecorella K. (Kaili)
- Perey B. (Bertrand)
- Peters M.E. (Melissa E.)
- Peters R. (Rolf)
- Peterson B. (Brett)
- Pfeifer R. (Roman)
- Pilling L. (Lindsey)
- Pincus P. (Paul)
- Pirpiris M. (Marinis)
- Poelhekke L.M.S.J.
- Pol Carmen
- Ponsen Kees-jan
- Poolman Rudolf
- Porter S.E. (Scott E.)
- Pourmand D. (Deeba)
- Powell J. (James)
- Prasad A.S. (Amal Shankar)
- Prayson M.J. (Michael J.)
- Price D.M. (Dustin M.)
- Probe R. (Robert)
- Puloski S. (Shannon)
- Rai A. (Anil)
- Rai B.S. (B. Sachidananda)
- Rai K. (Kamal)
- Rajakumar J. (Janakiraman)
- Rangan A. (Amar)
- Reardon G. (Gerald)
- Reed Mike
- Reeves C. (Christina)
- Rhemrev Steven
- Richards J.E. (Justin E.)
- Richardson C.G. (C. Glen)
- Richardson M. (Martin)
- Rieser G.R. (Geoffrey Ryan)
- Rijbroek B. (Bram)
- Rijcke Piet
- Rijna H.
- Ringler J.R. (James R.)
- Ritchie E.D. (Ewan D.)
- Robbins K. (Kristin)
- Rocca G.J.D. (Gregory J. Della)
- Roffey D.M. (Darren M.)
- Romero A.W. (Amanda W.)
- Roper E. (Elizabeth)
- Rose G. (Glynis)
- Roukema Gert
- Rubino L.J. (L. Joseph)
- Russ M. (Matthias)
- Rutherford T. (Tori)
- Rydinge J. (Jonas)
- Sage C. (Claire)
- Sagebien C.A. (Carlos A.)
- Sanders D. (David)
- Sanghavi A. (Amir)
- Schaller T.M. (Thomas M.)
- Scheepers Joris J.
- Schemitsch Emil
- Schep Niels
- Schmidt A.H. (Andrew H.)
- Schmidt G.B. (G. Ben)
- Schreurs B. (Bart)
- Schrickel T. (Tyson)
- Schwappach J. (John)
- Scott T. (Taryn)
- Scrabeck T. (Tyson)
- Segers M.J.M. (Michiel J.M.)
- Segers Michiel
- Sems S.A. (Stephen A.)
- Seuffert P. (Patricia)
- Shaer J. (James)
- Sharma A. (Ateet)
- Sharma G. (Gaurav)
- Shell L.E. (Leslie E.)
- Shepard S. (Stephanie)
- Shively K. (Karl)
- Sietsema D.L. (Debra L.)
- Silva H. (Heather)
- Silvis R. (Rob)
- Simmermacher R.K.J.
- Simons M.P.
- Simunovic N. (Nicole)
- Simunovic N. (Nicole)
- Singh S. (Sanjay)
- Siroen M.P.C. (Michiel P.C.)
- Siska P. (Peter)
- Slobogean G.P. (Gerard P.)
- Smedsrud M. (Morten)
- Smits A.B. (Anke B.)
- Snellen J.P. (Jaap P.)
- Snider R.G. (Rebecca G.)
- Specht L.M. (Lawrence M.)
- Sprague S. (Sheila)
- Stahel P. (Philip)
- Stassen Laurents
- Stephen D. (David)
- Stinner D. (Daniel)
- Stockmann H. (Heyn)
- Stone T. (Trevor)
- Stringfellow K. (Kenya)
- Strohecker K. (Kent)
- Stull P. (Philip)
- StĂždle A. (Are)
- Subash ()
- Sullivan R.J. (Raymond J.)
- Sundaresh D.C. (D. C.)
- Swenson T.K. (Teresa K.)
- Swinton M. (Marilyn)
- Swiontkowski Marc
- Switzer J.A. (Julie A.)
- Tan E.T.C.H. (Edward T.C.H.)
- Tanksley J.A. (John A.)
- Tanner S.L. (Stephanie L.)
- Tannoury C. (Chadi)
- Tarkin I. (Ivan)
- Teasdall R.J. (Robert J.)
- Tetsworth K. (Kevin)
- Tetteroo Geert
- Thabane Lehana
- Theunissen E.B.M. (Evert B.M.)
- Tieszer C. (Christina)
- Tilzey J.F. (John F.)
- Ton L. (Lu)
- Torchia M.E. (Michael E.)
- Tornetta Paul
- Torres E.T. (Erick T.)
- Trask K. (Kelly)
- Trenholm J.A. (J. Andrew)
- Trivedi M. (Mittal)
- Trommer A. (Axel)
- Turckan K. (Kahn)
- Tyagi V. (Vivek)
- Tynan M.C. (Martin C.)
- Ugland S. (Stein)
- Vallier H.A. (Heather A.)
- van der Brand I. (Igor)
- van der Hoeven H. (Henk)
- van Egmond T. (Teun)
- van Gaalen S.M. (Steven M.)
- van Mulken J. (Jeroen)
- van Vugt A.B. (Arie B.)
- van ât Riet M. (Martijne)
- Vang S. (Sandy)
- Verhagen R. (Ronald)
- Verhoeven B. (Bart)
- Verhofstad Michiel
- Vermeulen E.G.J. (Erik G.J.)
- Vesterhus E.B. (Elise Berg)
- Vicente M.R. (Milena R.)
- Vis Harm
- Viskontas D. (Darius)
- Visser G.A. (Gijs A.)
- Viveiros Helena
- Vogt M. (Michelle)
- Vries Alexander
- Vries Mark
- Vuylsteke R. (Ronald)
- Wadey V. (Veronica)
- Waes Oscar
- Wai E.K. (Eugene K.)
- Walker J.E. (Jane E.)
- Walter S.D. (Stephen D.)
- Wang O. (Otis)
- Ward A. (Angela)
- Watson D.J. (Dylan J.)
- Watson S.T. (Scott T.)
- Weber T. (Timothy)
- Weening B. (Brad)
- Weinerman S. (Stuart)
- Weingarten P. (Peter)
- Weinrauch P. (Patrick)
- Wessel R.N. (Ronald N.)
- Wessem K.J.P.
- Westberg J.R. (Jerald R.)
- Whatley E. (Erica)
- Whelan D.B. (Daniel B.)
- Wild L.M. (Lisa M.)
- Wille Jan
- Willems Jaap
- Wittich Philippe
- Wong I. (Ivan)
- Wood G. (Gavin)
- Worman R. (Ripley)
- Wright D.M. (David M.)
- Wyrick J. (John)
- Yach J. (Jeff)
- Yadav V. (Vineet)
- Yang S. (Steven)
- Yee A. (Albert)
- Yen D. (David)
- Yu M. (Michelle)
- Zalzal P. (Paul)
- Zamorano D.P. (David P.)
- Zellar A. (Abby)
- Zhou Q. (Qi)
- Zielinski Stephanie
- Zijl J.A.C. (Jacco A.C.)
- Zohman G. (Gary)
- Zomar M. (Mauri)
- Zurcher A.W. (Arthur W.)
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/04/2017
- Field of study
Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between Mar
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (InĂȘs)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Cavalcanti-Proença C. (Christine)
- Chambers J.C. (John C.)
- Chambers J.C. (John)
- Chanock S.J. (Stephen)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chatterjee N. (Nilanjan)
- Chen C.-M. (Chih-Mei)
- Chen H. (Han)
- Chen L. (Li)
- Chines P.S. (Peter)
- Cichon S. (Sven)
- Clarke R.
- Clarke R. (Robert)
- Codd V. (Veryan)
- Coin L. (Lachlan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Collins F.S. (Francis)
- Connell J. (John)
- Cooper C. (Charles)
- Cooper C.C. (Cyrus C.)
- Cooper M.N. (Matthew N.)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Cupples L.A. (Adrienne)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Davies R.W. (Robert)
- Day I.N.M. (Ian N.M.)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Demissie S. (Serkalem)
- Den Heijer M. (Martin)
- Dennison E.M. (Elaine)
- Dermitzakis E.T. (Emmanouil T.)
- Devaney J.M. (Joseph M.)
- Di Meglio P. (Paola)
- Diemert P. (Patrick)
- Dimas A.S. (Antigone)
- Dina C. (Christian)
- Dixon A.L. (Anna)
- Do R. (Ron)
- Doering A. (Angela)
- Doney A.S.F. (Alex)
- Donnelly P. (Peter)
- Duan J. (Jubao)
- Duijn C.M. (Cornelia) van
- Dupuis J. (Josée)
- Durbin R. (Richard)
- Ebrahim S. (Shah)
- Ebrahim S. (Shanil)
- Eifert S. (Sandra)
- Eiriksdottir G. (Gudny)
- El Mokhtari N.E. (Nour Eddine)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Ellis S.G. (Stephen)
- Elosua R. (Roberto)
- Engert J.C. (James C.)
- Epstein S.E. (Stephen)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Eriksson P. (Per)
- Esko T. (Tonu)
- Esko T. (TÔnu)
- Estrada Gil K. (Karol)
- Eury E. (Elodie)
- Faire U. (Ulf) de
- Farooqi I.S. (I. Sadaf)
- Farooqi I.S. (Sadaf)
- Farrall M. (Martin)
- Feitosa M.F. (Mary Furlan)
- Felix S.B. (Stephan)
- Ferrannini E. (Ele)
- Ferreira T. (Teresa)
- Fischer M. (Marcus)
- Fischer-Posovszky P. (Pamela)
- Florez J.C. (Jose)
- Folkersen L. (Lasse)
- Folsom A.R. (Aaron)
- Forsen T. (Tom)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy)
- Freimer N.B. (Nelson B.)
- Freyer J. (Jennifer)
- Friedrich N. (Nele)
- Froguel P. (Philippe)
- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
- Green T. (Todd)
- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- GrĂ€sler J. (JĂŒrgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
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- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
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- Hedman A.K. (Asa)
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- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
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- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
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- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
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- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- KilpelÀinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (ZoltĂĄn)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (CĂ©cile)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
- Liu J. (Jianjun)
- Lokki M.L.
- Loley C. (Christina)
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Lotery A.J. (Andrew)
- Luan J.
- Ludwig B. (Barbara)
- Lyssenko V. (Valeriya)
- Macciardi F. (Fabio)
- Makrilakis K. (Konstantinos)
- Mallick C.B. (Chandana Basu)
- Mannila M.N. (Maria Nastase)
- Manning A.K. (Alisa)
- Mannucci P.M. (Pier)
- Manunta P. (Paolo)
- Maouche S. (Seraya)
- Marek D. (Diana)
- Marre M. (Michel)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- McCarroll S.A. (Steven)
- McCarthy A. (Anne)
- McCarthy M. (Mark)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
- McKnight B. (Barbara)
- McPherson R. (Ruth)
- Meigs J.B. (James)
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- Meitinger T. (Thomas)
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- Merlini P.A. (Pier Angelica)
- Metspalu A. (Andres)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Min J. (Josine)
- Mohlke K.L. (Karen L.)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant)
- Montgomery G.W. (Grant)
- Mooser V. (Vincent)
- Morgan T. (Thomas)
- Morken M.A. (Mario)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew)
- Muhlestein J.B. (Joseph)
- Mulic R. (Rosanda)
- Munroe P. (Patricia)
- Munroe P.B. (Patricia B.)
- Munzel T. (Thomas)
- Musunuru K. (Kiran)
- Myers R.H. (Richard)
- MĂ€gi R. (Reedik)
- MĂ€larstig A. (Anders)
- MĂ€rz W. (Winfried)
- Nahrstaedt J. (Janja)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Navarro P. (Pau)
- Nelis M. (Mari)
- Nelson C.P. (Christopher P.)
- Nemesh J. (James)
- Nestle F.O. (Frank)
- Neville M.J. (Matthew)
- Ngwa J.S.
- Nica A. (Alexandra)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nisbet J. (James)
- North K.E. (Kari)
- Nyholt D.R. (Dale)
- Nöthen M.M. (Markus)
- O'Connell J.R. (Jeffrey R.)
- O'Donnell C.J. (Christopher)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Stephen)
- O'Rahilly S. (Steve)
- Offer A. (Alison)
- Ohlsson C. (Claes)
- Olivieri O. (Oliviero)
- Olsson G.
- Ongen H. (Halit)
- Oostra B.A. (Ben)
- Osmond C. (Clive)
- Ouwehand W.H. (Willem)
- Owen K.R. (Katharine)
- OÂŽConnell J.R.
- Palmer C.N.A. (Colin)
- Pankow J.S. (James)
- Pare G. (Guillame)
- Park J.H.
- Parker A.N. (Alex)
- Parts L. (Leopold)
- Pascoe L. (Laura)
- Patel R.S. (Riyaz)
- Patterson C.C. (Chris C.)
- Payne F. (Felicity)
- Peden J. (John)
- Pedersen O. (Oluf)
- Pellikka N. (Niina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John)
- Peters A. (Annette)
- Peters M.J. (Marjolein)
- Petersen A.K.
- Peto R. (R.)
- Petrie J.R. (John)
- Peyvandi F. (Flora)
- Pichler I. (Irene)
- Pietilainen K.H. (Kirsi Hannele)
- Platou C. (Carl)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Potter S.C. (Simon)
- Pramstaller P.P. (Peter P.)
- Preuss M. (Michael)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Purcell S. (Shaun)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
- Rader D.J. (Daniel)
- Rafelt S. (Suzanne)
- Raitakari O. (Olli)
- Raitakari O.T. (Olli T.)
- Rallidis L.S. (Loukianos)
- Randall J.C. (Joshua)
- Rasheed A. (Asif)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (N. William)
- Rayner N.W. (Nigel William)
- Reilly M.P. (Muredach P.)
- Reinehr T. (Thomas)
- RidderstrÄle M. (Martin)
- Ridker P.M. (Paul)
- Rij A.M. (Andre) van
- Ripatti S. (Samuli)
- Rissanen A. (Aila)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Rosendaal F.R. (Frits R.)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rust S. (Stephan)
- Rybin D. (Denis)
- Rzehak P. (Peter)
- Sabater-Lleal M. (Maria)
- Saleheen D. (Danish)
- Salomaa V. (Veikko)
- Samad A. (Adbus)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampietro M.L. (Maria Lourdes)
- Sampson M.J. (Michael)
- Samuel M. (Maria)
- Sanders A.R. (Alan R.)
- Sandholt C. (Camilla)
- Sandhu M.S. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Saramies J. (Jouko)
- Savolainen M.J. (Markku)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric)
- Scherag A. (Andre)
- Schillert A. (Arne)
- Schipf S. (Sabine)
- Schlessinger D. (David)
- Schreiber S. (Stefan)
- Schrezenmeir J. (JĂŒrgen)
- Schunkert H. (Heribert)
- Schwartz S.M. (Stephen)
- Schwarz P.E.H. (Peter)
- SchÀfer A. (Arne)
- Scott J. (James)
- Scott L.J. (Laura)
- Scott L.J. (Laura)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Sehmi J.S. (Joban)
- Sekowska M. (Magdalena)
- Sennblad B. (Bengt)
- Serrano-RĂos M. (Manuel)
- Shah N. (Nisha)
- Shi J. (Jianxin)
- Shi J. (Jianxin)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Sivapalaratnam S. (Suthesh)
- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Stephens J. (Jonathan)
- Stewart A.F. (Alexandre F.)
- Stirrups K. (Kathy)
- Stoll M. (Monika)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
- Taneera J. (Jalal)
- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas)
- Tognoni G.
- Tomaszewski M. (Maciej)
- Travers M.E. (Mary E.)
- Travers M.E. (Mary)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Turrini F. (Fabiola)
- Tyrer J.P. (Jonathan)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- Van Dam R.M. (Rob M.)
- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (GĂ©rard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
- Wild S.H. (Sarah)
- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (InĂȘs)
- Barroso I.E. (InĂȘs)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boehnke M. (Michael)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
- Boerwinkle E.A. (Eric)
- Bonnefond A. (Amélie)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret I)
- Boomsma D.I. (Dorret I.)
- Boomsma D.I. (Dorret)
- Borch-Johnsen K.
- Borecki I.B. (Ingrid B)
- Borja J.B. (Judith)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bravenboer B. (Bert)
- Brunner E. (Eric)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Bumpstead S. (Suzannah)
- Burtt N.P. (Noël P.)
- Burtt N.P. (Noël)
- Buxbaum S.G. (Sarah)
- Böhringer S. (Stefan)
- Böttcher Y. (Yvonne)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Campbell H. (Harry)
- Cao A. (Antonio)
- Carlson O.D. (Olga)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Caulfield M.J. (Mark J.)
- Cavalcanti-Proença C. (Christine)
- Chambers J. (John)
- Chambers J.C. (John C.)
- Charpentier G. (Guillaume)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chen I. (Ida)
- Chen Y.-D.I. (Yii-Der Ida)
- Chen Y.D.I. (Yii-Der Ida)
- Chines P.S. (Peter S.)
- Chines P.S. (Peter)
- Cho Y.S. (Yoon Shin)
- Clarke R. (Robert)
- Coassin S. (Stefan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Cooper C. (Charles)
- Cooper C. (Cyrus)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Cornelis M. (Marilyn)
- Couper D.J. (David J.)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Crawford G. (Gabe)
- Crawford G. (Gabriel)
- Crisponi L. (Laura)
- Croteau-Chonka D.C. (Damien)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Dastani Z. (Zari)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Deloukas P. (Panagiotis)
- Delplanque J. (Jerome)
- DIAGRAM+ Consortium
- Dina C. (Christian)
- Dina C. (Christian)
- Dominiczak A. (Anna)
- Dominiczak A.F. (Anna F.)
- Doney A.S.F. (Alex S. F.)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Duncan B.B. (Bruce)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Dupuis J. (Josée)
- Döring A. (Angela)
- Ebrahim S. (Shanil)
- Egan J.M. (Josephine)
- Egan J.M. (Josephine)
- Ejebe K.G. (Kenechi)
- Elliott A.L. (Amanda)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Erdmann J. (Jeanette)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Erdos M.R. (Michael)
- Evans D.M. (David)
- Faire U. (Ulf) de
- Fedson A.C. (Annette)
- Feitosa M.F. (Mary Furlan)
- Ferreira T. (Teresa)
- Ferrucci L. (Luigi)
- Ferrucci L. (Luigi)
- Fischer-Rosinsky A. (Antje)
- Florez J.C. (Jose C.)
- Florez J.C. (Jose)
- Florez J.C. (Jose)
- Forouhi N.G. (Nita)
- Fouchier S.W. (Sigrid)
- Fox C.S. (Caroline)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Franklin C.S. (Christopher)
- Franks P.W. (Paul)
- Frants R. (Rune)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy M.)
- Frayling T.M. (Timothy)
- Froguel P. (Philippe)
- Froguel P. (Philippe)
- Fuchsberger C. (Christian)
- Gabriel S.B. (Stacey)
- Galan P. (Pilar)
- Ganser M. (Martha)
- Garcia M.E. (M.)
- Geus E.J.C. (Eco) de
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Gieger C. (Christian)
- Glazer N.L. (Nicole)
- GLGC Investigators
- Gloyn A.L. (Anna L.)
- Gloyn A.L. (Anna)
- Go M.J. (Min Jin)
- Goel A. (Anuj)
- Gonzalez E. (Elena)
- Goodarzi M. (Mark)
- Graessler J. (JĂŒrgen)
- Grallert H. (Harald)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Grarup N. (Niels)
- Green T. (Todd)
- Greenwood C.M.T. (Celia)
- Griffin S. (Simon)
- Grimsby J. (Jonna)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Groves C.J. (Christopher)
- Grundy S.M. (Scott)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Guiducci C. (Candace)
- Guo X. (Xiuqing)
- Guo X. (Xiuqing)
- Gwilliam R. (Rhian)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair)
- Hallmans G. (Göran)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Han X. (Xijing)
- Hansen T. (Torben)
- Haritunians T. (Talin)
- Harris T.B. (Tamara B.)
- Harris T.B. (Tamara)
- Hartikainen A.L.
- Hassanali N. (Neelam)
- Hassanali N. (Neelam)
- Hastie N. (Nick)
- Hattersley A.T. (Andrew)
- Haun M. (Margot)
- Havulinna A.S. (Aki)
- Hayward C.
- Hayward C. (Caroline)
- Heath S.C. (Simon)
- Heemst D. (Diana) van
- Hegele R.A. (Robert)
- Heid I.M. (Iris)
- Heid I.M. (Iris)
- Hengstenberg C. (Christian)
- Henneman P. (Peter)
- Henneman P. (Peter)
- Hercberg S. (Serge)
- Herder C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew A.)
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hillman D.R. (David)
- Hingorani A. (Aroon)
- Hitman G.A. (Graham)
- Hivert M.-F. (Marie-France)
- Hoek M. (Mandy) van
- Hofman A.
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Hottenga J.J. (Jouke Jan)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (Kees)
- Hu F.B. (Frank B)
- Hu F.B. (Frank B.)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Hung J. (Joe)
- Hunter D.J. (David)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Ingelsson E. (Erik)
- Isaacs A. (Aaron)
- Isaacs A.J. (Aaron)
- Isomaa B. (Bo)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jackson A.U. (Anne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Jarvelin M.-R. (Marjo-Riitta)
- Johansen C.T. (Christopher)
- Johansson A. (Ă sa)
- Johnson P.R.V. (Paul R. V.)
- Johnson P.R.V. (Paul)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jorgensen T. (Torben)
- Jorgensen T. (Torben)
- Jula A. (Antti)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kanaya A. (Alka)
- Kanoni S. (Stavroula)
- Kanoni S. (Stavroula)
- Kao W.H.L. (W. H. Linda)
- Kao W.H.L. (Wen H. L.)
- Kao W.H.L. (Wen)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Katsareli E. (Efi)
- Kedenko L. (Lyudmyla)
- Kesaniemi Y.A. (Antero)
- Khaw K.-T. (Kay-Tee)
- Khaw K.T.
- Kim Y-J. (Yong-Jin)
- Kim Y.J.
- Kivimaki M. (Mika)
- Kizer J.R. (Jorge)
- Klopp N. (Norman)
- Klopp N. (Norman)
- Kloppenburg M. (Margreet)
- Knight B. (Beatrice)
- Kong A. (Augustine)
- Kong A. (Augustine)
- Kooner J. (Jaspal)
- Koseki M. (Masahiro)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Kristiansson K. (Kati)
- Kronenberg F. (Florian)
- Kronenberg F. (Florian)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Kuzawa C.W. (Christopher W.)
- Kuzawa C.W. (Christopher)
- Kyvik K.O. (Kirsten O.)
- Kyvik K.O. (Kirsten Ohm)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Ladouceur M. (Martin)
- Lajunen T. (Taina)
- Lakatta E.G. (Edward G.)
- Lamina C. (Claudia)
- Lamina C. (Claudia)
- Lange L.A. (Leslie)
- Lange L.A. (Leslie)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Lathrop G. (GMark)
- Launer L.J. (Lenore J.)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lecoeur C. (CĂ©cile)
- Lee J.-Y. (Jong-Young)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Li M. (Man)
- Li M. (Man)
- Li X. (Xiaohui)
- Li X. (Xiaohui)
- Li Y. (Yun)
- Lieverse A.G. (Aloysius)
- Lindgren C.M. (Cecilia M.)
- Lindgren C.M. (Cecilia)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Lohman K. (Kurt)
- Lokki M.L.
- Loo B.-M. (Britt-Marie)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Luan J. (Jianâan)
- Luan J. (Jianâan)
- Luben R.N. (Robert)
- Lucas G. (Gavin)
- Lyssenko V. (Valeriya)
- Lyssenko V. (Valeriya)
- LyytikÀinen L.-P. (Leo-Pekka)
- MAGIC Consortium
- Magnusson P.K. (Patrik)
- Magnusson P.K.E. (Patrik K. E.)
- Mahley R. (Robert)
- Mangino M. (Massimo)
- Mangino M. (Massimo)
- Manning A.K. (Alisa K.)
- Manning A.K. (Alisa)
- Marmot M. (Michael)
- Marre M. (Michel)
- Marroni F. (Fabio)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- Masson D. (David)
- McArdle W.L. (Wendy)
- McAteer J.B. (Jarred)
- McCarroll S.A. (Steve)
- McCarroll S.A. (Steven)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura J.)
- McCulloch L.J. (Laura)
- McPherson R. (Ruth)
- Meigs J.B. (James B.)
- Meigs J.B. (James)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Melzer D. (David)
- Meneton P. (Pierre)
- Meulenbelt I. (Ingrid)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Mitchell B.D. (Braxton)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen)
- Mooser V. (Vincent)
- Mooser V. (Vincent)
- Mooser V.E. (Vincent E.)
- Morken M.A. (Mario A.)
- Morken M.A. (Mario)
- Morris A.D. (Andrew D.)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew)
- Mukherjee S. (Sutapa)
- Munroe P. (Patricia)
- Musani S. (Solomon)
- Musunuru K. (Kiran)
- MuTHER Consortium
- MĂ€gi R. (Reedik)
- Naitza S. (Silvia)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Nathan D.M. (David)
- Navarro P. (Pau)
- Navarro P. (Pau)
- Neville M.J. (Matthew)
- Nickerson D.A. (Deborah A.)
- Nickerson D.A. (Deborah)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nuotio M.-L. (Marja-Liisa)
- Oostra B.A. (Ben A.)
- Oostra B.A. (Ben)
- Oostra B.A. (Ben)
- Ordovas J.M. (Jose M.)
- Ordovas J.M. (Jose)
- Orho-Melander M. (Marju)
- OrrĂč M. (Marco)
- Owen K.R. (Katharine)
- OâConnell J. (Jeffrey)
- Pakyz R. (Ruth)
- Palmer C. (Cameron)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Pankow J.S. (James S.)
- Pankow J.S. (James)
- Paolisso G. (Giuseppe)
- Pare G. (Guillame)
- Park T. (Taesung)
- Parker A.N. (Alex)
- Pattaro C. (Cristian)
- Pattaro C. (Cristian)
- Pattou F. (François)
- Paulweber B. (Bernhard)
- Payne F. (Felicity)
- Payne F. (Felicity)
- Pearson D. (Daniel)
- Peden J. (John)
- Pedersen N.L. (Nancy)
- Pedersen O. (Oluf)
- Pedersen O. (Oluf)
- Peloso G.M. (Gina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Penninx B.W.J.H. (Brenda W. J. H.)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John)
- Petersen A.K.
- Pfeiffer A.F.H. (Andreas)
- Pichler I. (Irene)
- Pichler I. (Irene)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Potter S.C. (Simon)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter Paul)
- Pramstaller P.P. (Peter Paul)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Province M.A. (Mike)
- Psaty B.M. (Bruce M.)
- Psaty B.M. (Bruce)
- Qi L. (Lu)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quertermous T. (Thomas)
- Rader D.J. (Daniel)
- Raitakari O. (Olli)
- Randall J.C. (Joshua)
- Rasmussen-Torvik L.J. (Laura)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (Nigel W.)
- Rayner N.W. (Nigel William)
- Redline S. (Susan)
- Reilly M.P. (Muredach P.)
- Rice K.M. (Kenneth)
- Richards J.B. (J. Brent)
- Ricketts S.L. (Sally)
- Ridker P.M. (Paul)
- Rieder M. (Mark)
- Rieder M. (Mark)
- Ripatti S. (Samuli)
- Ripatti S. (Samuli)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Robertson N.R. (Neil)
- Roccasecca R.M.
- Rocheleau G. (Ghislain)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Roden M. (Michael)
- Rolandsson O. (Olov)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Ruokonen A. (Aimo)
- Ruokonen A. (Aimo)
- Rybin D. (Denis)
- Sabatti C. (Chiara)
- Saharinen J. (Juha)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampson M.J. (Michael J)
- Sampson M.J. (Michael)
- Sandbaek A. (Annelli)
- Sandhu M. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Sanna S. (Serena)
- Sattar N. (Naveed)
- Saxena R. (Richa)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric E.)
- Schadt E.E. (Eric)
- Scheet P. (Paul)
- Schlessinger D. (David)
- Schlessinger D. (David)
- Schunkert H. (Heribert)
- Schwarz P.E.H. (Peter)
- Scott L.J. (Laura J.)
- Scott L.J. (Laura)
- Scott R.A. (Robert)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Seielstad M. (Mark)
- Semple R.K. (Robert K.)
- Serrano-RĂos M. (Manuel)
- Sethupathy P. (Praveen)
- Sharp S.J. (Stephen)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sigursson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric J. G.)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Silander K. (Kaisa)
- Silveira A. (Angela)
- Sim X. (Xueling)
- Sim X. (Xueling)
- Simpson L. (Laila)
- Singleton A. (Andrew)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Siscovick D.S. (David)
- Sladek R. (Rob)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Smith G.D. (George Davey)
- Smith J.D. (Joshua D.)
- Smith N.L. (Nicholas)
- Song K. (Kijoung)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Sovio U. (Ulla)
- SparsĂž T. (Thomas)
- SparsĂž T. (Thomas)
- Spector T.D. (Tim D.)
- Spector T.D. (Timothy D.)
- Spector T.D. (Timothy)
- Spranger J. (Joachim)
- St Pourcain B. (Beate)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Steinthorsdottir V. (Valgerdur)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Stylianou I.M. (Ioannis M.)
- Stylianou I.M. (Ioannis)
- Sun Q. (Qi)
- Surakka I. (Ida)
- Swift A.J. (Amy)
- Swift A.J. (Amy)
- Syddall H. (Holly)
- SyvÀnen A.C.
- Tai E.-S. (E-Shyong)
- Tai E.S. (Shyong)
- Tall A.R. (Alan R.)
- Tanaka T. (Toshiko)
- Taylor H.A. (Herman A.)
- Taylor H.A. (Herman)
- Teslovich T.M. (Tanya M.)
- Teslovich T.M. (Tanya M.)
- Thompson J.R. (John)
- Thompson J.R. (John)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas J.)
- Timpson N.J. (Nicholas)
- Tracy R.P. (Russell)
- Tuomi T. (Tiinamaija)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uda M. (Manuela)
- Uh H.-W. (Hae-Won)
- Uitterlinden A. (Andre)
- Uitterlinden A.G. (Andre G.)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- van Duijn C. (Cornelia)
- van Duijn C.M. (Cornelia M.)
- van Duijn C.M. (Cornelia M.)
- van Hoek M. (Mandy)
- Varma D. (Dhiraj)
- Viikari J. (Jorma)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Vogelzangs N. (Nicole)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Waeber G. (GĂ©rard)
- Waeber G. (GĂ©rard)
- Wagner P.J. (Peter)
- Walker M. (Mark)
- Walley A. (Andrew)
- Walters G. (GBragi)
- Walters G.B. (Bragi)
- Ward K.L. (Kim L.)
- Wareham N.J. (Nick J.)
- Wareham N.J. (Nick)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard M.)
- Watanabe R.M. (Richard)
- Waterworth D. (Dawn)
- Waterworth D. (Dawn)
- Waterworth D.M. (Dawn)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R.P. (Ryan)
- Wheeler E. (Eleanor)
- Whitfield J. (John)
- Wichmann H.-E. (H.-Erich)
- Wichmann H.E. (H. Erich)
- Wichmann H.E. (Heinz Erich)
- Wichmann H.E. (Heinz Erich)
- Wijmenga C. (Cisca)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Willems S.M. (Sara)
- Willems-vanDijk K. (Ko)
- Willemsen G.
- Willemsen G.A.H.M. (Gonneke)
- Willer C.J. (Cristen J.)
- Willer C.J. (Cristen)
- Williams G.H. (Gordon)
- Wilson J.F. (James F.)
- Wilson J.F. (James)
- Wilson J.G. (James G.)
- Winkler T.W. (Thomas W.)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline C. M.)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C. M.)
- Wong T.Y. (Tien Y.)
- Wood A.R. (Andrew)
- Wright A.F. (Alan)
- Wright A.F. (Alan)
- Wu G. (Guanming)
- Wu Y. (Ying)
- Yarnell J.W.G. (John W.)
- Yuan X. (Xin)
- Zabena C. (Carina)
- Zee R.Y.L. (Robert)
- Zeggini E. (Eleftheria)
- Zeggini E. (Eleftheria)
- Zelenika D. (Diana)
- Zethelius B. (Björn)
- Zhai G. (Guangju)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zwart J-A. (John-Anker)
- Ădonnell C.J. (Christopher)
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5Ă10â8- 1.2 Ă10â43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10â4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3Ă10â3, n = 22,044), increased triglycerides (p = 2.6Ă10â14, n = 93,440), increased waist-to-hip ratio (p = 1.8Ă10â5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4Ă10â3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5Ă10â13, n = 96,748) and decreased BMI (p = 1.4Ă10â4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial
- Author
- Aaron Nauth
- Aaron T. Creek
- Abby Zellar
- Abdel-Rahman Lawendy
- Adam Dowrick
- Ajay Gupta
- Akhil Dadi
- Albert van Kampen
- Albert Yee
- Alexander C. de Vries
- Alexander de Mol van Otterloo
- Alisha Garibaldi
- Allen Liew
- Allison W. McIntyre
- Amal Shankar Prasad
- Amanda W. Romero
- Amar Rangan
- Amber Oatt
- Amir Sanghavi
- Amy L. Foley
- Anders Karlsten
- Andrea Dolenc
- Andrew Bucknill
- Andrew Chia
- Andrew Evans
- Andrew Gong
- Andrew H. Schmidt
- Andrew J. Marcantonio
- Andrew Jennings
- Angela Ward
- Angshuman Khanna
- Anil Rai
- Anke B. Smits
- Annamarie D. Horan
- Anne Christine Brekke
- Annette Flynn
- Aravin Duraikannan
- Are StĂždle
- Arie B. van Vugt
- Arlene Luther
- Arthur W. Zurcher
- Arvind Jain
- Asgeir Amundsen
- Ash Moaveni
- Ashley Carr
- Ateet Sharma
- Austin D. Hill
- Axel Trommer
- B. Sachidananda Rai
- Barbara Hileman
- Barnes
- Bart Schreurs
- Bart Verhoeven
- BartonĂcek
- Bellamy
- Benjamin B. Barden
- Benterud
- Bernhard FlatĂžy
- Berry I. Cleffken
- Berthe BĂže
- Bertrand Perey
- Bhandari
- Bhandari
- Birgit C. Hanusch
- Blair
- Brad Weening
- Bram Fioole
- Bram Rijbroek
- Brett D. Crist
- Brett Halliday
- Brett Peterson
- Brian Mullis
- Brodetti
- Brooks
- C. Glen Richardson
- Callum Clark
- Carlos A. Sagebien
- Carmen C. van der Pol
- Carol Bowler
- Castillo
- Catherine A. Humphrey
- Catherine Coady
- Cees L. Koppert
- Chad Coles
- Chadi Tannoury
- Charles J. DePaolo
- Chris Gayton
- Chris Herriott
- Christina Reeves
- Christina Tieszer
- Christine Dobb
- Christopher G. Anderson
- Claire Sage
- Claudine Cuento
- Clifford B. Jones
- Coks H.R. Bosman
- Colleen Linehan
- Collett
- Cor P. van der Hart
- Corey Henderson
- Courtland G. Lewis
- Craig A. Davis
- Craig Donohue
- Cyril Mauffrey
- D.C. Sundaresh
- Dana J. Farrell
- Daniel B. Whelan
- Daniel Horwitz
- Daniel Stinner
- Darius Viskontas
- Darren M. Roffey
- David Alexander
- David E. Karges
- David Hak
- David Johnston
- David Love
- David M. Wright
- David P. Zamorano
- David R. Goetz
- David Sanders
- David Stephen
- David Yen
- Davide Bardana
- Davy J Olakkengil
- Deanna Lawson
- Deborah Maddock
- Debra L. Sietsema
- Deeba Pourmand
- Deneka
- Dennis Den Hartog
- Derek Donegan
- Diane Heels-Ansdell
- Diane Nam
- Dominic Inman
- Dory Boyer
- Doug Li
- Douglas Gibula
- Dustin M. Price
- Dylan J. Watson
- E. Mark Hammerberg
- Edward T.C.H. Tan
- Eelco J.R. de Graaf
- Elise Berg Vesterhus
- Elizabeth Roper
- Elton Edwards
- Emil H. Schemitsch
- Eric R. Hammacher
- Eric R. Henderson
- Erica Whatley
- Erick T. Torres
- Erik G.J. Vermeulen
- Erin Finn
- Esther M.M. Van Lieshout
- Eugene K. Wai
- Evan R. Bannister
- Evelyn Kile
- Evert B.M. Theunissen
- Ewan D. Ritchie
- Farah Khan
- Farhad Moola
- Fiona Howells
- Frank de Nies
- Frank H.W.M. van der Heijden
- Frank R.A.J. de Meulemeester
- Frede Frihagen
- Fredrik Nilsen
- G. Ben Schmidt
- G.H. Robert Albers
- Garden
- Garland K. Gudger
- Garth Johnson
- Gary Gruen
- Gary Zohman
- Gaurav Sharma
- Gavin Wood
- Geert W.M. Tetteroo
- Geir Hjorthaug
- Geir Jomaas
- Geoff Donald
- Geoffrey Ryan Rieser
- Gerald Reardon
- Gerard P. Slobogean
- Gert R Roukema
- Gijs A. Visser
- Gilbert Moatshe
- Gillian Horner
- Glynis Rose
- Gordon Guyatt
- Graham Chuter
- Greg Etherington
- Gregory J. Della Rocca
- Gullberg
- Guri EkÄs
- Gwendolyn Dobbin
- H. Michael Lemke
- Hamish Curry
- Han Boxma
- Hannah Gissel
- Hans Kreder
- Hans Kuiken
- Hans L.F. Brom
- Hans-Christoph Pape
- Harm M van der Vis
- Harper
- Harvinder Bedi
- Heather A. Vallier
- Heather Brien
- Heather Silva
- Heike Newman
- Helena Viveiros
- Henk van der Hoeven
- Henry Ahn
- Herman Johal
- Herman Rijna
- Heyn Stockmann
- Hong A. Josaputra
- Hope Carlisle
- Hoshino
- Igor van der Brand
- Imro Dawson
- Ivan Tarkin
- Ivan Wong
- J. Andrew Parr
- J. Andrew Trenholm
- J. Carel Goslings
- J. David Amirault
- J. Scott Broderick
- Jaap P. Snellen
- Jacco A.C. Zijl
- Jaimo Ahn
- James Ficke
- James Irrgang
- James Powell
- James R. Ringler
- James Shaer
- James T. Monica
- Jan Biert
- Jan Bosma
- Jan Egil Brattgjerd
- Jan Paul M. Frölke
- Jan Wille
- Janakiraman Rajakumar
- Jane E. Walker
- Janell K. Baker
- Janos P. Ertl
- Jean Paul P.M. de Vries
- Jean W.M. Gardeniers
- Jedediah May
- Jeff Yach
- Jennifer T. Hidy
- Jerald R. Westberg
- Jeremy A. Hall
- Jeroen van Mulken
- Jessica Cooper McBeth
- Jochem Hoogendoorn
- Jodi M. Hoffman
- Joe Joseph Cherian
- John A. Tanksley
- John Clarke-Jenssen
- John D. Adams
- John Esterhai
- John F. Tilzey
- John Murnaghan
- John P. Ketz
- John S. Garfi
- John Schwappach
- John T. Gorczyca
- John Wyrick
- Jonas Rydinge
- Jonathan L. Foret
- Jonathan M. Gross
- Jonathan P. Keeve
- Joost Meijer
- Joris J.G. Scheepers
- Joseph Baele
- Joseph O'Neil
- Joseph R. Cass
- Joseph R. Hsu
- Jules Dumais
- Julia Lee
- Julie A. Switzer
- Julie Agel
- Justin E. Richards
- Justin W. Langan
- Kahn Turckan
- Kaili Pecorella
- Kamal Rai
- Kamran Aurang
- Karl Shively
- Karlijn van Wessem
- Karyn Moon
- Kate Eke
- Katie Erwin
- Katrine Milner
- Kees Jan Ponsen
- Kelli Mills
- Kelly Apostle
- Kelly Johnston
- Kelly Trask
- Kent Strohecker
- Kenya Stringfellow
- Kevin K. Kruse
- Kevin Tetsworth
- Khalis Mitchell
- Kieran Browner
- Kim Hemlock
- Kimberly Carcary
- Knut JĂžrgen Haug
- Krista Noble
- Kristin Robbins
- Krystal Payton
- Kuokkanen
- Kyle J. Jeray
- L. Joseph Rubino
- Lauren A. Nastoff
- Lauren C. Leffler
- Laurents P.S. Stassen
- Law
- Lawrence K. O'Malley
- Lawrence M. Specht
- Lehana Thabane
- Leo M.G. Geeraedts
- Leslie E. Shell
- Linda K. Anderson
- Linda S. Eickhoff
- Linde
- Lindsey Lyle
- Lindsey Pilling
- Lisa Buckingham
- Lisa K. Cannada
- Lisa M. Wild
- Liz Dulaney-Cripe
- Lodewijk M.S.J. Poelhekke
- Lonneke Govaert
- Lu Ton
- Lucksy Kottam
- Luke P.H. Leenen
- Lydia Clipper
- Lyle T. Jackson
- Lynne Hampton
- Maarten C. de Waal Malefijt
- Maarten P. Simons
- Maarten van der Elst
- Maarten W.G.A. Bronkhorst
- Madsen
- Mahesh Bhatia
- Marc Swiontkowski
- Margaret J. Lobo
- Marilyn Swinton
- Marinis Pirpiris
- Marius Molund
- Mark Gichuru
- Mark Glazebrook
- Mark Harrison
- Mark Jenkins
- Mark MacLeod
- Mark R. de Vries
- Mark S. Butler
- Markku Nousiainen
- Martijne van 't Riet
- Martin C. Tynan
- Martin Campo
- Martin G. Eversdijk
- Martin J. Heetveld
- Martin Richardson
- Mary Breslin
- Mary Fan
- Matt Edison
- Matthew Napierala
- Matthias Knobe
- Matthias Russ
- Mauri Zomar
- Maurits de Brauw
- Max Esser
- McHorney
- Meghan Hurley
- Melissa E. Peters
- Melissa Lorenzo
- Mengnai Li
- Michael Archdeacon
- Michael Biddulph
- Michael Charlton
- Michael D. McDonald
- Michael D. McKee
- Michael Dunbar
- Michael E. Torchia
- Michael Gross
- Michael Hewitt
- Michael Holt
- Michael J. Prayson
- Michael J.R. Edwards
- Michael L. Beckish
- Michael L. Brennan
- Michael P. Dohm
- Michael S.H. Kain
- Michelle Vogt
- Michelle Yu
- Michiel H.J. Verhofstad
- Michiel J.M. Segers
- Michiel J.M. Segers
- Michiel P.C. Siroen
- Mike Reed
- Milena R. Vicente
- Milko M.M. Bruijninckx
- Mittal Trivedi
- Mohit Bhandari
- Molly M. Moore
- Monica Kunz
- Morten Smedsrud
- Mundi
- Naveen Palla
- Neeraj Jain
- Nico J.M. Out
- Nicole Simunovic
- Nicole Simunovic
- Niels W.L. Schep
- Nikolopoulos
- Oliver MĂŒller
- Onno R. Guicherit
- Oscar J.F. Van Waes
- Otis Wang
- Parker
- Parker
- Parker
- Pascal G. Doornebosch
- Patricia Seuffert
- Patrick J. Hesketh
- Patrick Weinrauch
- Paul Duffy
- Paul Keller
- Paul M. Lafferty
- Paul Pincus
- Paul Tornetta
- Paul Zalzal
- Paula McKay
- Paus
- Pauwels
- Peter A. Cole
- Peter D. de Rooij
- Peter Hull
- Peter M.N.Y.M. Go
- Peter Patka
- Peter Siska
- Peter Weingarten
- Philip Kregor
- Philip Stahel
- Philip Stull
- Philippe Wittich
- Piet A.R. de Rijcke
- Pim Oprel
- PJ Devereaux
- Qi Zhou
- R. Lee Murphy
- Rachel Alosky
- Rachel Clarkson
- Raely Moon
- Rajanikanth Logishetty
- Rajesh Nanda
- Raymond J. Sullivan
- Rebecca G. Snider
- Richard E. Buckley
- Richard Iorio
- Richard J Farrugia
- Richard Jenkinson
- Richard Laughlin
- Richard P.R. Groenendijk
- Richard W. Gurich
- Ripley Worman
- Rob Silvis
- Robert Haverlag
- Robert J. Teasdall
- Robert Korley
- Robert McCormack
- Robert Probe
- Robert V. Cantu
- Roger B. Huff
- Rogier K.J. Simmermacher
- Rolf Peters
- Roman Pfeifer
- Ronald Liem
- Ronald N. Wessel
- Ronald Verhagen
- Ronald Vuylsteke
- Ross Leighton
- Ross McKercher
- Rudolf W. Poolman
- Russell Miller
- Ryan Bicknell
- Ryan Finnan
- Ryan M. Khan
- Samir Mehta
- Sandy Vang
- Sanjay Singh
- Sanjeev Anand
- Sarah A. Anderson
- Sarah A. Dawson
- Scott
- Scott B. Marston
- Scott E. Porter
- Scott T. Watson
- Sebastiaan Festen
- Shane Lieberman
- Shannon Puloski
- Shea A. Bielby
- Sheila Sprague
- Shelley Hess
- Shelley MacDonald
- Simone Evans
- Sofia Bzovsky
- Sondre Hasselund
- Sophie Lewis
- Stein Ugland
- Stephanie Caminiti
- Stephanie L. Tanner
- Stephanie M. Zielinski
- Stephanie Shepard
- Stephen A. Sems
- Stephen D. Walter
- Stephen Doig
- Stephen H. Finley
- Stephen Kates
- Stephen Lindenbaum
- Stephen P. Kingwell
- Steve Csongvay
- Steve Papp
- Steven E. Buijk
- Steven J. Rhemrev
- Steven M. Hollenbeck
- Steven M. van Gaalen
- Steven Yang
- Stuart Weinerman
- Subash
- Sue Lambert
- Sun
- Sun
- Susan Liew
- Sven A.G. Meylaerts
- Swiontkowksi
- SĂžrensen
- Taco J. Blokhuis
- Tammo S. de Vries Reilingh
- Tarjei Lona
- Taryn Scott
- Teresa K. Swenson
- Terrence J. Endres
- Terry Axelrod
- Teun van Egmond
- Thomas B. Pace
- Thomas KibsgÄrd
- Thomas M. Schaller
- Thuan V. Ly
- Timothy J. Miller
- Timothy Weber
- Toan Le
- Todd M. Oliver
- Tom M. Karsten
- Tor Borch
- Tor Magne Hoseth
- Tor Nicolaisen
- Torben Ianssen
- Tori Rutherford
- Tracy Nanney
- Trevor Gervais
- Trevor Stone
- Tyson Schrickel
- Tyson Scrabeck
- Utsav Ganguly
- V. Naumetz
- Valda Frizzell
- Veronica Wadey
- Vicki Jones
- Victoria Avram
- Vimlesh Mishra
- Vineet Yadav
- Vinod Arora
- Vivek Tyagi
- Vivian Borsella
- W. Jaap Willems
- W.H. Hoffman
- Wade T. Gofton
- Watson
- Wesley G. Lackey
- Wesley Ghent
- William Obremskey
- William Oxner
- William W. Cross
- Yvonne M. Murtha
- Zielinski
- Zoe Murdoch
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study