Palaeolimnological evidence for eutrophication in Malham Tarn (SSSI), North Yorkshire

This is the final report to Natural England on the project “Palaeolimnological evidence for eutrophication in Malham Tarn (SSSI), North Yorkshire”. The aim is to seek palaeolimnological evidence for eutrophication in Malham Tarn both to complement and cross-validate contemporary and other historical evidence for such at the site, as well as to establish whether eutrophication-related changes in the aquatic macrophyte community occurred before the invasion of Elodea canadensis in 1962. Palaeolimnology is also used to assess whether there is evidence for eutrophication extending back to the 18th century as has been suggested (Pentecost, 1998; Bradley, 2007), and to aid in describing the unimpacted state of Malham Tarn and the setting of conservation targets

Saprolegnia diclina IIIA and S. parasitica employ different infection strategies when colonizing eggs of Atlantic salmon, Salmo salar L.

Acknowledgements The work has been funded by the European Commission through the EU Marie Curie ITN project SAPRO (238550) (MMS, AW). We would also like to acknowledge support from the BBSRC and the University of Aberdeen (PvW) and Landcatch and AquaGen for providing salmon eggs. Elin Rolen's assistance with sequencing of the strains is highly appreciated.Peer reviewedPublisher PD

Multi-frequency VLBA study of the blazar S5 0716+714 during the active state in 2004: I. Inner jet kinematics

We observed the blazar \object{0716+714} with the VLBA during its active state in 2003-2004. In this paper we discuss multi-frequency analysis of the inner jet (first 1 mas) kinematics. The unprecedentedly dense time sampling allows us to trace jet components without misidentification and to calculate the component speeds with good accuracy. In the smooth superluminal jet we were able to identify and track three components over time moving outwards with relatively high apparent superluminal speeds (8.5-19.4 $c$), which contradicts the hypothesis of a stationary oscillating jet in this source. Component ejections occur at a relatively high rate (once in two months), and they are accompanied by mm-continuum outbursts. Superluminal jet components move along wiggling trajectories, which is an indication of actual helical motion. Fast proper motion and rapid decay of the components suggest that this source should be observed with the VLBI at a rate of at least once in one or two months in order to trace superluminal jet components without confusion.Comment: 4 pages, 3 figures, Astronomy & Astrophysics Letter, language corrections adde

Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung

<p>Abstract</p> <p>Background</p> <p>Claudins are the main components of tight junctions, structures which are associated with cell polarity and permeability. The aim of this study was to analyze the expression of claudins 1, 3, 4, 5, and 7 in developing human lung tissues from 12 to 40 weeks of gestation.</p> <p>Methods</p> <p>47 cases were analyzed by immunohistochemisty for claudins 1, 3, 4, 5 and 7. 23 cases were also investigated by quantitative RT-PCR for claudin-1, -3 and -4.</p> <p>Results</p> <p>Claudin-1 was expressed in epithelium of bronchi and large bronchioles from week 12 onwards but it was not detected in epithelium of developing alveoli. Claudin-3, -4 and -7 were strongly expressed in bronchial epithelium from week 12 to week 40, and they were also expressed in alveoli from week 16 to week 40. Claudin-5 was expressed strongly during all periods in endothelial cells. It was expressed also in epithelium of bronchi from week 12 to week 40, and in alveoli during the canalicular period. RT-PCR analyses revealed detectable amounts of RNAs for claudins 1, 3 and 4 in all cases studied.</p> <p>Conclusion</p> <p>Claudin-1, -3, -4, -5, and -7 are expressed in developing human lung from week 12 to week 40 with distinct locations and in divergent quantities. The expression of claudin-1 was restricted to the bronchial epithelium, whereas claudin-3, -4 and -7 were positive also in alveolar epithelium as well as in the bronchial epithelium. All claudins studied are linked to the development of airways, whereas claudin-3, -4, -5 and -7, but not claudin-1, are involved in the development of acinus and the differentiation of alveolar epithelial cells.</p