The possible role of iodinated contrast in enhancing acute kidney injury in a critically ill neonate – a case report

Više modalitetni pristup neophodan je za postizanje točne dijagnoze u slučaju prirođenih srčanih grešaka prisutnih kod novorođen- četa. Napredak u medicinskim slikovnim metodama povećao je ovisnost o podacima dobivenim radiološkim pretragama. Među- tim, neke od tih pretraga zahtijevaju primjenu kontrasta, što može povećati rizik od kontrastom izazvanog akutnog oštećenja bubrega. Opisujemo slučaj novorođenčeta s transpozicijom velikih arterija, koje je izloženo iodiniranom kontrastu tijekom angio-tomografije. Nedugo nakon ovoga postupka kod novorođenčeta je nastupila anurija uz povišene razine ureje i kreatinina pa je dijagnosticirano akutno oštećenje bubrega izazvano kontrastom. Ubrzo potom dijete je umrlo usprkos primjeni peritonejske dijalize. Analiza provedena post mortem pokazala je proširenu koagulativnu nekrozu kortikalnih i medularnih slojeva bubrega.A multi-modality approach is necessary for accurate diagnosis in case of congenital heart diseases present in the neonatal period. Advances in medical imaging have increased dependence on the information provided by radiological studies. However, several of these studies require the use of contrast, which may enhance the risk of contrast-induced acute kidney injury. We report on a case of a neonate with transposition of great arteries who was submitted to iodinated contrast during angiotomography. Soon after the procedure, he presented anuria and increased urea and creatinine levels, and was diagnosed with a contrast-induced acute kidney injury. Despite the use of peritoneal dialysis, he died soon thereafter. Post mortem analysis showed extensive coagulative necrosis in the renal cortical and medullary layers

Cellular effects of an aqueous solution of Losartan® on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte

Photograph of a scene on the Lake Hefner Trails