Evaluating 'Prefer not to say' Around Sensitive Disclosures

As people's offline and online lives become increasingly entwined, the sensitivity of personal information disclosed online is increasing. Disclosures often occur through structured disclosure fields (e.g., drop-down lists). Prior research suggests these fields may limit privacy, with non-disclosing users being presumed to be hiding undesirable information. We investigated this around HIV status disclosure in online dating apps used by men who have sex with men. Our online study asked participants (N=183) to rate profiles where HIV status was either disclosed or undisclosed. We tested three designs for displaying undisclosed fields. Visibility of undisclosed fields had a significant effect on the way profiles were rated, and other profile information (e.g., ethnicity) could affect inferences that develop around undisclosed information. Our research highlights complexities around designing for non-disclosure and questions the voluntary nature of these fields. Further work is outlined to ensure disclosure control is appropriately implemented around online sensitive information disclosures

Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship

OBJECTIVES: The Prostate Imaging Quality (PI-QUAL) score is a new metric to evaluate the diagnostic quality of multiparametric magnetic resonance imaging (MRI) of the prostate. This study assesses the impact of an intervention, namely a prostate MRI quality training lecture, on the participant's ability to apply PI-QUAL. METHODS: Sixteen participants (radiologists, urologists, physicists, and computer scientists) of varying experience in reviewing diagnostic prostate MRI all assessed the image quality of ten examinations from different vendors and machines. Then, they attended a dedicated lecture followed by a hands-on workshop on MRI quality assessment using the PI-QUAL score. Five scans assessed by the participants were evaluated in the workshop using the PI-QUAL score for teaching purposes. After the course, the same participants evaluated the image quality of a new set of ten scans applying the PI-QUAL score. Results were assessed using receiver operating characteristic analysis. The reference standard was the PI-QUAL score assessed by one of the developers of PI-QUAL. RESULTS: There was a significant improvement in average area under the curve for the evaluation of image quality from baseline (0.59 [95 % confidence intervals: 0.50-0.66]) to post-teaching (0.96 [0.92-0.98]), an improvement of 0.37 [0.21-0.41] (p < 0.001). CONCLUSIONS: A teaching course (dedicated lecture + hands-on workshop) on PI-QUAL significantly improved the application of this scoring system to assess the quality of prostate MRI examinations. KEY POINTS: • A significant improvement in the application of PI-QUAL for the assessment of prostate MR image quality was observed after an educational intervention. • Appropriate training on image quality can be delivered to those involved in the acquisition and interpretation of prostate MRI. • Further investigation will be needed to understand the impact on improving the acquisition of high-quality diagnostic prostate MR examinations

SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research

International audienceDiffusion magnetic resonance imaging (dMRI) is the only non-invasive method for mapping white matter connections in the brain. We describe SlicerDMRI, a software suite that enables visualization and analysis of dMRI for neuroscientific studies and patient-specific anatomical assessment. SlicerDMRI has been successfully applied in multiple studies of the human brain in health and disease, and here we especially focus on its cancer research applications. As an extension module of the 3D Slicer medical image computing platform, the SlicerDMRI suite enables dMRI analysis in a clinically relevant multimodal imaging workflow. Core SlicerDMRI functionality includes diffusion tensor estimation, white matter tractography with single and multi-fiber models, and dMRI quantification. SlicerDMRI supports clinical DICOM and research file formats, is open-source and cross-platform, and can be installed as an extension to 3D Slicer (www.slicer.org). More information, videos, tutorials, and sample data are available at dmri.slicer.org

Student Compostiton Recital

Kennesaw State University School of Music presents Student Composition Recital.https://digitalcommons.kennesaw.edu/musicprograms/1390/thumbnail.jp

QED+QCD Corrections to the Anomalous Magnetic Moment of the Muon

The current 3:7 discrepancy between experimental and Standard Model determinations of the anomalous magnetic moment has long stood without resolution. This serves as an important test for the Standard Model of particle physics, which is the best theory we have to describe the universe at a subatomic scale. If this discrepancy can be removed though an increase of the precision of the experimental results and Standard Model calculations, we will have another important constraint on the Standard Model. On the other hand, if this discrepancy is increased we will have important evidence of new physics effects, beyond our current understanding. Either resolution will be of great impact for the physics community. The large majority of the Standard Model uncertainty comes from hadronic contributions. In this thesis we investigate improvements to the leading order hadronic contribution using a technique called lattice gauge theory. In particular, we will look at the inclusion of QED corrections to the leading order hadronic contribution using fully dynamical QCD+QED gauge eld ensembles generated by the QCDSF collaboration. This investigation is undertaken using two lattice volumes, with three sets of sub-ensembles on each volume. In order to extrapolate the results to the physical quark mass we also use a range of partially quenched quark masses, corresponding to pion masses ranging from 230 MeV to 790 MeV. From this study we find the QED corrections to be 0:2% 0:1%. While small, this is in no way insignificant. Current lattice studies aim for a precision greater than 0:5%, making the QED corrections of great importance in meeting that goal. We also present an exploratory investigation into the QED corrections to the leading order disconnected contribution. This is done at the SU(3) symmetric point using a single lattice volume. We find a QED correction of O(0:5%).Thesis (Ph.D.) -- University of Adelaide, School of Physical Sciences, 202

Anomalous magnetic moment of the muon with dynamical QCD+QED

There exists a long standing discrepancy of around 3.5σ between experimental measurements and standard model calculations of the magnetic moment of the muon. Current experiments aim to reduce the experimental uncertainty by a factor of 4, and Standard Model calculations must also be improved by a similar factor. The largest uncertainty in the Standard Model calculation comes from the QCD contribution, in particular the leading order hadronic vacuum polarisation (HVP). To calculate the HVP contribution, we use lattice gauge theory, which allows us to study QCD at low energies. In order to better understand this quantity, we investigate the effect of QED corrections to the leading order HVP term by including QED in our lattice calculations, and investigate flavour breaking effects. This is done using fully dynamical QCD+QED gauge configurations generated by the QCDSF collaboration and a novel method of quark tuning

Anomalous magnetic moment of the muon with dynamical QCD+QED

The current $3.5\sigma$ discrepancy between experimental and Standard Model determinations of the anomalous magnetic moment of the muon $a_\mu=(g-2)/2$ can only be extended to the discovery $5\sigma$ regime through a reduction of both experimental and theoretical uncertainties. On the theory side, this means a determination of the hadronic vacuum polarisation (HVP) contribution to better than 0.5%, a level of precision that demands the inclusion of QCD + QED effects to properly understand how the behaviour of quarks are modified when their electric charges are turned on. The QCDSF collaboration has generated an ensemble of configurations with dynamical QCD and QED fields with the specific aim of studying flavour breaking effects arising from differences in the quark masses and charges in physical quantities. Here we study these effects in a calculation of HVP around the SU(3) symmetric point. Furthermore, by performing partially-quenched simulations we are able to cover a larger range of quark masses and charges on these configurations and then fit the results to an SU(3) flavour breaking expansion. Subsequently, this allows for an extrapolation to the physical point

Anomalous magnetic moment of the muon with dynamical QCD plus QED

There exists a long standing discrepancy of around 3.5σ between experimental measurements and standard model calculations of the magnetic moment of the muon. Current experiments aim to reduce the experimental uncertainty by a factor of 4, and Standard Model calculations must also be improved by a similar factor. The largest uncertainty in the Standard Model calculation comes from the QCD contribution, in particular the leading order hadronic vacuum polarisation (HVP). To calculate the HVP contribution, we use lattice gauge theory, which allows us to study QCD at low energies. In order to better understand this quantity, we investigate the effect of QED corrections to the leading order HVP term by including QED in our lattice calculations, and investigate flavour breaking effects. This is done using fully dynamical QCD+QED gauge configurations generated by the QCDSF collaboration and a novel method of quark tuning.Alex Westin, Waseem Kamleh, Ross Young, James Zanotti, Roger Horsley, Yoshifumi Nakamura, Holger Perlt, Paul Rakow, Gerrit Schierholz and Hinnerk Stübe

Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer.

Despite advances in detection and therapy, castration-resistant prostate cancer continues to be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation by the Androgen Receptor (AR), has the potential to provide insight into novel mechanisms and pathways to prevent and treat advanced, castrate-resistant prostate cancers. To this end, we investigated the role of the embryonic stem cell regulator Sox2 [SRY (sex determining region Y)-box 2] in normal and malignant prostate epithelial cells. In the normal prostate, Sox2 is expressed in a portion of basal epithelial cells. Prostate tumors were either Sox2-positive or Sox2-negative, with the percentage of Sox2-positive tumors increasing with Gleason Score and metastases. In the castration-resistant prostate cancer cell line CWR-R1, endogenous expression of Sox2 was repressed by AR signaling, and AR chromatin-IP shows that AR binds the enhancer element within the Sox2 promoter. Likewise, in normal prostate epithelial cells and human embryonic stem cells, increased AR signaling also decreases Sox2 expression. Resistance to the anti-androgen MDV3100 results in a marked increase in Sox2 expression within three prostate cancer cell lines, and in the castration-sensitive LAPC-4 prostate cancer cell line ectopic expression of Sox2 was sufficient to promote castration-resistant tumor formation. Loss of Sox2 expression in the castration-resistant CWR-R1 prostate cancer cell line inhibited cell growth. Up-regulation of Sox2 was not associated with increased CD133 expression but was associated with increased FGF5 (Fibroblast Growth Factor 5) expression. These data propose a model of elevated Sox2 expression due to loss of AR-mediated repression during castration, and consequent castration-resistance via mechanisms not involving induction of canonical embryonic stem cell pathways

Sox2 Is an Androgen Receptor-Repressed Gene That Promotes Castration-Resistant Prostate Cancer

Despite advances in detection and therapy, castration-resistant prostate cancer continues to be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation by the Androgen Receptor (AR), has the potential to provide insight into novel mechanisms and pathways to prevent and treat advanced, castrate-resistant prostate cancers. To this end, we investigated the role of the embryonic stem cell regulator Sox2 [SRY (sex determining region Y)-box 2] in normal and malignant prostate epithelial cells. In the normal prostate, Sox2 is expressed in a portion of basal epithelial cells. Prostate tumors were either Sox2-positive or Sox2-negative, with the percentage of Sox2-positive tumors increasing with Gleason Score and metastases. In the castration-resistant prostate cancer cell line CWR-R1, endogenous expression of Sox2 was repressed by AR signaling, and AR chromatin-IP shows that AR binds the enhancer element within the Sox2 promoter. Likewise, in normal prostate epithelial cells and human embryonic stem cells, increased AR signaling also decreases Sox2 expression. Resistance to the anti-androgen MDV3100 results in a marked increase in Sox2 expression within three prostate cancer cell lines, and in the castration-sensitive LAPC-4 prostate cancer cell line ectopic expression of Sox2 was sufficient to promote castration-resistant tumor formation. Loss of Sox2 expression in the castration-resistant CWR-R1 prostate cancer cell line inhibited cell growth. Up-regulation of Sox2 was not associated with increased CD133 expression but was associated with increased FGF5 (Fibroblast Growth Factor 5) expression. These data propose a model of elevated Sox2 expression due to loss of AR-mediated repression during castration, and consequent castration-resistance via mechanisms not involving induction of canonical embryonic stem cell pathways.</p