Minimizing the Dick Effect in an Optical Lattice Clock

We discuss the minimization of the Dick effect in an optical lattice clock. We show that optimizing the time sequence of operation of the clock can lead to a significant reduction of the clock stability degradation by the frequency noise of the interrogation laser. By using a non-destructive detection of the atoms, we are able to recycle most of the atoms between cycles and consequently to strongly reduce the time spent capturing the atoms in each cycle. With optimized parameters, we expect a fractional Allan deviation better than 2E-16$\tau^{-1/2}$ for the lattice clock.Comment: 6 pages, 10 figures. Submitted to IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Contro

The Laser of the ALICE Time Projection Chamber

The large TPC ($95 \mathrm{m}^3$) of the ALICE detector at the CERN LHC was commissioned in summer 2006. The first tracks were observed both from the cosmic ray muons and from the laser rays injected into the TPC. In this article the basic principles of operating the $266 \mathrm{nm}$ lasers are presented, showing the installation and adjustment of the optical system and describing the control system. To generate the laser tracks, a wide laser beam is split into several hundred narrow beams by fixed micro-mirrors at stable and known positions throughout the TPC. In the drift volume, these narrow beams generate straight tracks at many angles. Here we describe the generation of the first tracks and compare them with simulations.Comment: QM06 poster proceedings, 6 pages, 4 figure

Ultrastable lasers based on vibration insensitive cavities

We present two ultra-stable lasers based on two vibration insensitive cavity designs, one with vertical optical axis geometry, the other horizontal. Ultra-stable cavities are constructed with fused silica mirror substrates, shown to decrease the thermal noise limit, in order to improve the frequency stability over previous designs. Vibration sensitivity components measured are equal to or better than 1.5e-11 per m.s^-2 for each spatial direction, which shows significant improvement over previous studies. We have tested the very low dependence on the position of the cavity support points, in order to establish that our designs eliminate the need for fine tuning to achieve extremely low vibration sensitivity. Relative frequency measurements show that at least one of the stabilized lasers has a stability better than 5.6e-16 at 1 second, which is the best result obtained for this length of cavity.Comment: 8 pages 12 figure

Experimenting an optical second with strontium lattice clocks

Progress in realizing the SI second had multiple technological impacts and enabled to further constraint theoretical models in fundamental physics. Caesium microwave fountains, realizing best the second according to its current definition with a relative uncertainty of 2-4x10^(-16), have already been superseded by atomic clocks referenced to an optical transition, both more stable and more accurate. Are we ready for a new definition of the second? Here we present an important step in this direction: our system of five clocks connects with an unprecedented consistency the optical and the microwave worlds. For the first time, two state-of-the-art strontium optical lattice clocks are proven to agree within their accuracy budget, with a total uncertainty of 1.6x10^(-16). Their comparison with three independent caesium fountains shows a degree of reproducibility henceforth solely limited at the level of 3.1x10^(-16) by the best realizations of the microwave-defined second.Comment: 9 pages, 4 figures, 2 table

Construct validity of the Dissociative Experiences Scale (DES): I. The relationship between the DES and other self-report measures of DES

p. 185-188The present study attempted to expand the construct validity of the Dissociative Experiences Scale (DES) by comparing it to: (a) other self-report measures of dissociation (e.g., the Tellegen Absorption Scale [TAS] and the Perceptual Alteration Scale [PAS]); (b) the construct of "ambiguity intolerance" (assessed by the Yellen Ambiguity Intolerance Scale [YAIS]); and (c) the Jenkins Activity Schedule (JAS: which measures the degree of Type A behavior). Three hundred and eleven undergraduates participated in an experiment on "Hypnotizability and Personality, " and filled out the DES TAS, PAS, YAIS, and JAS. The DES total score (and three DES factor scores) correlated with the TAS and PAS in the range of .24 - .52 (all correlations were significant at the .001 level, two-tailed). Furthermore, the DES total score (and the three DES factor scores) correlated significantly with the YAIS overall score (r's ranged from .22 - .24, all p's < .001), but did not correlate significantly with the JAS (r's ranged from -.03 - .04, ns). The findings suggest that DES scores (i.e., total scores and each of the three DES factor scores) show good levels of convergent validity as they correlate significantly with other self-report measures of dissociation. However, the intercorrelations were not high enough to consider the different dissociation measures as interchangeable. Furthermore, subjects reporting high levels of dissociative experiences also reported higher levels of ambiguity intolerance. However, no significant association was observed between DES scores and the Type A behavior pattern

Consumption caught in the cash nexus.

During the last thirty years, ‘consumption’ has become a major topic in the study of contemporary culture within anthropology, psychology and sociology. For many authors it has become central to understanding the nature of material culture in the modern world but this paper argues that the concept is, in British writing at least, too concerned with its economic origins in the selling and buying of consumer goods or commodities. It is argued that to understand material culture as determined through the monetary exchange for things - the cash nexus - leads to an inadequate sociological understanding of the social relations with objects. The work of Jean Baudrillard is used both to critique the concept of consumption as it leads to a focus on advertising, choice, money and shopping and to point to a more sociologically adequate approach to material culture that explores objects in a system of models and series, ‘atmosphere’, functionality, biography, interaction and mediation

Plant closures, precariousness and policy responses:revisiting MG Rover 10 years on

With automotive plants being closed in Australia and western Europe, this article reflects on the employment status of ex-MG Rover (MGR) workers following the closure of the Longbridge plant in 2005. In particular, it draws on Standing's typology of labour market insecurity and uses a mixed-methods approach including an analysis of a longitudinal survey of some 200 ex-MGR workers, and in-depth interviews with ex-workers and policy-makers. While the policy response to the closure saw significant successes in terms of the great majority of workers successfully adjusting into re-employment, and with positive findings in terms of re-training and education, the paper finds significant challenges in terms of security of employment, income, job quality and representation at work years after closure. In particular, the paper posits that the general lack of attention to employment security at the macrolevel effectively undermined elements of a positive policy response over the longer run. This in turn suggests longer-term policy measures are required to address aspects of precariousness at work

Seven days treatment with the angiotensin II type 2 receptor agonist C21 in hospitalized COVID-19 patients; a placebo-controlled randomised multi-centre double-blind phase 2 trial

Background: COVID-19 morbidity and mortality remains high and the need for safe and effective drugs continues despite vaccines. Methods: Double-blind, placebo-controlled, multi-centre, randomised, parallel group phase 2 trial to evaluate safety and efficacy of oral angiotensin II type 2 receptor agonist C21 in hospitalized patients with COVID-19 and CRP ≥ 50-150 mg/L conducted at eight sites in India (NCT04452435). Patients were randomly assigned 100 mg C21 bid or placebo for 7 days in addition to standard of care. Primary endpoint: reduction in CRP. The study period was 21 July to 13 October 2020. Findings: 106 patients were randomised and included in the analysis (51 C21, 55 placebo). There was no significant group difference in reduction of CRP, 81% and 78% in the C21 and placebo groups, respectively, with a treatment effect ratio of 0.85 [90% CI 0.57, 1.26]. In a secondary analysis in patients requiring supplemental oxygen at randomisation, CRP was reduced in the C21 group compared to placebo. At the end of the 7-day treatment, 37 (72.5%) and 30 (54.5%) of the patients did not require supplemental oxygen in the C21 and placebo group, respectively (OR 2.20 [90% CI 1.12, 4.41]). A post hoc analysis showed that at day 14, the proportion of patients not requiring supplemental oxygen was 98% and 80% in the C21 group compared to placebo (OR 12.5 [90% CI 2.9, 126]). Fewer patients required mechanical ventilation (one C21 patient; four placebo patients), and C21 was associated with a numerical reduction in the mortality rate (one vs three in the C21 and placebo group, respectively). Treatment with C21 was safe and well tolerated. Interpretation: Among hospitalised patients with COVID-19 receiving C21 for 7 days there was no reduction in CRP compared to placebo. However, a post-hoc analysis indicated a marked reduction of requirement for oxygen at day 14. The day 14 results from this study justify further evaluation in a Phase 3 study and such a trial is currently underway. Funding: Vicore Pharma AB and LifeArc, UK

Anti-Nirvana: crime, culture and instrumentalism in the age of insecurity

‘Anti-Nirvana’ explores the relationship between consumer culture, media and criminal motivations. It has appeared consistently on the list of the top-ten most-read articles in this award-winning international journal, and it mounts a serious neo-Freudian challenge to the predominant naturalistic notion of ‘resistance’ at the heart of liberal criminology and media studies. It is also cited in the Oxford Handbook of Criminology and other criminology texts as a persuasive argument in support of the theory that criminality amongst young people is strongly linked to the acquisitive values of consumerism and the images of possessive individualism that dominate mass media

The APEX framework: prototyping of ubiquitous environments based on Petri Nets

The user experience of ubiquitous environments is a determining factor in their success. The characteristics of such systems must be explored as early as possible to anticipate potential user problems, and to reduce the cost of redesign. However, the development of early prototypes to be evaluated in the target environment can be disruptive to the ongoing system and therefore unacceptable. This paper reports on an ongoing effort to explore how model-based rapid prototyping of ubiquitous environments might be used to avoid actual deployment while still enabling users to interact with a representation of the system. The paper describes APEX, a framework that brings together an existing 3D Application Server with CPN Tools. APEX-based prototypes enable users to navigate a virtual world simulation of the envisaged ubiquitous environment. The APEX architecture and the proposed CPN-based modelling approach are described. An example illustrates their use.Fundação para a Ciência e a Tecnologia (FCT) - bolsa de doutoramento SFRH/BD/41179/200