GP prescribing of nicotine replacement and bupropion to aid smoking cessation in England and Wales

Aims Prescribing nicotine replacement therapy (NRT) or bupropion for smoking cessation is of considerable importance to public health but little is known about prescribing practices. This paper examines general practitioners' (GPs') prescribing patterns in Britain where these drugs are reimbursed. The results have implications for other health-care systems considering introducing reimbursement.Design, participants and setting Postal survey conducted in 2002 of a random sample of 1088 GPs in England and Wales, of whom 642 (59%) responded.Measures Number of requests GPs reported having received from patients for NRT and bupropion over the past month, the number of prescriptions they reported issuing and ratings of attitudes to these medications.Findings GPs reported receiving an average of 4.3 requests for NRT and 1.9 for bupropion in the previous month. They reported issuing 3.5 prescriptions for NRT and 1.2 for bupropion. Almost all GPs accepted that NRT (95%) and bupropion (97%) should be reimbursable on National Health Service (NHS) prescription. However, a significant minority of those who received requests for prescriptions did not issue any (81% for NRT and 26% for bupropion). This was related to whether they thought these products should be available on NHS prescription for both NRT and bupropion (OR = 0.66, P < 0.05), which in turn was related to beliefs about whether smokers should have to pay for treatment themselves, the cost-effectiveness of NRT/bupropion and the low priority they would give NRT/bupropion in the drug budget. For bupropion, concern about side-effects independently predicted not prescribing [odds ratio (OR) = 1.46, P < 0.03].Conclusion In the British health-care system, which has a well-established system for technology assessment and professionally endorsed guidelines, a significant minority of GPs decline all patient requests for stop-smoking medicines

Standard and Non-standard Extensions of Lie algebras

We study the problem of quadruple extensions of simple Lie algebras. We find that, adding a new simple root $\alpha_{+4}$, it is not possible to have an extended Kac-Moody algebra described by a Dynkin-Kac diagram with simple links and no loops between the dots, while it is possible if $\alpha_{+4}$ is a Borcherds imaginary simple root. We also comment on the root lattices of these new algebras. The folding procedure is applied to the simply-laced triple extended Lie algebras, obtaining all the non-simply laced ones. Non- standard extension procedures for a class of Lie algebras are proposed. It is shown that the 2-extensions of $E_{8}$, with a dot simply linked to the Dynkin-Kac diagram of $E_{9}$, are rank 10 subalgebras of $E_{10}$. Finally the simple root systems of a set of rank 11 subalgebras of $E_{11}$, containing as sub-algebra $E_{10}$, are explicitly written.Comment: Revised version. Inaccurate statements corrected. Expanded version with added reference

Tracking in a space variant active vision system

Without the ability to foveate on and maintain foveation, active vision for applications such as surveillance, object recognition and object tracking are difficult to build. Although foveation in cartesian coordinates is being actively pursued by many, multi-resolution high accuracy foveation in log polar space has not been given much attention. This paper addresses the use of foveation to track a single object as well as multiple objects for a simulated space variant active vision system. Complex logarithmic mapping is chosen firstly because it provides high resolution and wide angle viewing. Secondly, the spatially variant structure of log polar space leads to an object increasing in size as it moves towards the fovea. This is important as we know which object is closer to the fovea at any instant in time.<br /

Resistively-Detected NMR in a Two-Dimensional Electron System near ν=1\nu = 1: Clues to the Origin of the Dispersive Lineshape

Resistively-detected NMR measurements on 2D electron systems near the $\nu = 1$ quantum Hall state are reported. In contrast to recent results of Gervais \emph{et al.} [Phys. Rev. Lett. $\bf 94$, 196803 (2005)], a dispersive lineshape is found at all RF powers studied and Korringa-like nuclear spin-lattice relaxation is observed. The shape of the unexplained dispersive lineshape is found to invert when the temperature derivative of the longitudinal resistance changes sign. This suggests that both Zeeman and thermal effects are important to resistively-detected NMR in this regime.Comment: 5 pages, 4 figures. Version accepted for publication in Phys. Rev.B, Rapid Communication