Detection and localization of early- and late-stage cancers using platelet RNA

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I–IV cancer patients and in half of 352 stage I–III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening

A new wireless underground network system for continuous monitoring of soil water contents

A new stand-alone wireless embedded network system has been developed recently for continuous monitoring of soil water contents at multiple depths. This paper presents information on the technical aspects of the system, including the applied sensor technology, the wireless communication protocols, the gateway station for data collection, and data transfer to an end user Web page for disseminating results to targeted audiences. Results from the first test of the network system are presented and discussed, including lessons learned so far and actions to be undertaken in the near future to improve and enhance the operability of this innovative measurement approach

IMIS-Beiträge Heft 12 - Themenheft: Eingliederung und Ausgrenzung. Beiträge aus der Historischen Migrationsforschung

J. Oltmer: Einführung M. Mörner: Seventeenth-Century Immigration in Sweden W. D. Kamphoefner: Deutsch-Amerikaner: Musterknaben der Einwanderung" S. Hochstadt: Vertreibung aus Deutschland und Überleben in Shanghai: jüdische NS-Vertriebene in China H.-A. Persson: Settling the Peace, the Cold War, and the Ethnic Cleansing of the Germans from Central and Eastern Europe A. Liucija Arbusauskaité: The Soviet Policy Towards the "Kaliningrad Germans" 1945-1951 H. L. Wesseling: Migration and Decolonization: the Case of the Netherlands M. Bommes: Zweites DFG-Graduiertenkolleg "Migration im modernen Europa" am IMIS eröffnet H.-J. Hoffmann-Nowotny: Aspekte der internationalen Migratio

Detection and localization of early- and late-stage cancers using platelet RNA

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening