(13) Proposal to designate reproductively competent species of hybrid origin by an × placed in brackets (reword Article H.3 Note 1)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149747/1/tax01103.pd

Patterns of Genetic Variation in Southern Appalachian Populations of Athyrium filix‐femina var. asplenioides (Dryopteridaceae)

Allozyme variation (17 loci coding 11 enzymes) was investigated in 14 populations of the fern Athyrium filix‐femina var. asplenioides arrayed at differing elevations and latitudes in the southern Appalachians. Allozyme fingerprints showed that asplenioides individuals comprise meandering, overlapping clones usually ≤3 m in extent, occasionally forming larger clones of up to 17 m. Levels of genetic variability in populations (means: , , ) were near the averages for both ferns and seed plants. General conformance to Hardy‐Weinberg expectations indicated a predominantly outcrossing mating system. Hierarchical F statistic analysis and occasional deficits and excesses of heterozygotes indicated population substructure. Similar allele frequencies across all populations resulted in low to moderate values (mean ; ) and high values of genetic similarity (mean ; mean ). Hierarchical analysis indicated that neither regional proximity ( ) nor elevation ( ) contributed substantially to divergence among populations ( ), a result corroborated by UPGMA analysis that clustered together populations from different regions and of different elevational class. Southern Appalachian asplenioides differed from more eastern asplenioides populations of the piedmont and coastal plain in having higher frequencies of Pgm‐2c and Tpi‐2B, alleles characteristic of the more northern variety angustum. Nonetheless, genetic distinctness of the two varieties was maintained. We hypothesize that higher frequencies of angustum alleles in the southern Appalachian asplenioides populations are the result of introgression from angustum that persisted at high elevations as both taxa migrated northward following the retreat of the Wisconsinan glacier

2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects

Objective. The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM. Methods. Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consensus gold-standard ratings of minimal, moderate and major improvement. Experts completed a survey regarding clinically meaningful improvement in the core set measures (CSM) and a conjoint-analysis survey (using 1000Minds software) to derive relative weights of CSM and candidate definitions. Six types of candidate definitions for response criteria were derived using survey results, logistic regression, conjoint analysis, application of conjoint-analysis weights to CSM and published definitions. Sensitivity, specificity and area under the curve were defined for candidate criteria using consensus patient profile data, and selected definitions were validated using clinical trial data. Results. Myositis specialists defined the degree of clinically meaningful improvement in CSM for minimal, moderate and major improvement. The conjoint-analysis survey established the relative weights of CSM, with muscle strength and Physician Global Activity as most important. Many candidate definitions showed excellent sensitivity, specificity and area under the curve in the consensus profiles. Trial validation showed that a number of candidate criteria differentiated between treatment groups. Top candidate criteria definitions were presented at the consensus conference. Conclusion. Consensus methodology, with definitions tested on patient profiles and validated using clinical trials, led to 18 definitions for adult PM/DM and 14 for JDM as excellent candidates for consideration in the final consensus on new response criteria for myositis

EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting

This report covers the topics of discussion and the recommendations of the panel members. On December 8 and 9, 2010, the Geochemistry, Biogeochemistry, and Subsurface Science (GBSS) Science Theme Advisory Panel (STAP) convened for a more in-depth exploration of the five Science Theme focus areas developed at a similar meeting held in 2009. The goal for the fiscal year (FY) 2011 meeting was to identify potential topical areas for science campaigns, necessary experimental development needs, and scientific members for potential research teams. After a review of the current science in each of the five focus areas, the 2010 STAP discussions successfully led to the identification of one well focused campaign idea in pore-scale modeling and five longer-term potential research campaign ideas that would likely require additional workshops to identify specific research thrusts. These five campaign areas can be grouped into two categories: (1) the application of advanced high-resolution, high mass accuracy experimental techniques to elucidate the interplay between geochemistry and microbial communities in terrestrial ecosystems and (2) coupled computation/experimental investigations of the electron transfer reactions either between mineral surfaces and outer membranes of microbial cells or between the outer and inner membranes of microbial cells

EMSL Pore Scale Modeling Challenge/Workshop

Report covers the background for the workshop, objectives, important research directions, necessary capabilities and overall recommendations

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Interpopulational Comparison of Dose-Mediated Antheridiogen Response in Onoclea sensibilis

Volume: 89Start Page: 221End Page: 23

Osmunda cinnamomea forma frondosa at Mountain Lake, Virginia

Volume: 75Start Page: 128End Page: 13