69 research outputs found
Effect of ACE inhibitors on endothelial dysfunction: Unanswered questions and implications for further investigation and therapy
Experimental studies have suggested that angiotensin-converting enzyme (ACE) inhibitors may have an important role in blocking the progression of and/or reversing endothelial dysfunction. The extrapolation of these experimental studies to the clinical situation has, however, been disappointing. Studies of forearm-mediated endothelial vasodilatation in patients with hypertension with captopril, enalapril, and cilazapril have been negative. The finding of the Trial in Reversing Endothelial Dysfunction (TREND) that the administration of quinapril to normotensive patients with coronary artery disease in part restores endothelial-mediated coronary vasodilation, as assessed by intracoronary administration of acetylcholine, has important implications for future therapy and raises several important questions. The differences in the TREND and previous studies of ACE inhibitors on endothelial dysfunction may be due to mechanistic differences in endothelial dysfunction in patients with coronary artery disease and hypertension. Although in general there has been a good correlation between endothelial dysfunction as assessed by forearm flow and coronary endothelial dysfunction as assessed by acetylcholine, these vascular beds may be affected differently by therapeutic interventions, especially with an ACE inhibitor, which may affect sheart stress and angiotensin II formation in different vascular beds differently. Third, one needs to question whether the effect of quinapril on coronary endothelial dysfunction is a class effect or unique to quinapril. It will be necessary to test the effectiveness of other ACE inhibitors on coronary endothelial dysfunction in humans before concluding that the beneficial effects of quinapril are due to a class effect.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44542/1/10557_2004_Article_BF00051113.pd
A High-Performance Liquid Chromatographic Method for the Determination of Hypoxanthine, Xanthine, Uric Acid and Allantoin in Serum
A Comparative Study of the Concentrations of Hypoxanthine, Xanthine, Uric Acid and Allantoin in the Peripheral Blood of Normals and Patients with Acute Myocardial Infarction and Other Ischaemic Diseases
Left ventricular ejection fraction may not be useful as an end point of thrombolytic therapy comparative trials.
Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants: Can caffeic acid phenethyl ester (CAPE) protect the heart?
Free Radicals in Hypothermic Rat Heart Preservation — Prevention of Damage by Mannitol and Desferrioxamine
Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: Pharmacological interventions
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