Opposites Do Not Attract: The Impact of Domestic Institutions, Power, and Prior Commitments on Alignment Choices

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146950/1/0020-8833.00055.pd

Shared Decision-Making as Experienced by Rehabilitation Students on an International Service-Learning Trip: A Phenomenological Investigation

The value of service-learning has been well documented in medical and allied health education (Abedini, Gruppen, Kolars, & Kumagai, 2012; Ekelman, Dal Bello-Haas, Bazyk, & Bazyk, 2003; Pechak, Gonzalez, Summers, & Capshaw, 2013; Pechak & Thompson, 2009; Ryan-Krause, 2016). Several studies have been conducted looking at cultural experiences and clinical reasoning (Corbett & Fickert, 2009; Sheppard & Landry, 2015; Nouvet, Chan & Schwartz, 2016). What has not been well-examined though is the concept of shared decision-making by those engaged in service-learning. The purpose of this phenomenological investigation (i.e. study) was to identify how occupational therapy (OT) and physical therapy (PT) students defined shared decision-making in the context of an international service-learning trip to Guatemala City, Guatemala in April 2017

Vortices within vortices: hierarchical nature of vortex tubes in turbulence

The JHU turbulence database [1] can be used with a state of the art visualisation tool [2] to generate high quality fluid dynamics videos. In this work we investigate the classical idea that smaller structures in turbulent flows, while engaged in their own internal dynamics, are advected by the larger structures. They are not advected undistorted, however. We see instead that the small scale structures are sheared and twisted by the larger scales. This illuminates the basic mechanisms of the turbulent cascade.Comment: 2 pages, 1 low quality video, 1 high quality vide

Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II

The Rpb4 and Rpb7 subunits of eukaryotic RNA polymerase II (RNAP(II)) form a heterodimer that protrudes from the 10-subunit core of the enzyme. We have obtained crystals of the human Rpb4/Rpb7 heterodimer and determined the structure to 2.7 Å resolution. The presence of putative RNA-binding domains on the Rpb7 subunit and the position of the heterodimer close to the RNA exit groove in the 12 subunit yeast polymerase complex strongly suggests a role for the heterodimer in binding and stabilizing the nascent RNA transcript. We have complemented the structural analysis with biochemical studies directed at dissecting the RNA-binding properties of the human Rpb4/Rpb7 complex and that of the homologous E/F complex from Methanocaldococcus jannaschii. A number of conserved, solvent-exposed residues in both the human Rpb7 subunit and the archaeal E subunit have been modified by site-directed mutagenesis and the mutants tested for RNA binding by performing electrophoretic mobility shift assays. These studies have identified an elongated surface region on the corresponding face of both subunit E and Rpb7 that is involved in RNA binding. The area spans the nucleic acid binding face of the OB fold, including the B4–B5 loop, but also extends towards the N-terminal domain

Justice in climate policy:Distributing climate costs fairly

This open access book is looking into ways to achieve just climate policy within a country. The authors of this monograph share a unique, timely and original vision: continuous support for climate policy is more likely to emerge when citizens find that the distribution of the bill for climate costs is fair. But what is a fair distribution of climate costs? This is an important question because financial costs of mitigation (reducing greenhouse gases), adaptation (adapting to climate change) and damage (compensating or compensating after weather extremes) increase significantly in the coming decades. Drawing on philosophy and ethics, the authors propose ten principles for achieving just distributions of domestic climate costs. Examples of such principles are individual responsibility, the polluter pays, greatest utility and capacity to pay. Yet what a fair distribution is, depends on, for example, political preferences and the policy issue at hand. Empirical research on designing climate policies, however, shows that distributive principles are not part of the political, policy, and public discussions. The authors therefore argue that explicit attention to principles of just distribution at the start of a policy process contributes to support for climate policy. This book provides tools to professionals and students to achieve justice in climate policy

Simian varicella virus infects enteric neurons and α4β7 integrin-expressing gut-tropic T-cells in nonhuman primates

The pathogenesis of enteric zoster, a rare debilitating complication of reactivation of latent varicella-zoster virus (VZV) in the enteric nervous system (ENS), is largely unknown. Infection of monkeys with the closely related Varicellovirus simian varicella virus (SVV) mimics VZV disease in humans. In this study, we determined the applicability of the SVV nonhuman primate model to study Varicellovirus infection of the ENS. We confirmed VZV infection of the gut in latently infected adults and demonstrated th

Pathogenesis of tendinopathies: inflammation or degeneration?

The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether inflammation or degeneration has the prominent role is still a matter of debate. Assuming that there is a continuum from physiology to pathology, overuse may be considered as the initial disease factor; in this context, microruptures of tendon fibers occur and several molecules are expressed, some of which promote the healing process, while others, including inflammatory cytokines, act as disease mediators. Neural in-growth that accompanies the neovessels explains the occurrence of pain and triggers neurogenic-mediated inflammation. It is conceivable that inflammation and degeneration are not mutually exclusive, but work together in the pathogenesis of tendinopathies