360 research outputs found
High Power Solid State Retrofit Lamp Thermal Characterization and Modeling
Thermal and thermo-mechanical modeling and characterization of solid state lightening (SSL) retrofit LED lamp are presented in this paper. Paramount importance is to design SSL lamps for reliability, in which thermal and thermo-mechanical aspects are key points. The main goal is to get a precise 3D thermal lamp model for further thermal optimization. Simulations are performed with ANSYS and CoventorWare software tools to compere different simulation approaches. Simulated thermal distribution has been validated with thermal measurement on a commercial 8W LED lamp. Materials parametric study has been carried out to discover problematic parts for heat transfer from power LEDs to ambient and future solutions are proposed. The objectives are to predict the thermal management by simulation of LED lamp, get more understanding in the effect of lamp shape and used materials in order to design more effective LED lamps and predict light quality, life time and reliability
Coupled water, charge and salt transport in heterogeneous nano-fluidic systems
We theoretically study the electrokinetic transport properties of
nano-fluidic devices under the influence of a pressure, voltage or salinity
gradient. On a microscopic level the behaviour of the device is quantified by
the Onsager matrix , a generalised conductivity matrix relating the
local driving forces and the induced volume, charge and salt flux. Extending
from a local to a global linear-response relation is trivial for
homogeneous electrokinetic systems, but in this manuscript we derive a
generalised conductivity matrix from that applies also to
heterogeneous electrokinetic systems. This extension is especially important in
the case of an imposed salinity gradient, which gives necessarily rise to
heterogeneous devices. Within this formalism we can also incorporate a
heterogeneous surface charge due to, for instance, a charge regulating boundary
condition, which we show to have a significant impact on the resulting fluxes.
The predictions of the Poisson-Nernst-Planck-Stokes theory show good agreement
with exact solutions of the governing equations determined using the Finite
Element Method under a wide variety of parameters. Having established the
validity of the theory, it provides an accessible method to analyse
electrokinetic systems in general without the need of extensive numerical
methods. As an example, we analyse a Reverse Electrodialysis "blue energy"
system, and analyse how the many parameters that characterise such a system
affect the generated electrical power and efficiency
Dusty tails of evaporating exoplanets. II. Physical modelling of the KIC 12557548b light curve
Evaporating rocky exoplanets, such as KIC 12557548b, eject large amounts of
dust grains, which can trail the planet in a comet-like tail. When such objects
occult their host star, the resulting transit signal contains information about
the dust in the tail. We aim to use the detailed shape of the Kepler light
curve of KIC 12557548b to constrain the size and composition of the dust grains
that make up the tail, as well as the mass loss rate of the planet. Using a
self-consistent numerical model of the dust dynamics and sublimation, we
calculate the shape of the tail by following dust grains from their ejection
from the planet to their destruction due to sublimation. From this dust cloud
shape, we generate synthetic light curves (incorporating the effects of
extinction and angle-dependent scattering), which are then compared with the
phase-folded Kepler light curve. We explore the free-parameter space thoroughly
using a Markov chain Monte Carlo method. Our physics-based model is capable of
reproducing the observed light curve in detail. Good fits are found for initial
grain sizes between 0.2 and 5.6 micron and dust mass loss rates of 0.6 to 15.6
M_earth/Gyr (2-sigma ranges). We find that only certain combinations of
material parameters yield the correct tail length. These constraints are
consistent with dust made of corundum (Al2O3), but do not agree with a range of
carbonaceous, silicate, or iron compositions. Using a detailed, physically
motivated model, it is possible to constrain the composition of the dust in the
tails of evaporating rocky exoplanets. This provides a unique opportunity to
probe to interior composition of the smallest known exoplanets.Comment: 18 pages, 11 figures, A&A accepte
Patterns of Recurrence and Survival After Pelvic Treatment for Locally Advanced Penile Cancer
BACKGROUND: Penile cancer (PeCa) is rare, and the survival of patients with advanced disease remains poor. A better understanding of where treatment fails could aid the development of new treatment strategies. OBJECTIVE: To describe the disease course after pelvic lymph node (LN) treatment for PeCa. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analysed 228 patients who underwent pelvic LN treatment with curative intent from 1969 to 2016. The main treatment modalities were neoadjuvant chemotherapy, chemoradiation, and pelvic LN dissection. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: In the case of multiple recurrence locations, the most distant location was taken and recorded as follows: local (penis), regional (inguinal and pelvic LN), and distant (any other location). A competing risk analysis was used to calculate the time to recurrence per location, and a Kaplan-Meier analysis was used for overall survival (OS). RESULTS AND LIMITATIONS: The median follow-up of the surviving patients was 79 mo. The reason for pelvic treatment was pelvic involvement on imaging (29%), two or more tumour-positive inguinal LNs (61%), or inguinal extranodal extension (52%). More than half of the patients (61%) developed a recurrence. The median recurrence-free survival was 11 mo. The distribution was local in 9%, regional in 27%, and distant in 64% of patients. The infield control rate of nonsystemically treated patients was 61% (113/184). From the start of pelvic treatment, the median OS was 17 mo (95% confidence interval 12ā22). After regional or distant recurrence, all but one patient died of PeCa with median OS after a recurrence of 4.4 (regional) and 3.1 (distant) mo. This study is limited by its retrospective nature. CONCLUSIONS: The prognosis of PeCa patients treated on their pelvis who recur despite locoregional treatment is poor. The tendency for systemic spread emphasises the need for more effective systemic treatment strategies. PATIENT SUMMARY: In this report, we looked at the outcomes of penile cancer patients in an expert centre undergoing various treatments on their pelvis. We found that survival is poor after recurrence despite locoregional treatment. Therefore, better systemic treatments are necessary
Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography
Aims Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results The study population consisted of 1425 patients (869 men, 57 Ā± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). Conclusions The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CT
Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours : a multicentre retrospective observational cohort study
Publisher Copyright: Ā© 2022 The Author(s)Background: Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence regarding the safety of switching to S-1 after 5-FU- or capecitabine-associated cardiotoxicity is scarce. Patients and methods: This retrospective study (NCT04260269) was conducted at 13 centres in 6 countries. The primary endpoint was recurrence of cardiotoxicity after switch to S-1-based treatment due to 5-FU- or capecitabine-related cardiotoxicity: clinically meaningful if the upper boundary of the 95% confidence interval (CI; by competing risk) is not including 15%. Secondary endpoints included cardiac risk factors, diagnostic work-up, treatments, outcomes, and timelines of cardiotoxicity. Results: Per protocol, 200 patients, treated between 2011 and 2020 [median age 66 years (range 19-86); 118 (59%) males], were included. Treatment intent was curative in 145 (73%). Initial cardiotoxicity was due to capecitabine (n = 170), continuous infusion 5-FU (n = 22), or bolus 5-FU (n = 8), which was administered in combination with other chemotherapy, targeted agents, or radiotherapy in 133 patients. Previous cardiovascular comorbidities were present in 99 (50%) patients. Cardiotoxic events (n = 228/200) included chest pain (n = 125), coronary syndrome/infarction (n = 69), arrhythmia (n = 22), heart failure/cardiomyopathy (n = 7), cardiac arrest (n = 4), and malignant hypertension (n = 1). Cardiotoxicity was severe or life-threatening in 112 (56%) patients and led to permanent capecitabine/5-FU discontinuation in 192 (96%). After switch to S-1, recurrent cardiotoxicity was observed in eight (4%) patients (95% CI 2.02-7.89, primary endpoint met). Events were limited to grade 1-2 and occurred at a median of 16 days (interquartile range 7-67) from therapy switch. Baseline ischemic heart disease was a risk factor for recurrent cardiotoxicity (odds ratio 6.18, 95% CI 1.36-28.11). Conclusion: Switching to S-1-based therapy is safe and feasible after development of cardiotoxicity on 5-FU- or capecitabine-based therapy and allows patients to continue their pivotal fluoropyrimidine-based treatment.Peer reviewe
Novel clinical applications of state-of-the-art multi-slice computed tomography
Recent years have witnessed a rapid development of multi-slice computed tomography (MSCT) technology. The number of detector rows has increased from 4-slices to the current availability of 64-slice and even 320-slice systems. In addition, images are acquired with thinner slices and faster rotation times resulting in substantially improved image quality and diagnostic accuracy. Simultaneously, effective dose reduction acquisition techniques have been developed allowing considerable reduction of the radiation dose. Conceivably, these advancements may allow further expansion of the use of MSCT beyond the visual assessment of the presence or absence of significant coronary artery disease. Indeed, a particular advantage of the technique is that in addition to evaluation of the coronary arteries it also allows assessment of cardiac structures and function. The purpose of the current review is to discuss several novel applications of cardiac MSCT, including stenosis quantification, atherosclerotic plaque imaging and prognostification as well as imaging of left ventricular function, aortic and mitral valve anatomy using state-of-the-art technology
- ā¦