5 research outputs found
Vortices, Instantons and Branes
The purpose of this paper is to describe a relationship between the moduli
space of vortices and the moduli space of instantons. We study charge k
vortices in U(N) Yang-Mills-Higgs theories and show that the moduli space is
isomorphic to a special Lagrangian submanifold of the moduli space of k
instantons in non-commutative U(N) Yang-Mills theories. This submanifold is the
fixed point set of a U(1) action on the instanton moduli space which rotates
the instantons in a plane. To derive this relationship, we present a D-brane
construction in which the dynamics of vortices is described by the Higgs branch
of a U(k) gauge theory with 4 supercharges which is a truncation of the
familiar ADHM gauge theory. We further describe a moduli space construction for
semi-local vortices, lumps in the CP(N) and Grassmannian sigma-models, and
vortices on the non-commutative plane. We argue that this relationship between
vortices and instantons underlies many of the quantitative similarities shared
by quantum field theories in two and four dimensions.Comment: 32 Pages, 4 Figure
Optimizing linkage and retention to hypertension care in rural Kenya (LARK hypertension study): Study protocol for a randomized controlled trial
10.1186/1745-6215-15-143Trials15114
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Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria
Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (
n = 4) and an increase in absorbence (
n = 9) among vaccine recipients (
n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria