1 research outputs found
Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers
In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2
nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The
anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In
nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer
activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced
drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells
via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results
reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome
multidrug resistance of human breast cancer cells