The anisotropic quantum antiferromagnet on the Sierpinski gasket: Ground state and thermodynamics

We investigate an antiferromagnetic s=1/2 quantum spin system with anisotropic spin exchange on a fractal lattice, the Sierpinski gasket. We introduce a novel approximative numerical method, the configuration selective diagonalization (CSD) and apply this method to the Sierpinski gasket with N=42. Using this and other methods we calculate ground state energies, spin gap, spin-spin correlations and specific heat data and conclude that the s=1/2 quantum antiferromagnet on the Sierpinski gasket shows a disordered magnetic ground state with a very short correlation length of about 1 and an, albeit very small, spin gap. This conclusion holds for Heisenberg as well a for XY exchange.Comment: LaTeX: 16 pages, 9 figures, 1 tabl

Evaluierung optischer Methoden zur Messung rheologischer Eigenschaften von Gewebe

In dieser Arbeit wird sich mit den optischen Methoden zur Messung rheologischer Eigenschaften auseinandergesetzt. Es wird ein Aufbau konstruiert der die Methoden der Brillouin Mikroskopie und der Laser Speckle Rheologie kombiniert. Mit diesem werden verschiedene biologische Materialien untersucht

Pointing Enhancement for an Optical Laser Downlink Using Automated Image Processing

The small satellite Flying Laptop, launched in July 2017, was developed and built by graduate and undergraduate students at the Institute of Space Systems of the University of Stuttgart with support by space industry and research institutions. The mission goals are technology demonstration, earth observation, and serving as an educational satellite. At a mass of 110 kg, it features three-axis stabilized attitude control and several payloads, including an AIS receiver, a multi spectral camera system, a wide angle camera, and an optical communication terminal. The pointing requirement for the optical communication is an accuracy of less than 150 arcseconds during a target overflight. To fulfill this requirement, several measures are needed. A major part of them is the characterization of the attitude control system (ACS). Since there is no optical receiver onboard, it is not possible to perform closed loop tracking of the satellite attitude. Therefore, the absolute performance and the characteristic noise levels of the attitude control system, can only be determined with other payloads. In this case the multi-spectral camera system was used, providing a ground resolution of 25 m. To use the images from the satellite to improve the ACS, three steps have to be taken. As a first action, the images have to be georeferenced to know the position of each pixel in the WGS84 coordinate system. With this information, the deviation of the image center from the desired target is measured. This second step includes the calculation of the deviation matrix. To avoid a corruption of the attitude control of the satellite, the matrix is checked for unrealistic values in a third and final step. These three actions can be repeated as needed without human interaction. By updating the ACS model onboard the satellite, the results of the image processing are used to correct the off-pointing. This deviation is time invariant and is caused by an insufficient alignment of the satellite axes and the cameras on ground. In contrast to that, characterizing noise as a time variant factor, the ACS is tested over a long period of time. This is achieved by analyzing images from one, as well as from multiple target overflights. This conquers the issue of a very low image rate while observing high frequency attitude changes. Using this mechanism, the proposed process can be used to continuously monitor the pointing quality. As a first approach the described processing is done manually by comparing the target position on Earth with the center of the taken image. The method successfully showed an improvement of the pointing in the pictures, paving the way for their automation. This paper gives an overview of the needed image processing and tools to automatically use cameras on board the satellite to validate and improve the ACS periodically. First results of the long term characteristics and pointing improvements are shown

Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain

The isolation and structure elucidation of malettinins A–C (1–3) along with the new malettinin E (4) are described. The compounds were produced by the fungus Cladosporium sp. strain KF501, which was isolated from the German Wadden Sea. The malettinins are built up of tropolone/dihydropyran ring structures linked to a furan ring. The structure elucidation of the isolated compounds was achieved by means of one- and two-dimensional NMR spectroscopy supported by mass and UV data. The relative configuration of 4 was determined on the basis of single-crystal X-ray diffraction analysis. 1–4 exhibited antibacterial and antifungal activities when profiled against Xanthomonas campestris and Trichophyton rubrum. The influence of the chemical structure of the furan ring and of configurational changes on biological activities was observed

From Soyuz-docking manoeuvres to microalgae cultivation: hands-on training for Master's students

A strong connection between research and teaching at a university is crucial to offer students a unique opportunity to put in practice the concepts taught in theoretical lectures. At the University of Stuttgart, several hands-on training courses have been offered for eight years within the module “Selected hands-on training for space”. Those are adapted to the current research at the Institute of Space Systems. During one semester, students participate in two of the offered courses and are evaluated through an exam or a report. Three ECTS for the space specialization in the aerospace engineering Master are granted after successful completion. The limited places offered are usually filled up in matter of hours and the students’ feedback has been very positive every year. The module includes up to five different courses, depending on the semester. The Life Support Systems seminar is focused on the cultivation of microalgae, linked to the institute’s ISS Experiment photobioreactor PBR@LSR. After learning the basic life support system concepts, the students build and conduct their own microalgae photobioreactor experiment. In the Missions Analysis practical seminar, based on the work of several PhD candidates, the participants learn and put in practice aspects of mission planning with the help of the Astos Solutions software as well as the SPICE toolkit. During the Rendezvous and Docking practical training, students learn about the operation and handling of a spacecraft. Besides theoretical lectures, guided sessions in the simulator allow to put into practice the handling of common complex procedures, audio-visual perception and motor skills. This seminar is linked to the research carried out in the SIMSKILL experiment. In the Earth Remote Sensing seminar, students learn how to handle payload data for Earth observation and their scientific evaluation. The Flying Laptop, a satellite fully built at the institute and launched in 2017, is used for this course. Finally, the research carried out in the field of electrolysers and fuel cells for space applications at the institute prompted the establishment of a training course. After deepening their knowledge on both electrolysers and fuel cells, the students prepare, carry out and evaluate various experiments. This paper presents the different training courses from our institute and their link to the current research

Convergent evidence for validity of a performance-based ICT skills test

The goal of this study was to investigate sources of evidence of convergent validity supporting the construct interpretation of scores on a simulation-based ICT skills test. The construct definition understands ICT skills as reliant on ICT-specific knowledge as well as comprehension and problem-solving skills. On the basis of this, a validity argument comprising three claims was formulated and tested. (1) In line with the classical nomothetic span approach, all three predictor variables explained task success positively across all ICT skills items. As ICT tasks can vary in the extent to which they require construct-related knowledge and skills and in the way related items are designed and implemented, the effects of construct-related predictor variables were expected to vary across items. (2) A task-based analysis approach revealed that the item-level effects of the three predictor variables were in line with the targeted construct interpretation for most items. (3) Finally, item characteristics could significantly explain the random effect of problem-solving skills, but not comprehension skills. Taken together, the obtained results generally support the validity of the construct interpretation

Stability of Drugs Stored in Helicopters for Use by Emergency Medical Services: A Prospective Observational Study.

STUDY OBJECTIVE Drugs stored in rescue helicopters may be subject to extreme environmental conditions. The aim of this study was to measure whether drugs stored under the real-life conditions of a Swiss helicopter emergency medical service (HEMS) would retain their potency over the course of 1 year. METHODS A prospective, longitudinal study measuring the temperature exposure and concentration of drugs stored on 2 rescue helicopters in Switzerland over 1 year. The study drugs included epinephrine, norepinephrine, amiodarone, midazolam, fentanyl, naloxone, rocuronium, etomidate, and ketamine. Temperatures were measured inside the medication storage bags and the crew cabins at 10-minute intervals. Drug stability was measured on a monthly basis over the course of 12 months using high-performance liquid chromatography. The medications were considered stable at a minimum remaining drug concentration of 90% of the label claim. RESULTS Temperatures ranged from -1.2 °C to 38.1 °C (29.84 °F to 100.58 °F) inside the drug storage bags. Of all the temperature measurements inside the drug storage bags, 37% lay outside the recommended storage conditions. All drugs maintained a concentration above 90% of the label claim. The observation periods for rocuronium and etomidate were shortened to 7 months because of a supply shortage of reference samples. CONCLUSION Drugs stored under the real-life conditions of Swiss HEMS are subjected to temperatures outside the manufacturer's approved storage requirements. Despite this, all drugs stored under these conditions remained stable throughout our study. Real-life stability testing could be a way to extend drug exchange intervals

R91W mutation in Rpe65 leads to milder early-onset retinal dystrophy due to the generation of low levels of 11-cis-retinal

RPE65 is a retinal pigment epithelial protein essential for the regeneration of 11-cis-retinal, the chromophore of cone and rod visual pigments. Mutations in RPE65 lead to a spectrum of retinal dystrophies ranging from Leber's congenital amaurosis to autosomal recessive retinitis pigmentosa. One of the most frequent missense mutations is an amino acid substitution at position 91 (R91W). Affected patients have useful cone vision in the first decade of life, but progressively lose sight during adolescence. We generated R91W knock-in mice to understand the mechanism of retinal degeneration caused by this aberrant Rpe65 variant. We found that in contrast to Rpe65 null mice, low but substantial levels of both RPE65 and 11-cis-retinal were present. Whereas rod function was impaired already in young animals, cone function was less affected. Rhodopsin metabolism and photoreceptor morphology were disturbed, leading to a progressive loss of photoreceptor cells and retinal function. Thus, the consequences of the R91W mutation are clearly distinguishable from an Rpe65 null mutation as evidenced by the production of 11-cis-retinal and rhodopsin as well as by less severe morphological and functional disturbances at early age. Taken together, the pathology in R91W knock-in mice mimics many aspects of the corresponding human blinding disease. Therefore, this mouse mutant provides a valuable animal model to test therapeutic concepts for patients affected by RPE65 missense mutation