Manipulating self-focusing beams induced by high-dimensional parabolic umbilic beams

The excellent property that the intensity of autofocusing beams in the focal plane increases exponentially, makes them especially beneficial for biomedical treatment. We experimentally generate tunable (2+1)-dimensional circular parabolic umbilic beams (CPUBs) for the first time based on the high-dimensional diffraction catastrophe integral, which is determined by the potential function. Such CPUBs have circular and symmetrical intensity distributions in space through radial symmetry transformation. Due to the flexibility of high dimensionality, these light beams have rich light field structures and self-focusing property. Where, the maximum intensity suddenly increases by orders of magnitude in the focal plane. Unlike the classical circular Airy beams, CPUBs exhibit multiple self-focusing points along the optical axis and a needle-like structure during propagation, which can be affected by manipulating the control parameters. The rich properties provide a new perspective for exploring the novel physical mechanisms and phenomena in autofocusing beams. The experimental results verify the correctness of the numerical simulations. CPUBs greatly enrich the autofocusing beam family and will be advantageous for medical treatments, optical micromanipulation, and microscopic imaging

Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery

Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. During its development, nanotechnology has shown unprecedented potential for application to kidney diseases. However, nanotechnology has disadvantages such as high cost and poor bioavailability. In contrast, biopolymers are not only widely available but also highly bioavailable. Therefore, biopolymer-based nanosystems offer new promising solutions for the treatment of kidney diseases. This paper reviews the biopolymer-based nanosystems that have been used for renal diseases and describes strategies for the specific, targeted delivery of drugs to the kidney as well as the physicochemical properties of the nanoparticles that affect the targeting success

Anti-Osteoporotic Effect of Lactobacillus brevis AR281 in an Ovariectomized Mouse Model Mediated by Inhibition of Osteoclast Differentiation

Osteoporosis is a global disease characterized by weakened bone microarchitecture, leading to osteoporotic fractures. Estrogen replacement therapy is the traditional treatment for osteoporosis but carries with it an increased risk of cardiac events. In search of a safe and effective treatment, we used Lactobacillus brevis AR281, which has anti-inflammatory properties, to conduct a 7-week experiment, investigating its inhibitory effects on osteoporosis in an ovariectomized (ovx) mouse model. The results demonstrated that AR281 significantly improved bone microarchitecture and biomechanical strength in ovx mice by attenuating bone resorption. AR281 significantly decreased the critical osteoclast activator, the ratio of the receptor activator for nuclear factor kappa B (NF-κB) ligand (RANKL) to osteoprotegerin, and pro-inflammatory osteoclastogenic mediators, such as IL-1, IL-6, and IL-17, which can increase the RANKL expression. Moreover, AR281 modulated intestinal microbiota in ovx mice increased the abundance of Akkermansia, which is responsible for the improvement of gut epithelial barrier integrity. In an in vitro trial, AR281 suppressed the number of osteoclasts differentiated from the osteoclast precursor RAW264.7 cells caused by RANKL through the tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/NF-κB/nuclear factor of activated T cells c1 (NFATc1) pathway. Therefore, AR281 may be a natural alternative for combating osteoporosis