Modeling and Design of Passive Planar Components for EMI Filters

Les composants magnétiques en technologie planar répondent aux exigences actuelles de l Electronique de Puissance (EP), à savoir la montée en fréquence de commutation des structures d EP et la réduction du volume des convertisseurs. La première tendance impose des contraintes fortes en termes de compatibilité électromagnétique (CEM) des équipements. Ces dernières doivent être prises en compte par les ingénieurs dès la phase conception des convertisseurs en se basant sur des modèles fiables, peu développés pour les composants planar dans la littérature scientifique. Ce travail de thèse porte ainsi sur la modélisation des composants planar pour applications aux filtres CEM. Différentes méthodes sont développées au cours de cette thèse pour arriver à évaluer de manière fine les éléments parasites des inductances planar de mode commun : capacités parasites et inductances de fuite. Une partie du travail a porté sur la modélisation par circuits équivalents du comportement fréquentiel des inductances de MC. Une approche automatisée, basée sur un algorithme de fitting a ainsi été développée pour élaborer des circuits équivalents fiables et robustes. Des approches analytiques (Décomposition du Champ Electrique) et semi-analytiques (Fonctions de Green) ont aussi été proposées pour évaluer les valeurs des éléments parasites. La dernière partie de la thèse est plus orientée conception, avec la réalisation de deux structures de composants innovantes, la première se basant sur une technique de compensation des capacités parasites à l aide d éléments parasites structuraux et la seconde sur l association de deux noyaux magnétiques, possédant matériaux et géométries différentesThe magnetic components with planar technology join in the current trends in Power Electronics (PE), namely increasing the switching frequency of PE structures and reducing the size of the power converters. The first tendency imposes strong constraints in terms of electromagnetic compatibility of equipments. The latter has to be considered by engineers at the beginning of the design of Power converters on the basis of reliable models, which are not sufficiently developed for planar components in scientific literature. This PhD work thereby focuses on the modeling of planar components for the applications of EMI filters. Different methods are developed during this study in order to accurately evaluate the parasitic elements of planar common-mode chokes: parasitic capacitances and leakage inductances. A part of this dissertation concerns the equivalent circuit modeling of the frequency behavior of CM chokes. An automated approach, based on a fitting algorithm developed for elaborating reliable and robust equivalent circuits. Analytical approaches (Electric Field Decomposition) and semi-analytical (Green s Function) are proposed as well for calculating the values of these parasitic elements. The last part of this dissertation is oriented to conception, with the realization of two structures of innovative components, the first one based on a parasitic capacitance cancellation technique using structural parasitic elements and the second one on the association of two magnetic cores with different materials and geometriesVILLENEUVE D'ASCQ-ECLI (590092307) / SudocSudocFranceF

Early identification of recurrence in ovarian cancer: a comparison between the ovarian cancer metastasis index and CA-125 levels

Ovarian cancer (OC) is the second most common gynecologic malignancy. A clinical observational study was performed to investigate whether indicators that assess the risk of metastasis can identify recurrence earlier in OC patients. By successfully recruiting 41 patients with OC who underwent chemotherapy, we compared cancer antigen-125 (CA-125) and the ovarian cancer metastasis index (OCMI), which was previously developed by us in the clinic for this purpose. Our results showed that patients and their families generally took a sensible attitude toward disease progression and were willing to accept a new way to gain knowledge about the disease. Herein, the new way was the possibility of monitoring recurrence by introducing the OCMI into the clinic. Fifteen patients experienced recurrence during chemotherapy, implying treatment failure. For 53% of these patients, an abnormally high OCMI suggested a strong tendency toward metastasis at least one chemotherapy cycle prior to the pathological examination confirming recurrence. In comparison, the early recognition rate of recurrence using CA-125 levels was merely 13%. Furthermore, we found that the mean values of the OCMI no longer declined after the fourth chemotherapy cycle, implying that excessive chemotherapy brings no benefit to OC patients. In conclusion, our findings provide a novel and feasible approach to monitor the effectiveness of chemotherapy in the treatment of OC by assessing the potential risk of metastasis

Taxonomic and phylogenetic evaluation of Limnothrix strains (Oscillatoriales, Cyanobacteria) by adding Limnothrix planktonica strains isolated from central China

Six Limnothrix strains, isolated for the first time from a shallow eutrophic lake in central China, were taxonomically and phylogenetically evaluated by investigating their polyphasic characteristics, including morphological features, cellular ultrastructures, and 16S rRNA gene sequences. All the six strains were morphologically similar, and their trichomes were in average 1.7 mu m wide and cells 4.0 mu m long, and having small gas vesicles within cells, and therefore identified as Limnothrix planctonica (Woloszynska) Meffert. Cellular ultrastructures of them showed that peripheral thylakoids with 3-5 parallel layers were parietally distributed in the cells. The phylogenetic results based on the 16S rRNA gene sequences showed that all the Limnothrix strains, including the six in this study and those from the Genbank, formed two distinct clusters. The similarity in 16S rDNA sequences between these two clusters was lower than 90%, indicating that these Limnothrix strains belong to different genera. This is the first report on the morphology and phylogeny of L. planctonica strains, providing the new information on taxonomy of the genus Limnothrix.Six Limnothrix strains, isolated for the first time from a shallow eutrophic lake in central China, were taxonomically and phylogenetically evaluated by investigating their polyphasic characteristics, including morphological features, cellular ultrastructures, and 16S rRNA gene sequences. All the six strains were morphologically similar, and their trichomes were in average 1.7 mu m wide and cells 4.0 mu m long, and having small gas vesicles within cells, and therefore identified as Limnothrix planctonica (Woloszynska) Meffert. Cellular ultrastructures of them showed that peripheral thylakoids with 3-5 parallel layers were parietally distributed in the cells. The phylogenetic results based on the 16S rRNA gene sequences showed that all the Limnothrix strains, including the six in this study and those from the Genbank, formed two distinct clusters. The similarity in 16S rDNA sequences between these two clusters was lower than 90%, indicating that these Limnothrix strains belong to different genera. This is the first report on the morphology and phylogeny of L. planctonica strains, providing the new information on taxonomy of the genus Limnothrix

The Bone Marrow Edema Links to an Osteoclastic Environment and Precedes Synovitis During the Development of Collagen Induced Arthritis

Objectives: To determine the relationship between bone marrow edema (BME), synovitis, and bone erosion longitudinally using a collagen induced arthritis mice (CIA) model and to explore the potential pathogenic role of BME in bone erosion.Methods: CIA was induced in DBA/1J mice. BME and corresponding clinical symptoms of arthritis and synovitis during the different time points of CIA development were assayed by magnetic resonance imaging (MRI), arthritis sore, and histologic analyses. The expression of osteoclasts (OCs), OCs-related cytokines, and immune cells in bone marrow were determined by flow cytometry, immunohistochemistry, immunofluorescence staining, and real-time PCR. The OCs formation was estimated using in vitro assays.Results: MRI detected BME could emerge at day 25 in 70% mice after the first immunization (n = 10), when there were not any arthritic symptoms, histological or MRI synovitis. At day 28, BME occurred in 90% mice whereas the arthritic symptom and histological synovitis were only presented in 30 and 20% CIA mice at that time (n = 10). The emergence of BME was associated with an increased bone marrow OCs number and an altered distribution of OCs adherent to subchondral bone surface, which resulted in increased subchondral erosion and decreased trabecular bone number during the CIA process. Obvious marrow environment changes were identified after BME emergence, consisting of multiple OCs related signals, including highly expressed RANKL, increased proinflammatory cytokines and chemokines, and highly activated T cells and monocytes.Conclusions: BME reflects a unique marrow “osteoclastic environment,” preceding the arthritic symptoms and synovitis during the development of CIA

Classification of colon adenocarcinoma based on immunological characterizations: Implications for prognosis and immunotherapy

Accurate immune molecular typing is pivotal for screening out patients with colon adenocarcinoma (COAD) who may benefit from immunotherapy and whose tumor microenvironment (TME) was needed for reprogramming to beneficial immune-mediated responses. However, little is known about the immune characteristic of COAD. Here, by calculating the enrichment score of immune characteristics in three online COAD datasets (TCGA-COAD, GSE39582, and GSE17538), we identified 17 prognostic-related immune characteristics that overlapped in at least two datasets. We determined that COADs could be stratified into three immune subtypes (IS1–IS3), based on consensus clustering of these 17 immune characteristics. Each of the three ISs was associated with distinct clinicopathological characteristics, genetic aberrations, tumor-infiltrating immune cell composition, immunophenotyping (immune “hot” and immune “cold”), and cytokine profiles, as well as different clinical outcomes and immunotherapy/therapeutic response. Patients with the IS1 tumor had high immune infiltration but immunosuppressive phenotype, IS3 tumor is an immune “hot” phenotype, whereas those with the IS2 tumor had an immune “cold” phenotype. We further verified the distinct immune phenotype of IS1 and IS3 by an in-house COAD cohort. We propose that the immune subtyping can be utilized to identify COAD patients who will be affected by the tumor immune microenvironment. Furthermore, the ISs may provide a guide for personalized cancer immunotherapy and for tumor prognosis