Discussion of Intelligent Manufacturing of Complicated Electronic Equipment in the Informatization Age---Innovation and Challenges

In the background of global manufacturing industry moving towards digitization, networking and intelligence, based on the deep integration of new generation information communication technology and advanced manufacturing technology, the manufacturing characteristics of complex electronic equipment such as variety, changing batch, updating and replacing quickly, multi-disciplinary coupling and supply chain complex are analyzed. On this basis, the innovation characteristics of complex electronic equipment in the whole life cycle of product manufacturing such as technology application, R&D mode, production organization and management decision are studied. The main challenges in the rapid development of intelligent manufacturing of complex electronic equipment are further pointed out. In the future, with the continuous progress of information technology and advanced manufacturing technology, the current challenges of intelligent manufacturing of complex electronic equipment will be solved

The application effect of percutaneous cryoablation for the stage IIIB/IV advanced non-small-cell lung cancer after the failure of chemoradiotherapy

Summary: Background/Objective: A retrospective review is required to assess the application effect of percutaneous cryoablation on the stage IIIB/IV advanced non-small-cell lung cancer (NSCLC) after the failure of chemoradiotherapy. A total of twenty-two cases with stage IIIB/IV advanced NSCLC after failure of chemoradiotherapy were enrolled. Methods: Computed Tomography (CT) was used for the assessment of tumor response, and Functional Assessment of Cancer Therapy-General (FACT-G) was applied for the evaluation of quality of life. After the treatment of cryoablation, we performed a follow-up analysis. Results: The primary technique effectiveness of 100% was observed in the one month of follow-up. At three months, local tumor progression was shown in 4 of 31 lesions (13.6%). The one-year survival rate of 81.8% and progression-free rate of 27.8% were obtained. Six patients died 7, 9, 10, 12, 15 and 22 months after treatment, respectively. Decreased scores of total quality of life at one week after cryoablation (P = 0.006), but increased scores at one month after cryoablation (P = 0.024) were observed, compared with pre-cryoablation. Conclusion: Cryoablation contributes to the effective local tumor therapy for stage IIIB/IV advanced NSCLC after the failure of chemoradiotherapy. Keywords: Cryoablation, Lung cancer, Stage IIIB/I

Microwave Frequency Dissemination over a 212 km Cascaded Urban Fiber Link with Stability at the 10−18 Level

To synchronize standard frequency signals between long-distance laboratories, we carried out a frequency dissemination experiment over a 212 km cascaded urban fiber link. This cascaded link was composed of two 106 km fiber links, in which the fiber noise was compensated by two microwave frequency dissemination systems. The two adjacent frequency dissemination systems used different frequency transmitted signals, preventing the influence of signal crosstalk between the received signal of the previous stage and the transmitted signal of the second stage caused by microwave signal leakage. The frequency dissemination over the cascaded link showed a dissemination fractional frequency instability of 6.2 × 10−15 at 1 s and 6.4 × 10−18 at 40,000 s, which is better than the transfer stability over the same 212 km single-stage link

ABHD17C, a metabolic and immune-related gene signature, predicts prognosis and anti-PD1 therapy response in pancreatic cancer

Abstract Background PDAC is a highly malignant and immune-suppressive tumor, posing great challenges to therapy. Methods In this study, we utilized multi-center RNA sequencing and non-negative matrix factorization clustering (NMF) to identify a group of metabolism-related genes that could effectively predict the immune status and survival (both disease-free survival and overall survival) of pancreatic ductal adenocarcinoma (PDAC) patients. Subsequently, through the integration of single cell sequencing and our center's prospective and retrospective cohort studies, we identified ABHD17C, which possesses metabolic and immune-related characteristics, as a potential biomarker for predicting the prognosis and response to anti-PD1 therapy in PDAC. We then demonstrated how ABHD17C participates in the regulation of the immune microenvironment through in vitro glycolytic function experiments and in vivo animal experiments. Results Through screening for pancreatic cancer metabolic markers and immune status, we identified a critical molecule that inhibits pancreatic cancer survival and prognosis. Further flow cytometry analysis confirmed that ABHD17C is involved in the inhibition of the formation of the immune environment in PDAC. Our research found that ABHD17C participates in the metabolic process of tumor cells in in vitro and in vivo experiments, reshaping the immunosuppressive microenvironment by downregulating the pH value. Furthermore, through LDHA inhibition experiments, we demonstrated that ABHD17C significantly enhances glycolysis and inhibits the formation of the immune suppressive environment. In in vivo experiments, we also validated that ABHD17C overexpression significantly mediates resistance to anti-PD1 therapy and promotes the progression of pancreatic cancer. Conclusion Therefore, ABHD17C may be a novel and effective biomarker for predicting the metabolic status and immune condition of PDAC patients, and provide a potential predictive strategy for anti-PD1 therapy in PDAC

A Rasorber-Like Waveguide Based on Thin Film

A novel rasorber-like property is generated in the new designed waveguide, which is constructed by placing an etched lossy thin film in the rectangular waveguide. Two individual transmission modes are observed in this structure in the working range of the rectangular waveguide, which provide the absorption band and passband, respectively. A sample based on indium tin oxide film is also fabricated and measured, and the results show good agreements compared with those of the 3-D full-wave simulation. This letter may extend the application of thin films in the wave propagation area, especially in the electromagnetic shielding of practical electronics. Index Terms-Rasorber, thin film, waveguide

A Rasorber-Like Waveguide Based on Thin Film

A novel rasorber-like property is generated in the new designed waveguide, which is constructed by placing an etched lossy thin film in the rectangular waveguide. Two individual transmission modes are observed in this structure in the working range of the rectangular waveguide, which provide the absorption band and passband, respectively. A sample based on indium tin oxide film is also fabricated and measured, and the results show good agreements compared with those of the 3-D full-wave simulation. This letter may extend the application of thin films in the wave propagation area, especially in the electromagnetic shielding of practical electronics. Index Terms-Rasorber, thin film, waveguide