Complementary and Alternative Therapy with Traditional Chinese Medicine for Infertility

Infertility results in a country with a low birth rate and an aging population, and thus there is vested interest in treating this problem by using both complementary and alternative therapies, in addition to conventional western medicine. Traditional Chinese medicine (TCM) has been widely used for healthcare in the Eastern world for thousands of years. This chapter describes the evidence to support the role of TCM in the management of male and female infertility

Time-Delayed Magnetic Control and Narrowing of X-Ray frequency Spectra in Two-Target Nuclear Forward Scattering

Controlling and narrowing x-ray frequency spectra in magnetically perturbed two-target nuclear forward scattering is theoretically studied. We show that different hard-x-ray spectral redistributions can be achieved by single or multiple switching of magnetic field in nuclear targets. Our scheme can generate x-ray spectral lines with tenfold intensity enhancement and spectral width narrower than four times the nuclear natural linewidth. The present results pave the way towards a brighter and flexible x-ray source for precision spectroscopy of nuclear resonances using modern synchrotron radiation.Comment: 5 pages, 5 figure

Complementary Therapy with Traditional Chinese Medicine for Polycystic Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a common, heterogeneous, complex, endocrinopathic condition that causes menstrual dysfunction and infertility in women. Traditional Chinese medicine (TCM) has been widely used for PCOS in Far-East countries for thousands of years. There are significant advantages in treating PCOS with TCM. This chapter aims to investigate the current developments in TCM therapy for PCOS

Stationary Light Pulses in Cold Atomic Media

Stationary light pulses (SLPs), i.e., light pulses without motion, are formed via the retrieval of stored probe pulses with two counter-propagating coupling fields. We show that there exist non-negligible hybrid Raman excitations in media of cold atoms that prohibit the SLP formation. We experimentally demonstrate a method to suppress these Raman excitations and realize SLPs in laser-cooled atoms. Our work opens the way to SLP studies in cold as well as in stationary atoms and provides a new avenue to low-light-level nonlinear optics.Comment: 4 pages, 4 figure

Neuroprotective Effect of Paeonol Mediates Anti-Inflammation via Suppressing Toll-Like Receptor 2 and Toll-Like Receptor 4 Signaling Pathways in Cerebral Ischemia-Reperfusion Injured Rats

Paeonol is a phenolic compound derived from Paeonia suffruticosa Andrews (MC) and P. lactiflora Pall (PL). Paeonol can reduce cerebral infarction volume and improve neurological deficits through antioxidative and anti-inflammatory effects. However, the anti-inflammatory pathway of paeonol remains unclear. This study investigated the relationship between anti-inflammatory responses of paeonol and signaling pathways of TLR2 and TLR4 in cerebral infarct. We established the cerebral ischemia-reperfusion model in Sprague Dawley rats by occluding right middle cerebral artery for 60 min, followed by reperfusion for 24 h. The neurological deficit score was examined, and the brains of the rats were removed for cerebral infarction volume and immunohistochemistry (IHC) analysis. The infarction volume and neurological deficits were lower in the paeonol group (pretreatment with paeonol; 20 mg/kg i.p.) than in the control group (without paeonol treatment). The IHC analysis revealed that the number of TLR2-, TLR4-, Iba1-, NF-κB- (P50-), and IL-1β-immunoreactive cells and TUNEL-positive cells was significantly lower in the paeonol group; however, the number of TNF-α-immunoreactive cells did not differ between the paeonol and control groups. The paeonol reveals some neuroprotective effects in the model of ischemia, which could be due to the reduction of many proinflammatory receptors/mediators, although the mechanisms are not clear

Is intuition associated with ethical decision-making?

The relationship between intuition and ethical decision-making has been researched extensively during the past two decades. This study aimed at exploring empirically observable associations between intuition and the moral intensity of ethical decision-making processes. A scenario-based quantitative approach was used to collect data from 157 practising professional spirit mediums. It was found that only collective universal intuition had a significant positive association with the moral intensity of ethical decision-making processes. Personal experience intuition and collective archetype intuition were not significantly associated with moral intensity. This may explain why previous studies were unable to gauge the effects of intuition on ethical decision-making. The results suggest that a pure mind can improve one’s ability to make decisions. Thus, decision-makers would benefit by being more attuned to their sense of morality

The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein

AbstractBackground: Colicin E7 (ColE7) is one of the bacterial toxins classified as a DNase-type E-group colicin. The cytotoxic activity of a colicin in a colicin-producing cell can be counteracted by binding of the colicin to a highly specific immunity protein. This biological event is a good model system for the investigation of protein recognition.Results: The crystal structure of a one-to-one complex between the DNase domain of colicin E7 and its cognate immunity protein Im7 has been determined at 2.3 Å resolution. Im7 in the complex is a varied four-helix bundle that is identical to the structure previously determined for uncomplexed Im7. The structure of the DNase domain of ColE7 displays a novel α/β fold and contains a Zn2+ ion bound to three histidine residues and one water molecule in a distorted tetrahedron geometry. Im7 has a V-shaped structure, extending two arms to clamp the DNase domain of ColE7. One arm (α1∗–loop12–α2∗; where ∗ represents helices in Im7) is located in the region that displays the greatest sequence variation among members of the immunity proteins in the same subfamily. This arm mainly uses acidic sidechains to interact with the basic sidechains in the DNase domain of ColE7. The other arm (loop 23–α3∗–loop 34) is more conserved and it interacts not only with the sidechain but also with the mainchain atoms of the DNase domain of ColE7.Conclusions: The protein interfaces between the DNase domain of ColE7 and Im7 are charge-complementary and charge interactions contribute significantly to the tight and specific binding between the two proteins. The more variable arm in Im7 dominates the binding specificity of the immunity protein to its cognate colicin. Biological and structural data suggest that the DNase active site for ColE7 is probably near the metal-binding site