Bright 22 μ\mum Excess Candidates from WISE All-Sky Catalog and Hipparcos Main Catalog

In this paper we present a catalog which includes 141 bright candidates ($\leq10.27$ mag, V band) showing the infrared (IR) excess at 22 $\mu$m. Of which, 38 stars are known IR excess stars or disk, 23 stars are double or multiple stars and 4 are Be stars. While the remaining more than 70 stars are identified as the 22 $\mu$m excess candidates in our work. The criterion of selecting candidates is $K_s-[22]_{\mu m}$. All these candidates are selected from \emph{WISE} All-sky data cross-correlated with \emph{Hipparcos} Main Catalog and the likelihood-ratio technique is employed. Considering the effect of background, we introduce the \emph{IRAS} 100 $\mu$m level to exclude the high background. We also estimated the coincidence probability of these sources. In addition, we presented the optical to mid-infrared SEDs and optical images of all the candidates, and gave the observed optical spectra of 6 stars with NAOC's 2.16-m telescope. To measure for the dust amount around each star, the fractional luminosity is also provided. We also test whether our method of selecting IR excess stars can be used to search for extra-solar planets, we cross-matched our catalog with known IR-excess stars having planets but none is matched. Finally, we give the fraction of stars showing IR-excess for different spectral type of main-sequence stars.Comment: 45 pages, 16 figures, 4 tables. Accepted for publication in ApJ

Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats

Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression. The present study was conducted to explore the role of the cAMP cascade in antidepressant action of electroacupuncture (EA) treatment for chronic mild stress (CMS)-induced depression model rats. The results showed that EA improved significantly behavior symptoms in depression and dysfunction of AC-cAMP-PKA signal transduction pathway induced by CMS, which was as effective as fluoxetine. Moreover, the antidepressant effects of EA rather than Fluoxetine were completely abolished by H89, a specific PKA inhibitor. Consequently, EA has a significant antidepressant treatment in CMS-induced depression model rats, and AC-cAMP-PKA signal transduction pathway is crucial for it

Magnetic resonance morphologic features predict progression of incidental pancreatic cystic lesions during follow-up

PURPOSEWe aimed to evaluate which morphologic features on magnetic resonance imaging (MRI) could predict the progression of pancreatic cystic lesions (PCLs) that are suitable for follow-up.METHODSA total of 2176 MRI findings of PCLs were retrospectively reviewed between January 2009 and December 2016. The study population was composed of 223 patients. Clinical data and morphologic features of PCLs were recorded. We divided the individuals into two sub-groups according to the final features on MRI. Univariable and multivariable regression analyses were performed to identify independent risk factors for progression of PCLs.RESULTSA total of 84 PCLs (37.7%) progressed during follow-up, while 139 PCLs (62.3%) were stable. Age (odds ratio [OR], 1.042; P = 0.017), number of lesions (OR, 0.491; P = 0.048), communication to pancreatic duct (PD) (OR, 2.425; P = 0.007) and presence of septa (OR, 6.105; P < 0.001) were significant independent factors for progression of PCLs. Among 84 lesions that progressed, 23 lesions (27.4%) increased to ≥ 30 mm in diameter or showed worrisome imaging features at the end of follow-up that needed clinical intervention. The initial size and communication to PD were independent factors for progression of PCLs necessitating clinical intervention (P < 0.001 and P = 0.011, respectively).CONCLUSIONAge, number of the lesions, communication to PD and presence of septa were independent risk factors for the progression of PCLs, and the initial size and communication to PD could potentially predict PCLs needing clinical intervention

MR quantitative 3D shape analysis helps to distinguish mucinous cystic neoplasm from serous oligocystic adenoma

PURPOSEWe aimed to assess the performance of quantitative 3D shape analysis in the differential diagno- sis of pancreatic serous oligocystic adenoma (SOA) and mucinous cystic neoplasm (MCN).METHODSFour hundred thirty-two patients diagnosed with serous cystic neoplasms (SCNs) or MCNs were retrospectively reviewed from August 2014 to July 2019 and finally 87 patients with MCNs (n = 45) and SOAs (n = 42) were included. Clinical data and magnetic resonance morphologic fea- tures with 3D shape analysis of lesions (shape sphericity, compacity, and volume) were recorded and compared between MCNs and SOAs according to the pathology. Univariable and multivari- able regression analyses were used to identify independent impact factors for differentiating MCN from SOA.RESULTSThe age of MCN patients was younger than SOAs (43.02 ± 10.83 years vs. 52.78 ± 12.31 years; OR = 0.275; 95% CI: 0.098-0.768; P = .014). MCN has a higher female/male ratio than SOA (43/2 vs. 27/15; OR = 40.418; 95% CI: 2.704-604.171; P = .007) and was more often located in the distal of pancreas (OR = 31.403; 95% CI: 2.985-330.342; P = .004). Shape_Sphericity derived from 3D shape analysis was a significant independent factor in the multivariable analysis and the value of MCN was closer to 1 than SOA (OR = 35.153; 95% CI: 5.301-237.585; P < .001). Area under the receiver operating characteristic curve (AUC) of Shape_Sphericity was 0.923 (optimal cutoff value was 0.964876).CONCLUSIONShape_Sphericity in combination with age, sex, and location could help to distinguish MCN from SOA

Proposal for Measurement of the Two-body Neutron Decay using Microcalorimeter

The bound beta-decay (BoB) of neutron is also known as the two-body neutron decay, which is a rare decay mode into a hydrogen atom and an anti-neutrino. The state of neutrino can be exactly inferred by measuring the state of hydrogen atom, providing a possible pathway to explore new physics. However, this rare decay mode has not yet been observed so far since it was predicted in 1947. The challenge in observing this decay is not only that its cross section is extremely low, equivalent to about branching ratio of the order of $10^{-6}$ of the three-body decay, but also that the final-state hydrogen atom is neutral and has extremely low kinetic energy, which cannot be effectively detected. In this study, we propose a microcalorimeter-based scheme for measuring the kinetic energies of hydrogen atoms produced from BoB of ultracold neutrons, which has a great advantage in terms of accuracy of the energy measurement. In this study, first, several important issues that require rigorous considerations for the decay measurements and possible solutions are discussed. Then, the requirements of the neutron flux and the appropriate structure design of the microcalorimeter are present by theoretical calculations. In short, this paper outlines our proposed novel experimental scheme for observing the BoB mode, addressing the possible solutions to all the necessary problems

Detection and Analysis of Blood Dexmedetomidine in Drug-Facilitated Cases

Objective To establish a simple and rapid qualitative and quantitative detection method of dexmedetomidine in blood. Methods Blood was separated on the Allure PFP Propyl liquid chromatography column with isocratic elution after it was precipitated by acetonitrile and filtered. Qualitative and quantitative analysis of dexmedetomidine was performed using positive ion scan mode and multi-reaction monitoring mode. Results The limit of detection of dexmedetomidine in blood was 0.2 ng/mL and the limit of quantification was 0.5 ng/mL. The linearity of the method was good in the range of 0.5-1 000 ng/mL, and the correlation coefficient was greater than 0.99. The accuracy of the method was 90.34%-112.67% and the extraction recovery was 50.05%-91.08%, with no significant matrix effect. Conclusion This method is simple, selective and suitable for the qualitative and quantitative analysis of dexmedetomidine in blood, which can provide a reference for drug-facilitated cases involving dexmedetomidine

Two-fold symmetric superconductivity in the kagome superconductor RbV3Sb5

The recent discovered kagome superconductors provide a good platform for studying intertwined orders and novel states such as topology, superconductor, charge density wave, et al. The interplay of these orders may spontaneously break the rotational symmetry, and induce exotic phenomena such as nematicity, or even nematic superconductor. Here we report a two-fold rotational symmetric superconductivity of thin-film RbV3Sb5 in response to a direction-dependent in-plane magnetic fields, in contrast to the six-fold structural symmetry of the crystal lattice. The two-fold symmetry was evidenced by the magnetoresistance transport experiments, critical magnetic field measurements and the anisotropic superconducting gap. With different configuration, we further observed the six-fold symmetry superimposed on the two-fold symmetry near the boundary between normal states and superconducting states. Our results present the correlation-driven symmetry breaking and highlight the promising platform to study the intertwined orders such as unconventional superconductivity in this correlated kagome family

Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: A systematic review and meta-analysis of real-world evidences

BackgroundTo date, evidences with high evidence-level evaluating the association between liver diseases and hidradenitis suppurativa was lacking. Given that inconsistency exists in some of the previous observational studies, evaluating the prevalence of liver diseases in HS patients could potentially serve as a reference of future guidelines for HS comorbidity screening. The aim of the current study was to evaluate potential association between hidradenitis suppurativa and liver diseases and provide integrated evidences.MethodsA search in PubMed, Web of Science and Embase based on the syntaxes ‘‘hidradenitis suppurativa’’ or ‘‘acne inversa’’ with “comorbidities”, “liver diseases”, “fatty liver” or “hepatitis” was performed. Observational studies evaluating epidemiological association between hidradenitis suppurativa and the risk of all liver diseases, including specific diseases as non-alcoholic fatty liver disease, hepatitis B, hepatitis C were targeted to be extracted in this systematic review and meta-analysis.ResultsWithin the initial 702 records, there were finally 8 real-world observational studies extracted. Results suggest that patients with HS are associated with all liver diseases (OR= 1.50; 95% CI, 1.27, 1.76), non-alcoholic fatty liver disease (OR= 1.78; 95% CI, 1.28, 2.48) and hepatitis B (OR=1.48; 95% CI, 1.12, 1.94), but not hepatitis C (OR= 1.27; 95% CI, 0.78, 2.07). HS patients were associated with significantly increased risk of liver diseases, especially the risk of non-alcoholic fatty liver disease and hepatitis B.ConclusionsClinicians should be alert to the clinical relationship while caring people with hidradenitis suppurativa and the screening of liver function should be recommended to HS patients. Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022296034