Responding to the message: Responsive written feedback in a Maori to English transition context

This paper reports on the writing component of a community and school Maori to English literacy transition programme implemented in a kura kaupapa Maori (Maori language immersion school. 21 Year 6, 7 and 8 students received responsive written feedback for their writing in English, over a ten-week period, during their weekly independent writing time. Students’ stories were mailed to a young Maori woman (the third author) in a provincial city 100 kilometres from the kura . She was not known to any of the students prior to the study, but she acted as an interested audience, and responded in writing by focussing on the content or messages in students’ stories. She did not provide any corrective feedback on students’ writing. The study employed an intra-subject multiple-baseline research design across four school terms, with the responsive written feedback being introduced sequentially to each of three student Year groups. Measures were taken of total words written, adventurous words written, as well as holistic ratings of audience impact and language quality. Data demonstrate positive gains in both the quantity and quality of students’ writing, as well as maintenance of high levels of writing accuracy for all Year groups

Lattice Black Holes

We study the Hawking process on lattices falling into static black holes. The motivation is to understand how the outgoing modes and Hawking radiation can arise in a setting with a strict short distance cutoff in the free-fall frame. We employ two-dimensional free scalar field theory. For a falling lattice with a discrete time-translation symmetry we use analytical methods to establish that, for Killing frequency $\omega$ and surface gravity $\kappa$ satisfying $\kappa\ll\omega^{1/3}\ll 1$ in lattice units, the continuum Hawking spectrum is recovered. The low frequency outgoing modes arise from exotic ingoing modes with large proper wavevectors that "refract" off the horizon. In this model with time translation symmetry the proper lattice spacing goes to zero at spatial infinity. We also consider instead falling lattices whose proper lattice spacing is constant at infinity and therefore grows with time at any finite radius. This violation of time translation symmetry is visible only at wavelengths comparable to the lattice spacing, and it is responsible for transmuting ingoing high Killing frequency modes into low frequency outgoing modes.Comment: 26 pages, LaTeX, 2 figures included with psfig. Several improvements in the presentation. One figure added. Final version to appear in Phys.Rev.

Sparse Multi-Pitch and Panning Estimation of Stereophonic Signals

In this paper, we propose a novel multi-pitch estimator for stereophonic mixtures, allowing for pitch estimation on multi-channel audio even if the amplitude and delay panning parameters are unknown. The presented method does not require prior knowledge of the number of sources present in the mixture, nor on the number of harmonics in each source. The estimator is formulated using a sparse signal framework, and an efficient implementation using the ADMM is introduced. Numerical simulations indicate the preferable performance of the proposed method as compared to several commonly used multi-channel single pitch estimators, and a commonly used multi-pitch estimator

The Infrared Imaging Spectrograph (IRIS) for TMT: Instrument Overview

We present an overview of the design of IRIS, an infrared (0.84 - 2.4 micron) integral field spectrograph and imaging camera for the Thirty Meter Telescope (TMT). With extremely low wavefront error (<30 nm) and on-board wavefront sensors, IRIS will take advantage of the high angular resolution of the narrow field infrared adaptive optics system (NFIRAOS) to dissect the sky at the diffraction limit of the 30-meter aperture. With a primary spectral resolution of 4000 and spatial sampling starting at 4 milliarcseconds, the instrument will create an unparalleled ability to explore high redshift galaxies, the Galactic center, star forming regions and virtually any astrophysical object. This paper summarizes the entire design and basic capabilities. Among the design innovations is the combination of lenslet and slicer integral field units, new 4Kx4k detectors, extremely precise atmospheric dispersion correction, infrared wavefront sensors, and a very large vacuum cryogenic system.Comment: Proceedings of the SPIE, 9147-76 (2014

An overview of the NIRSPEC upgrade for the Keck II telescope

NIRSPEC is a 1-5 micron echelle spectrograph in use on the Keck II Telescope since 1999. The spectrograph is capable of both moderate (R~2,000) and high (R~25,000) resolution observations and has been a workhorse instrument across many astronomical fields, from planetary science to extragalactic observations. In the latter half of 2018, we will upgrade NIRSPEC to improve the sensitivity and stability of the instrument and increase its lifetime. The major components of the upgrade include replacing the spectrometer and slit-viewing camera detectors with Teledyne H2RG arrays and replacing all transputer-based electronics. We present detailed design, testing, and analysis of the upgraded instrument, including the finalized optomechanical design of the new 1-5 micron slit-viewing camera, final alignment and assembly of the science array, electronics systems, and updated software design.Comment: Proceedings of the 2018 SPIE Astronomical Telescopes & Instrumentatio

Design and development of MOSFIRE: the Multi-Object Spectrometer For Infra-Red Exploration at the Keck Observatory

MOSFIRE is a unique multi-object spectrometer and imager for the Cassegrain focus of the 10 m Keck 1 telescope. A refractive optical design provides near-IR (0.97 to 2.45 μm) multi-object spectroscopy over a 6.14' x 6.14' field of view with a resolving power of R~3,270 for a 0.7" slit width (2.9 pixels in the dispersion direction), or imaging over a field of view of 6.8' diameter with 0.18" per pixel sampling. A single diffraction grating can be set at two fixed angles, and order-sorting filters provide spectra that cover the K, H, J or Y bands by selecting 3rd, 4th, 5th or 6th order respectively. A folding flat following the field lens is equipped with piezo transducers to provide tip/tilt control for flexure compensation at the 0.1 pixel level. A special feature of MOSFIRE is that its multiplex advantage of up to 46 slits is achieved using a cryogenic Configurable Slit Unit or CSU developed in collaboration with the Swiss Centre for Electronics and Micro Technology (CSEM). The CSU is reconfigurable under remote control in less than 5 minutes without any thermal cycling of the instrument. Slits are formed by moving opposable bars from both sides of the focal plane. An individual slit has a length of 7.1" but bar positions can be aligned to make longer slits. When masking bars are removed to their full extent and the grating is changed to a mirror, MOSFIRE becomes a wide-field imager. Using a single, ASIC-driven, 2K x 2K H2-RG HgCdTe array from Teledyne Imaging Sensors with exceptionally low dark current and low noise, MOSFIRE will be extremely sensitive and ideal for a wide range of science applications. This paper describes the design and testing of the instrument prior to delivery later in 2010

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation

Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist. Of the 100 identified serotypes, ∼90% bind domain 1 of human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, making this an attractive target for development of therapies; however, ICAM-1 domain 1 is also required for host defence and regulation of cell trafficking, principally via its major ligand LFA-1. Using a mouse anti-human ICAM-1 antibody (14C11) that specifically binds domain 1 of human ICAM-1, we show that 14C11 administered topically or systemically prevented entry of two major groups of rhinoviruses, HRV16 and HRV14, and reduced cellular inflammation, pro-inflammatory cytokine induction and virus load in vivo. 14C11 also reduced cellular inflammation and Th2 cytokine/chemokine production in a model of major group HRV-induced asthma exacerbation. Interestingly, 14C11 did not prevent cell adhesion via human ICAM-1/LFA-1 interactions in vitro, suggesting the epitope targeted by 14C11 was specific for viral entry. Thus a human ICAM-1 domain-1-specific antibody can prevent major group HRV entry and induction of airway inflammation in vivo

Delayed marrow infusion in mice enhances hematopoietic and osteopoietic engraftment by facilitating transient expansion of the osteoblastic niche

Transplantation of bone marrow cells leads to engraftment of osteopoietic and hematopoietic progenitors. We sought to determine whether the recently described transient expansion of the host osteoblastic niche after marrow radioablation promotes engraftment of both osteopoietic and hematopoietic progenitor cells. Mice infused with marrow cells 24&nbsp;hours after total body irradiation (TBI) demonstrated significantly greater osteopoietic and hematopoietic progenitor chimerism than did mice infused at 30&nbsp;minutes or 6&nbsp;hours. Irradiated mice with a lead shield over 1 hind limb showed greater hematopoietic chimerism in the irradiated limb than in the shielded limb at both the 6- and 24-hour intervals. By contrast, the osteopoietic chimerism was essentially equal in the 2 limbs at each of these intervals, although it significantly increased when cells were infused 24&nbsp;hours compared with 6&nbsp;hours after TBI. Similarly, the number of donor phenotypic long-term hematopoietic stem cells was equivalent in the irradiated and shielded limbs after each irradiation-to-infusion interval but was significantly increased at the 24-hour interval. Our findings indicate that a 24-hour delay in marrow cell infusion after TBI facilitates expansion of the endosteal osteoblastic niche, leading to enhanced osteopoietic and hematopoietic engraftment.Transplantation of bone marrow cells leads to engraftment of osteopoietic and hematopoietic progenitors. We sought to determine whether the recently described transient expansion of the host osteoblastic niche after marrow radioablation promotes engraftment of both osteopoietic and hematopoietic progenitor cells. Mice infused with marrow cells 24hours after total body irradiation (TBI) demonstrated significantly greater osteopoietic and hematopoietic progenitor chimerism than did mice infused at 30minutes or 6hours. Irradiated mice with a lead shield over 1 hind limb showed greater hematopoietic chimerism in the irradiated limb than in the shielded limb at both the 6- and 24-hour intervals. By contrast, the osteopoietic chimerism was essentially equal in the 2 limbs at each of these intervals, although it significantly increased when cells were infused 24hours compared with 6hours after TBI. Similarly, the number of donor phenotypic long-term hematopoietic stem cells was equivalent in the irradiated and shielded limbs after each irradiation-to-infusion interval but was significantly increased at the 24-hour interval. Our findings indicate that a 24-hour delay in marrow cell infusion after TBI facilitates expansion of the endosteal osteoblastic niche, leading to enhanced osteopoietic and hematopoietic engraftment. © 2013

The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome

Although the pathogenic mechanisms that underlie autism are not well understood, there is evidence showing that metabotropic and ionotropic glutamate receptors are hyper-stimulated and the GABAergic system is hypo-stimulated in autism. Memantine is an uncompetitive antagonist of NMDA receptors and is widely prescribed for treatment of Alzheimer's disease treatment. Recently, it has been shown to improve language function, social behavior, and self-stimulatory behaviors of some autistic subjects. However the mechanism by which memantine exerts its effect remains to be elucidated. In this study, we used cultured cerebellar granule cells (CGCs) from Fmr1 knockout (KO) mice, a mouse model for fragile X syndrome (FXS) and syndromic autism, to examine the effects of memantine on dendritic spine development and synapse formation. Our results show that the maturation of dendritic spines is delayed in Fmr1-KO CGCs. We also detected reduced excitatory synapse formation in Fmr1-KO CGCs. Memantine treatment of Fmr1-KO CGCs promoted cell adhesion properties. Memantine also stimulated the development of mushroom-shaped mature dendritic spines and restored dendritic spine to normal levels in Fmr1-KO CGCs. Furthermore, we demonstrated that memantine treatment promoted synapse formation and restored the excitatory synapses to a normal range in Fmr1-KO CGCs. These findings suggest that memantine may exert its therapeutic capacity through a stimulatory effect on dendritic spine maturation and excitatory synapse formation, as well as promoting adhesion of CGCs